| Titre : |
Effective reduction of post-inflammatory hyperpigmentation with the tyrosinase inhibitor isobutylamido-thiazolyl-resorcinol (Thiamidol) |
| Type de document : |
document électronique |
| Auteurs : |
Dennis Roggenkamp, Auteur ; Ncoza Dlova, Auteur ; Tobias Mann, Auteur ; Jan Batzer, Auteur ; Julia Riedel, Auteur ; Martina Kausch, Auteur ; Ivica Zoric, Auteur ; Ludger Kolbe, Auteur |
| Année de publication : |
2021 |
| Article en page(s) : |
p. 292-301 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Anti tyrosinase
Dermo-cosmétologie
Emulsions -- Emploi en cosmétologie
Etude in vivo
Formulation (Génie chimique)
Peau -- Physiologie
Pigmentation, Troubles de la
Statistique
Thiamidol
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : Post-inflammatory hyperpigmentation (PIH) is a major cosmetic concern especially in individuals with darker skin complexion. Unfortunately, treatment with anti-inflammatory ingredients alone does not prevent the development of hyperpigmented spots. Recently, isobutylamido-thiazolyl-resorcinol (Thiamidol) was described as a very potent inhibitor of human tyrosinase. The objective of this research was to investigate the potential of this compound to prevent PIH induced by epidermal wounding (suction blister) and related to acne.
- Methods : Suction blister-induced PIH was treated with a formulation containing Thiamidol or a vehicle for 3 months, and the changes in hyperpigmentation were monitored by spectroscopic measurements. The effect of skin care formulations containing Thiamidol on acne-related PIH was investigated in two studies, a vehicle-controlled, double-blinded, randomized clinical study and a clinical observational study. Both studies had a duration of 3 months and included assessments such as clinical photography, clinical grading and melanin index measurements.
- Results : Already after 2 weeks of treatment, suction blister sites treated with Thiamidol were significantly lighter than control sites and improved throughout the treatment period. Subjects´ self-grading demonstrated that Thiamidol significantly improved the visibility of acne-induced hyperpigmentation compared to the vehicle treatment. A skin care regimen with Thiamidol significantly improved acne-related PIH over 12 weeks shown by Mexameter measurements, expert grading, self-grading and clinical photography.
- Conclusion : Thiamidol represents a safe and effective ingredient for cosmetic products against post-inflammatory hyperpigmentation. |
| Note de contenu : |
- Test formulations
- In vivo studies with Thiamidol-containing formulations
- Statistical analysis |
| DOI : |
https://doi.org/10.1111/ics.12694 |
| En ligne : |
https://drive.google.com/file/d/1SX8mlLSVCm9kO_TNeqRk_MswkWU_LC-t/view?usp=shari [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35896 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° 3 (06/2021) . - p. 292-301
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