Water-in-oil microemulsions composed of monoolein enhanced the transdermal delivery of nicotinamide / Momoko Kitaoka in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° 3 (06/2021)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° 3 (06/2021) . - p. 302-310 Titre : Water-in-oil microemulsions composed of monoolein enhanced the transdermal delivery of nicotinamide Type de document : document électronique Auteurs : Momoko Kitaoka, Auteur ; Trung Cong Nguyen, Auteur ; Masahiro Goto, Auteur Année de publication : 2021 Article en page(s) : p. 302-310 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Absorption cutanée Barrière cutanée Caractérisation Dermo-cosmétologie Formulation (Génie chimique) Microémulsions Nicotinamide Peau -- Anatomie Peau -- Physiologie Peau -- Soins et hygiène Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Nicotinamide, also known as niacinamide, is a water-soluble vitamin that is used to prevent and treat acne and pellagra. It is often found in water-based skin care cosmetics because of its high water solubility. Nicotinamide is a small molecule with a molar mass of 122.1 g/mol. However, it has a hydrophilic nature that becomes an obstacle when it penetrates through the skin. The topmost layer of the skin, the stratum corneum, acts as a strong hydrophobic barrier for such hydrophilic molecules. The oil-based formulations are expected to enhance the transdermal delivery efficiency of nicotinamide. - Methods : We have developed oil-based microemulsion formulations composed of a squalane vehicle. Monoolein was used as an emulsifier that has a potential to enhance the nicotinamide delivery through the stratum corneum. - Results : Because the mean size of the emulsions measured by dynamic light scattering was 20.9 ± 0.4 nm, the microemulsion formulation was stable under the long-term storage. Monoolein acted as a skin penetration enhancer, and it effectively enabled the penetration of nicotinamide through human abdominal skin, compared with nicotinamide in a phosphate-buffered saline solution. The flux was increased 25-fold. Microscopic imaging revealed that the hydrophilic bioactive compounds penetrated through the intercellular spaces in the epidermis. - Conclusion : The monoolein-based microemulsion was transparent and stable, suggesting that it is a promising formulation for a transdermal nicotinamide delivery. Note de contenu : - MATERIALS AND METHODS : Materials - Preparation of microemulsions carrying nicotinamide - Particle size analysis - Reversed-phase high-performance liquid chromatography (HPLC) - Nicotinamide release test from the microemulsion formulation - In vitro skin penetration experiment - Fluorescence confocal laser scanning microscopy - RESULTS AND DISCUSSION : Preparation and characteristics of microemulsions - In vitro penetration of nicotinamide - Histology analysis - Table 1 : Compositions of 1 mL of the water-in-oil microemulsion formulations containing nicotinamide (5 mg/mL) - Table 2 : Particle z-average and polydispersity index (PDI) of the microemulsions as measured through dynamic light scattering - Table 3 : Skin penetration parameters of nicotinamide from a microemulsion formulation and PBS DOI : https://doi.org/10.1111/ics.12695 En ligne : https://drive.google.com/file/d/1S_tMLxYvVTqhDv2nBvZ_b9VETyVgpjaL/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35897 [article]

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