Enhanced piroctone olamine retention from shampoo for superior anti-dandruff efficacy / Eric S. Johnson in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 2 (03-04/2023)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 45, N° 2 (03-04/2023) . - p. 236-245 Titre : Enhanced piroctone olamine retention from shampoo for superior anti-dandruff efficacy Type de document : document électronique Auteurs : Eric S. Johnson, Auteur ; Debora W. Chang, Auteur ; James R. Schwartz, Auteur ; Ulrike Blume-Peytavi, Auteur ; James P. Henry, Auteur ; Tamara L. Caterino, Auteur ; Allison L. Talley, Auteur Année de publication : 2023 Article en page(s) : p. 236-245 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antifongiques Antipelliculaires Cheveux -- Soins et hygiène Cosmétiques Cuir chevelu Dermatite sébhorrhéique Desquamation Etudes cliniques Pellicules (dermatologie) Piroctone olamine Produits capillaires shampooings Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Background : Dandruff is a pervasive chronic condition which negatively impacts quality of life. Effective treatment requires efficient delivery of scalp benefit agents that control commensal scalp Malassezia levels. Delivery of benefit agents from shampoos requires balancing many technical parameters to achieve the desired outcome without sacrificing secondary parameters, such as cosmetic attributes. - Objectives : To develop formulation technologies that increase the shampoo delivery efficiency of the scalp benefit agent piroctone olamine (PO). Increased delivery should result in increased anti-dandruff efficacy. - Methods : Micellar Stability and Association parameters were quantified via dynamic surface tension and nuclear magnetic resonance (NMR) diffusion parameters, respectively. PO delivery has been assessed in vivo both on the scalp surface and follicular infindibula using extraction procedures and analytical analysis. Clinical anti-dandruff efficacy was assessed for an advanced delivery technology prototype in comparison to standard delivery technology. - Results : Shampoo prototypes have been developed that increase the delivery efficiency of PO. Both surfactant and polymer coacervate-based approaches have been developed. Decreased micellar stability results in weaker association between PO and micelles, resulting in more efficient PO retention on the scalp surface and delivery to the infundibula. Increased charge density of cationic polymers optimizes coacervation enabling improved PO delivery as well. Increased PO delivery has been shown clinically to result in higher anti-dandruff efficacy as measured by both visible flakes and underlying biomarkers. - Conclusion : Increased efficiency PO delivery shampoos have been developed by optimization of both surfactant and coacervate parameters. The increased deposition efficiency results in significantly more products with significantly greater anti-dandruff efficacy. Note de contenu : - MATERIALS AND METHODS : Shampoo products and compositions evaluated - Measurement of Micellar Stability parameter (θ) - Measurement of Micellar Association parameter (Ds/Da) - Measurement of scalp surface retention of piroctone olamine in vivo - Measurement of infundibular delivery of piroctone olamine in vivo - Clinical efficacy study design - Assessment of flaking severity - Assessment of histamine and ratio of IL1ra/IL-1α from scalp surface - Test products - Statistical analysis - RESULTS : Micellar Stability parameter evaluations - Micellar Association parameter (Ds/Da) - Scalp surface retention of piroctone olamine in vivo - Infundibular delivery of piroctone olamine in vivo - Evaluation of Anti-Dandruff clinical efficacy - Table 1 : Summary of shampoo compositions evaluated - Table 2 : Summary of Micellar Stability parameter and Micellar Association parameter data - Table 3 : Summary of Micellar Association data and PO retention - Table 4 : Summary of piroctone olamine scalp retention data - Table 5 : Summary of anti-dandruff clinical evaluation DOI : https://doi.org/10.1111/ics.12835 En ligne : https://drive.google.com/file/d/15x6UeCPskFUzXhclO36lFCI1b11GE8SC/view?usp=share [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=39173 [article]

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Scalp application of antioxidants improves scalp condition and reduces hair shedding in a 24-week randomized, double-blind, placebo-controlled clinical trial / Michael G. Davis in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° S1 (11/2021)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° S1 (11/2021) . - p. 14-25 Titre : Scalp application of antioxidants improves scalp condition and reduces hair shedding in a 24-week randomized, double-blind, placebo-controlled clinical trial Type de document : document électronique Auteurs : Michael G. Davis, Auteur ; Melissa P. Piliang, Auteur ; Wilma F. Bergfeld, Auteur ; Tamara L. Caterino, Auteur ; Brian K. Fisher, Auteur ; Jarek P. Sacha, Auteur ; Gregory J. Carr, Auteur ; Laura T. Moulton, Auteur ; Deborah J. Whittenbarger, Auteur ; James R. Schwartz, Auteur Année de publication : 2021 Article en page(s) : p. 14-25 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Alopécie Antioxydants Cheveux -- Croissance Cheveux -- Soins et hygiène Cosmétiques Cuir chevelu -- Soins et hygiène Dermo-cosmétologie Formulation (Génie chimique) Produits capillaires Statistique Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Increasing hair fullness is a global unmet need for many men and women. An approach to the problem is to decrease hair fall or shedding by reducing scalp stratum corneum oxidation and barrier damage to increase hair retention. This study evaluated a combination of functional antioxidants and barrier-enhancing cosmetic ingredients to improve scalp condition thereby enabling stronger hair anchorage and longer retention. - Methods : Male and female subjects with normal scalp condition and self-perceived hair thinning participated in a 24-week, double-blind, placebo-controlled, randomized clinical study assessing either a regimen of treatment shampoo and leave-on treatment containing functional antioxidant and barrier-enhancing agents or an identical placebo chassis shampoo control. The functional ingredients were piroctone olamine, zinc pyrithione, zinc carbonate, niacinamide, panthenol and caffeine. At baseline and after 8, 16 and 24 weeks of product use, several measurements were taken: hair shedding, total hair count (by phototrichogram), hair samples, TEWL and evaluation of biomarkers of scalp and hair conditions. Subjects also completed self-assessment questionnaires. - Results : Statistically significant effects for functional ingredient-containing treatment regimen versus a placebo control shampoo formulation were observed for reduced hair shedding, increased total hair count, reduced TEWL and improvement in scalp biomarker values. Subjects also noticed these improvements assessed via self-assessment questionnaires. - Conclusions : These results establish that the use of functional antioxidant and barrier-enhancing agents to further improve scalp condition can enable a reduction in hair shedding and thus an increase in perceived hair fullness. The underlying improvements in scalp condition suggest the hair benefits were achieved as a result of improved scalp skin barrier and scalp condition leading to a viable preventative approach for hair thinning. Note de contenu : - MATERIALS AND METHODS : Hair products - Study design and subjects - RESULTS : Canfield total hair count - Hair shedding - Hair diameter - Subject self-assessments - Table 1 : Compositions of Treatment formulations - Table 2 : Hair and scalp measurement schedule per clinical site visit Statistics Table 3 : Subject hair and scalp self-assessment questionnaire responses DOI : https://doi.org/10.1111/ics.12734 En ligne : https://drive.google.com/file/d/1on_BgkcGCHsdoJ6P-2aQ4TsxsE731KNh/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=36876 [article]

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Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8-week randomized, double-blind, placebo-controlled clinical study / Michael G. Davis in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° S1 (11/2021)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° S1 (11/2021) . - p. 26-33 Titre : Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8-week randomized, double-blind, placebo-controlled clinical study Type de document : document électronique Auteurs : Michael G. Davis, Auteur ; Melissa P. Piliang, Auteur ; Wilma F. Bergfeld, Auteur ; Tamara L. Caterino, Auteur ; Brian K. Fisher, Auteur ; Jarek P. Sacha, Auteur ; Greg J. Griffin, Auteur ; Laura T. Moulton, Auteur ; Deborah J. Whittenbarger, Auteur ; Supriya Punyani, Auteur ; James R. Schwartz, Auteur Année de publication : 2021 Article en page(s) : p. 26-33 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Alopécie Antioxydants Barrière cutanée Cheveux -- Croissance Cheveux -- Soins et hygiène Cosmétiques Cuir chevelu -- Soins et hygiène Dermo-cosmétologie Evaluation Formulation (Génie chimique) shampooings Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Increasing scalp hair fullness is a global unmet consumer need. An approach to decrease hair shedding by reducing scalp stratum corneum oxidation via a combination of antioxidant and barrier-enhancing technologies has been previously demonstrated. The purpose of this study was to test the effectiveness of the individual antioxidant piroctone olamine in two different product forms (shampoo or leave-on product) for activity to improve hair retention. - Methods : Female subjects with self-perceived hair thinning participated in an 8-week, double-blind, placebo-controlled, randomized clinical study to evaluate either a piroctone olamine (PO) containing shampoo or a PO containing leave on treatment, each relative to their corresponding placebo formulation Too many periods. Results for phototrichograms, TEWL, and biomarker analysis of scalp condition for the shampoo treatments are discussed. Phototrichogram results are shared for the assessment of the leave on treatment. - Results : Statistically significant increases in hair amount were observed by phototrichogram after use of both PO-containing products versus placebo formulations. The PO shampoo treatment also significantly decreased oxidative stress on the hair and scalp, and improved scalp condition as assessed by TEWL and scalp biomarker values. - Conclusion : These results illustrate the effectiveness of a cosmetic antioxidant to improve scalp condition thereby improving hair retention. The observed improvements in scalp condition are consistent with previous reports with other antioxidant technologies and suggest that the hair retention effect was achieved by preventing oxidative damage to the scalp. Note de contenu : - MATERIALS AND METHODS : Study design and subjects - Study design and sample size for assessment of the shampoo treatments - Study design and sample size for assessment of the leave-on treatments - Study procedures - Statistics - RESULTS : Total hair counts Table 1 : Compositions of treatment formulations DOI : https://doi.org/10.1111/ics.12737 En ligne : https://drive.google.com/file/d/1fO1cZSHgD02ug0rwQfzam1vGWqCNfkae/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=36877 [article]

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