| Titre : |
Effect of hydroxypropyl-B-cyclodextrin in fluid and semi-solid submicron emulsions on physiological skin parameters during regular in vivo application |
| Type de document : |
document électronique |
| Auteurs : |
Astrid Pany, Auteur ; Marie Wohlgenannt, Auteur ; Safoura Klopprogge, Auteur ; Michael Wolzt, Auteur ; Thomas Heuser, Auteur ; Harald Kotisch, Auteur ; Claudia Valenta, Auteur ; Victoria Klang, Auteur |
| Année de publication : |
2021 |
| Article en page(s) : |
p. 263-268 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Barrière cutanée
Caractérisation
Colloides
Cosmétiques
Emulsions -- Emploi en cosmétologie
Formulation (Génie chimique)
Peau -- Soins et hygiène
Rhéologie
Statistique
Tests de sécurité
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : The aim of the present study was to evaluate the effect of hydroxypropyl-β-cyclodextrin (HP-β-CD) in cosmetic submicron emulsions and submicron emulsion gels on physiological skin parameters during regular application in a clinical set-up.
- Methods : Formulation morphology was investigated using cryo-transmission electron microscopy. Stability of the employed formulations was determined by photon correlation spectroscopy, measurement of pH and rheological properties. Effect on physiological skin parameters was evaluated during regular application over four weeks in a parallel group study (n = 15, healthy forearm skin) with a Corneometer, Sebumeter, skin-pH-Meter, Aquaflux and an Epsilon sensor. Confocal Raman spectroscopy was employed to monitor urea and NMF levels.
- Results : Both submicron emulsions and gels showed satisfying storage stability irrespective of cyclodextrin incorporation. No statistically significant effects on skin barrier function and any of the observed parameters were obtained, indicating good skin tolerability of all tested formulations.
- Conclusion : Results suggest good skin tolerability of the developed cosmetic submicron emulsions and gels with HP-β-CD. |
| Note de contenu : |
- MATERIALS AND METHODS : Materials - Preparation of formulations - Characterization and stability of the employed formulations - Cryo-transmission electron microscopy (TEM) - Mean droplet size, PDI and pH - Rheological properties - Effect of formulations on skin parameters: study design - Effect of formulations on skin parameters: biophysical analysis - Confocal Raman spectroscopy (CRS) - Calculation of skin parameter changes - Statistical analysis
- RESULTS AND DISCUSSION : Formulation development and characterization - Effect on physiological skin parameters
- Table 1 : Composition of the investigated formulations in % w/w |
| DOI : |
https://doi.org/10.1111/ics.12674 |
| En ligne : |
https://drive.google.com/file/d/1w4WxWstTSlMkwISgKXc12tp01lmVp-Q5/view?usp=shari [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35766 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° 2 (04/2021) . - p. 263-268
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