Preparation and evaluation of caffeine bioadhesive emulgels for cosmetic applications based on formulation design using QbD tools / Y. de Lafuente in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 42, N° 6 (12/2020)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 42, N° 6 (12/2020) . - p. 548-556 Titre : Preparation and evaluation of caffeine bioadhesive emulgels for cosmetic applications based on formulation design using QbD tools Type de document : document électronique Auteurs : Y. de Lafuente, Auteur ; Maria Emma Parente, Auteur ; M. C. Palena, Auteur ; A. F. Jimenez-Kairuz, Auteur Année de publication : 2020 Article en page(s) : p. 548-556 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Adhésifs biologiques Caféine Caractérisation Cosmétiques Emulsions -- Stabilité Formulation (Génie chimique) Gels -- Emploi en cosmétologie Médicaments -- Administration par voie cutanée Médicaments dermatologiques Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : The aim of the present study was to evaluate the influence of the incorporation of caffeine as a model active ingredient on the quality attributes of a bioadhesive emulgel formulation previously optimized by Quality by Design (QbD) tools. Emulgels are emerging topical drug delivery systems for cosmetic or pharmaceutical uses, which combine the advantages of both emulsions and gels. - Methods : In this work, the observed and predicted values for spreadability, phase separation by centrifugation and detachment forces performed by texturometer were compared with those of the control and active‐containing emulgel formulations. In addition, rheological properties, release of caffeine and comparative in vitro/ex vivo bioadhesion properties were evaluated using human skin. - Results : The flow curves of emulgel formulations showed the typical pseudoplastic and no thixotropic flow with yield stress. The incorporation of active ingredient did not produce significant changes. All emulgels were uniformly spread and no significant differences in spreadability values between control and caffeine containing formulations and neither respect to those predicted values from experimental design optimization were found. Emulgel formulations showed appropriate detachment forces values and no significant differences between caffeine loading and control emulgel formulations were observed. - Conclusion : Caffeine was successfully vehiculized in this optimized bioadhesive emulgel formulation, which showed high robustness regarding the process variability. There were no significant changes in the critical quality attributes after the incorporation of the active ingredient and a promising stability was observed for at least one year. Results suggested that the optimized emulgel is an interesting topical biodhesive delivery system for cosmetic applications, including agents for skin conditioning, not present in gels formulations. Note de contenu : - MATERIALS AND METHODS : Materials - Preparation of emulgels - Preparation of compounded creams - Characterization of emulgels - Skin membrane preparation - Determination of Caffeine concentration by HPLC - Stability evaluation - Data analysis - RESULTS AND DISCUSSION : Rheological studies - Spreadability - Physical stability - Adhesion and bioadhesion properties - Drug release studies - Stability evaluation - Table 1 : Qualitative and quantitative formula of optimized emulgel - Table 2 : Quality attributes of freshly prepared emulgels (time = 0) and stored at 25°C and 60% RH during 1 year. Data expressed as main values with standard deviations (N = 3) - Table 3 : Detachment forces (Fdetach) of emulgel and compounded creams loaded with CAF and control formulations, measured at 32°C - Table 4 : In vitro release parameters of caffeine from emulgel and compounded cream using diffusional Higuchi kinetic model. Both formulations contained 10 mg mL-1 of caffeine DOI : https://doi.org/10.1111/ics.12638 En ligne : https://drive.google.com/file/d/1kDZNJlS5f3c8X1MarU4uVFf8JZ4POw7R/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35420 [article]

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