A novel patented ingredient targeting multifaceted mechanism for healthy scalp / Emily Yi in SOFW JOURNAL, Vol. 147, N° 4 (04/2021)  

[article]  inSOFW JOURNAL > Vol. 147, N° 4 (04/2021) . - p. 10-14 Titre : A novel patented ingredient targeting multifaceted mechanism for healthy scalp Type de document : texte imprimé Auteurs : Emily Yi, Auteur ; Debby Kuo, Auteur ; Snow Hsieh, Auteur Année de publication : 2021 Article en page(s) : p. 10-14 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antipelliculaires Biomolécules actives Cosmétiques Cuir chevelu -- Soins et hygiène Dermo-cosmétologie Homéostasie L'homéostasie (du grec "hómoios", "similaire", et "stásis", "stabilité, action de se tenir debout") est la capacité que peut avoir un système quelconque (ouvert ou fermé) à conserver son équilibre de fonctionnement en dépit des contraintes qui lui sont extérieures. L'homéostasie est la maintenance de l'ensemble des paramètres physico-chimiques de l'organisme qui doivent rester relativement constants (glycémie, température, taux de sel dans le sang, etc.). Malassezia Index. décimale : 668.5 Parfums et cosmétiques Résumé : Ahealthy scalp also means healthy hair and is free from troubling scalp conditions, like itchiness, redness, oiliness, flakiness, burning or painful sensation, hair damage and hair thinning. Good scalp health is closely associated with sebum normalization, microbiota balance and low inflammation. The latest proprietary ingredient Epi-Onâ„¢ developed by Corum aims to promote healthier scalp condition through its multifaceted properties to reduce sebum secretion, inhibit scalp yeast Malassezia, mitigate inflammation and downregulate 5-alpha reductase activity. 2% Azelamidopropyl Dimethyl Amine in serum delivered outstanding performance in clinical trial to significantly reduce sebum, redness, and dandruff after 14 days and 28 days. Advance research further indicates Azelamidopropyl Dimethyl Amine not only acts as an ideal solution for hair care formulation to help maintain scalp health and tackle scalp problems but also act as a cosmetic active to enhance skin recovery through epigenetic pathway. Note de contenu : - Fig. 1 : Three major mechanisms of scalp problem: sebum secretion, Malassiezia spp. proliferation and Inflammation - Fig. 2 : The detail mechanism of lipids degradation via Malassezia spp. growth and dandruff production - Fig. 3 : Epi-Onâ„¢ decreased intracellular lipid droplets in human primary sebocytes in a dose-dependent manner - Fig. 4 : Epi-Onâ„¢ inhibits amount of Malassezia spp. in 24hr and 48hr at 0.1% and 0.5% treatment - Fig. 5 : Epi-Onâ„¢ decreased two inflammatory cytokines IL-6 and IL-8 proteins on squalene peroxides stimulation - Fig. 6 : 0.6%, 0.4%, and 0.2% Epi-Onâ„¢ decreased 5-alpha reductase activity to 67%, 81%, and 92%, respectively - Fig. 7 : Epi-Onâ„¢ has a much better performance to significantly decrease the sebum level, decrease the redness and dandruff score - Fig. 8 : A dandruff score standard criteria: 1 - VERY SLIGHT (observe carefully to see the microscale), 2 - SLIGHT (Mild dandruff on the scalp), 3 - MODERATE (more dandruff on the scalp), 4 - SEVERE (much dandruff, spread on scalp and hair) and 5 - VERY SEVERE (b) Compared to placebo, 4% Epi-Onâ„¢ significantly decrease the redness after 14 and 28 days En ligne : https://drive.google.com/file/d/1JCJoWWJJXOve6gNVY7bR-3rUDj5YHDzj/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35567 [article]

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