[article]
| Titre : |
3D modelling of Malassezia furfur skin interaction |
| Type de document : |
texte imprimé |
| Auteurs : |
Valérie Borrel, Auteur ; Antoine Florin, Auteur ; Maëlle Garion, Auteur ; Christel Boudry, Auteur ; Michel Salmon, Auteur |
| Année de publication : |
2022 |
| Article en page(s) : |
p. 51-53 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Dermatite sébhorrhéique
Dermatologie
Epiderme
Expression génique
Malassezia
Marqueurs biologiques
Modélisation tridimensionnelle
Relations hôte-champignon
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Straticell illustrates in a 3D model that Malassezia furfur invades the upper layers of the reconstructed epidermis with deleterious impacts on the barrier function, inducing an effective immune and inflammatory response, at both gene and protein levels.
Malassezia furfur is a lipid-dependent yeast naturally living on the skin. Despite its tolerance by the immune system under healthy condition, M. furfur overgrowth is associated with skin disorders such as dandruff.
Dandruff and its more severe form seborrheic dermatitis (SD), are common chronic inflammatory conditions characterized by an abnormal shedding of the skin in seborrheic areas of the body. While dandruff is restricted to the scalp, SD also affects oily rich areas of the face, causing itching, pruritic lesions and erythema.
Environmental and internal stress factors, dysregulation of the immune system and fungal colonization are amongst the main contributors to the development of SD and dandruff.1 It has been described that in dandruff, the quantity of Malassezia can increase up to 1.5 to 2 times its normal level.
This huge spread of yeast highly invades the epidermis, with detrimental consequences on the skin barrier function. Because the epidermis is the principal barrier against the penetration of chemicals and pathogens, any disruption increases microbial invasion and triggers both innate and acquired immune response.
Keratinocytes are playing a central role in this response by secreting key signaling molecules like antimicrobial peptides to overcome pathogenic infections, as well as various cytokines and interleukins to recruit inflammatory cells. In the case of Malassezia overgrowth, previous studies have reported the expression of some defensins and pro-inflammatory cytokines in response to infection. |
| Note de contenu : |
- Colonization of RHE with M. furfur and barrier disruption
- Impact on gene expression
- Secretion of protein biomarkers |
| En ligne : |
https://drive.google.com/file/d/1zmSouLpZxhh3o0d_hPimbYgbku4otzBA/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38707 |
in GLOBAL PERSONAL CARE > Vol. 23, N° 10 (11/2022) . - p. 51-53
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