The human melanocyte and melanoblast populations per unit area of epidermis in the rete ridge are greater than in the inter-rete ridge / Tomohisa Hirobe in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° 2 (04/2021)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° 2 (04/2021) . - p. 211-217 Titre : The human melanocyte and melanoblast populations per unit area of epidermis in the rete ridge are greater than in the inter-rete ridge Type de document : document électronique Auteurs : Tomohisa Hirobe, Auteur ; Hisao Enami, Auteur ; Ai Nakayama, Auteur Année de publication : 2021 Article en page(s) : p. 211-217 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cheveux -- Croissance Dermatologie Dopa La 3,4-dihydroxyphénylalanine (abréviée en DOPA ou dopa) est une substance intermédiaire dans la synthèse des catécholamines. Elle possède deux isomères optiques, la L-DOPA ou L-dopa (ou lévodopa, dénomination pharmacologique internationale), lévogyre, et la D-DOPA ou D-dopa, dextrogyre. La L-DOPA est la forme stéréo-isomérique lévogyre métabolisable par l'organisme. Sa décarboxylation par la DOPA-décarboxylase produit la dopamine. La L-DOPA est capable de franchir la barrière hémato-encéphalique. C'est une substance qui est utilisée dans le traitement de la maladie de Parkinson en augmentant le taux de dopamine. Epiderme Génétique Peau -- Physiologie Pré-mélamine Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : In human skin, melanocytes and melanoblasts are mostly located in the epidermis in addition to hair follicles. In hairy skin such as mouse skin, the inter-follicular epidermis is generally flat. In contrast, in human skin, the epidermis is wavy and possesses well-developed rete ridges. It is not well understood what difference exists in cell function between melanocytes present in the inter-rete ridge and those in the rete ridge. To clarify this problem, we first tried to determine the melanocyte and melanoblast populations per unit area of epidermis both in the rete ridge and inter-rete ridge epidermis. - Methods : Thirty-eight samples from normal skin sites of 28 patients (14 males and 14 females) aged from 5 to 76 years were fixed and processed to dopa and combined dopa-premelanin reactions. The numbers of cells positive to the dopa (melanocytes) and combined dopa-premelanin (melanoblasts and melanocytes) reactions were scored. Results : The average melanocyte population/0.1 mm2 of the inter-rete ridge was 74 cells, whereas that of the rete ridge was 147 cells. Moreover, the average melanoblast population/0.1 mm2 in the inter-rete ridge was 43 cells, whereas that of the rete ridge was 131 cells. The melanoblast population in the rete ridge differed between female and male, but the melanocyte populations in the rete ridge and inter-rete ridge and the melanoblast population in the inter-rete ridge did not differ between female and male. However, no age difference in the melanocyte and melanoblast populations was observed between the rete ridge and inter-rete ridge. - Conclusion : Human epidermal melanocytes and melanoblasts in the rete ridge exist more numerously than in the inter-rete ridge. Note de contenu : - MATERIALS AND METHODS : Collection of skin samples - Histochemistry - Statistics - RESULTS : Histochemistry of human skin - The melanocyte and melanoblast populations in the rete ridge and inter-rete ridge - Gender difference in the melanocyte and melanoblast populations - Age difference in the melanocyte and melanoblast populations - Table 1 : Number of human melanocytes and melanoblasts in the inter-rete ridge (IRR), rete ridge (RR) and whole epidermis in addition to the ratio of RR to IRR of melanocytes and melanoblasts of several normal skin sites - Table 2 : Gender difference in the number of human melanocytes and melanoblasts in the inter-rete ridge (IRR), rete ridge (RR) and whole epidermis in addition to the ratio of RR to IRR of melanocytes and melanoblasts of several normal skin sites DOI : https://doi.org/10.1111/ics.12682 En ligne : https://drive.google.com/file/d/1ZE_ma87CEm7vIdQCQ6uL4l_Fzubr-yPi/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35764 [article]

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