Scalp application of antioxidants improves scalp condition and reduces hair shedding in a 24-week randomized, double-blind, placebo-controlled clinical trial / Michael G. Davis in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° S1 (11/2021)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° S1 (11/2021) . - p. 14-25 Titre : Scalp application of antioxidants improves scalp condition and reduces hair shedding in a 24-week randomized, double-blind, placebo-controlled clinical trial Type de document : document électronique Auteurs : Michael G. Davis, Auteur ; Melissa P. Piliang, Auteur ; Wilma F. Bergfeld, Auteur ; Tamara L. Caterino, Auteur ; Brian K. Fisher, Auteur ; Jarek P. Sacha, Auteur ; Gregory J. Carr, Auteur ; Laura T. Moulton, Auteur ; Deborah J. Whittenbarger, Auteur ; James R. Schwartz, Auteur Année de publication : 2021 Article en page(s) : p. 14-25 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Alopécie Antioxydants Cheveux -- Croissance Cheveux -- Soins et hygiène Cosmétiques Cuir chevelu -- Soins et hygiène Dermo-cosmétologie Formulation (Génie chimique) Produits capillaires Statistique Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Increasing hair fullness is a global unmet need for many men and women. An approach to the problem is to decrease hair fall or shedding by reducing scalp stratum corneum oxidation and barrier damage to increase hair retention. This study evaluated a combination of functional antioxidants and barrier-enhancing cosmetic ingredients to improve scalp condition thereby enabling stronger hair anchorage and longer retention. - Methods : Male and female subjects with normal scalp condition and self-perceived hair thinning participated in a 24-week, double-blind, placebo-controlled, randomized clinical study assessing either a regimen of treatment shampoo and leave-on treatment containing functional antioxidant and barrier-enhancing agents or an identical placebo chassis shampoo control. The functional ingredients were piroctone olamine, zinc pyrithione, zinc carbonate, niacinamide, panthenol and caffeine. At baseline and after 8, 16 and 24 weeks of product use, several measurements were taken: hair shedding, total hair count (by phototrichogram), hair samples, TEWL and evaluation of biomarkers of scalp and hair conditions. Subjects also completed self-assessment questionnaires. - Results : Statistically significant effects for functional ingredient-containing treatment regimen versus a placebo control shampoo formulation were observed for reduced hair shedding, increased total hair count, reduced TEWL and improvement in scalp biomarker values. Subjects also noticed these improvements assessed via self-assessment questionnaires. - Conclusions : These results establish that the use of functional antioxidant and barrier-enhancing agents to further improve scalp condition can enable a reduction in hair shedding and thus an increase in perceived hair fullness. The underlying improvements in scalp condition suggest the hair benefits were achieved as a result of improved scalp skin barrier and scalp condition leading to a viable preventative approach for hair thinning. Note de contenu : - MATERIALS AND METHODS : Hair products - Study design and subjects - RESULTS : Canfield total hair count - Hair shedding - Hair diameter - Subject self-assessments - Table 1 : Compositions of Treatment formulations - Table 2 : Hair and scalp measurement schedule per clinical site visit Statistics Table 3 : Subject hair and scalp self-assessment questionnaire responses DOI : https://doi.org/10.1111/ics.12734 En ligne : https://drive.google.com/file/d/1on_BgkcGCHsdoJ6P-2aQ4TsxsE731KNh/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=36876 [article]

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Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8-week randomized, double-blind, placebo-controlled clinical study / Michael G. Davis in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° S1 (11/2021)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° S1 (11/2021) . - p. 26-33 Titre : Scalp application of the antioxidant piroctone olamine reduces hair shedding in an 8-week randomized, double-blind, placebo-controlled clinical study Type de document : document électronique Auteurs : Michael G. Davis, Auteur ; Melissa P. Piliang, Auteur ; Wilma F. Bergfeld, Auteur ; Tamara L. Caterino, Auteur ; Brian K. Fisher, Auteur ; Jarek P. Sacha, Auteur ; Greg J. Griffin, Auteur ; Laura T. Moulton, Auteur ; Deborah J. Whittenbarger, Auteur ; Supriya Punyani, Auteur ; James R. Schwartz, Auteur Année de publication : 2021 Article en page(s) : p. 26-33 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Alopécie Antioxydants Barrière cutanée Cheveux -- Croissance Cheveux -- Soins et hygiène Cosmétiques Cuir chevelu -- Soins et hygiène Dermo-cosmétologie Evaluation Formulation (Génie chimique) shampooings Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Increasing scalp hair fullness is a global unmet consumer need. An approach to decrease hair shedding by reducing scalp stratum corneum oxidation via a combination of antioxidant and barrier-enhancing technologies has been previously demonstrated. The purpose of this study was to test the effectiveness of the individual antioxidant piroctone olamine in two different product forms (shampoo or leave-on product) for activity to improve hair retention. - Methods : Female subjects with self-perceived hair thinning participated in an 8-week, double-blind, placebo-controlled, randomized clinical study to evaluate either a piroctone olamine (PO) containing shampoo or a PO containing leave on treatment, each relative to their corresponding placebo formulation Too many periods. Results for phototrichograms, TEWL, and biomarker analysis of scalp condition for the shampoo treatments are discussed. Phototrichogram results are shared for the assessment of the leave on treatment. - Results : Statistically significant increases in hair amount were observed by phototrichogram after use of both PO-containing products versus placebo formulations. The PO shampoo treatment also significantly decreased oxidative stress on the hair and scalp, and improved scalp condition as assessed by TEWL and scalp biomarker values. - Conclusion : These results illustrate the effectiveness of a cosmetic antioxidant to improve scalp condition thereby improving hair retention. The observed improvements in scalp condition are consistent with previous reports with other antioxidant technologies and suggest that the hair retention effect was achieved by preventing oxidative damage to the scalp. Note de contenu : - MATERIALS AND METHODS : Study design and subjects - Study design and sample size for assessment of the shampoo treatments - Study design and sample size for assessment of the leave-on treatments - Study procedures - Statistics - RESULTS : Total hair counts Table 1 : Compositions of treatment formulations DOI : https://doi.org/10.1111/ics.12737 En ligne : https://drive.google.com/file/d/1fO1cZSHgD02ug0rwQfzam1vGWqCNfkae/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=36877 [article]

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