| Titre : |
Barrier disruption, dehydration and inflammation : Investigation of the vicious circle underlying dry skin |
| Type de document : |
document électronique |
| Auteurs : |
Cécile Bize, Auteur ; Erwan Le Gelebart, Auteur ; Alain Moga, Auteur ; Bruno Payré, Auteur ; Christine Garcia, Auteur |
| Année de publication : |
2021 |
| Article en page(s) : |
p. 729-737 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Barrière cutanée
Dermo-cosmétologie
Extraits de plantes:Extraits (pharmacie)
Peau -- Inflammation
Peau -- Soins et hygiène
Sécheresse cutanéeUne xérose est un dessèchement de la peau.
Elle peut avoir différentes causes, comme certaines pathologies (dermatite atopique aussi appelé eczéma atopique), des carences, notamment en Vitamine A, ou des facteurs externes, comme les contacts avec des substances irritantes ou le traitement par certains médicaments.
Statistique
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : Many endogenous or exogenous factors, isolated or combined, can trigger dry skin disorder, leading to a water/lipids-depleted stratum corneum concomitant with uncomfortable rough and scaly skin surface. In a defensive reaction, the alteration of the skin barrier stimulates the production of cytokines to initiate homeostasis restoration but this can also induce an inflammatory response that further weakens the barrier. The two phenomena intertwining one another lead to the creation of a vicious circle, here called Inflamm'dryness, that maintains dry skin state. It is thus very important to investigate biological mechanisms involved in Inflamm'dryness to better manage dry skin.
- Methods : A 3D model mimicking dry skin has been developed. Adjustment of tape stripping level allowed to reproduce skin barrier alterations and resulting inflammation involved in dry skin. The effect of Helichrysum stoechas extract on this downward spiral was then investigated to validate the concept.
- Results : Tape-stripping permitted to successively remove the cell layers of the stratum corneum: the barrier function was altered and skin was inflamed creating a vicious circle, mimicking very dry skin prone to Inflamm'dryness. Helichrysum stoechas extract was not only able to resolve inflammation but also to reverse concurrently adverse tape-stripping effects and imparted significant structural and functional recovery of the barrier (e.g. on NMF and ceramides levels, TEWL, tissue organization).
- Conclusion : This 3D model reproduces Inflamm'dryness vicious circle present in dry skin and highlights the importance of breaking this process to improve dry skin conditions. Helichrysum stoechas extract is a promising active ingredient for the management of dry skin. |
| Note de contenu : |
- MATERIALS AND METHODS : Helichrysum stoechas extract - Statistical analysis
- RESULTS : Inflamm'dryness 3D model - Helichrysum stoechas extract breaks the vicious circle of Inflamm'dryness
- Table 1 : Evolution of skin barrier and inflammation markers |
| DOI : |
https://doi.org/10.1111/ics.12748 |
| En ligne : |
https://drive.google.com/file/d/1GSbf9XzqmBbg_WiO611oAsLfiSZBO-gV/view?usp=shari [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=37053 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° 6 (12/2021) . - p. 729-737
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