| Titre : |
Dermal delivery system of the future : Peptides steer efficacy to the point |
| Type de document : |
texte imprimé |
| Auteurs : |
Sandra Christian, Auteur ; Volker Krug, Auteur ; Alfons Hidalgo, Auteur |
| Année de publication : |
2020 |
| Article en page(s) : |
p. 8-14 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge:Antirides
Biomolécules actives
Cosmétiques -- Administration par voie cutanée
Dermo-cosmétologie
Encapsulation
Franz, Cellules de
Peau -- Soins et hygiène
Peptides
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Modern active based cosmetics are characterized by increasing demands on their performance. Therefore, the efficacy of cosmetic active ingredients plays a key role in the development of new technologies. Penetration and the release of the active ingredients in the skin are important parameters in this context. These challenges can already be met successfully with the help of dermal delivery systems, in which the active ingredients are usually encapsulated. The X50 Capsulesâ„¢ go one step further. By means of specific steering peptides on the capsule surface, it is possible to selectively transport the respective active ingredient to certain cells in the skin and thus directly to its corresponding site of action. The active ingredient is released inside the cell so that its full potential is developed where it is needed. The biocompatible and biodegradable capsule also prevents interactions between the active ingredient and the product formulation and protects the active from functional degradation on its way from the skin surface to its specific site of action in the cell. This selective and efficient approach can also prevent unspecific cell reactions as side effects and reduce dosages cost-effectively. Various in vitro and in vivo studies confirm the efficacy of this pioneering delivery system, which can revolutionize the efficiency of cosmetic active ingredients in a unique way. |
| Note de contenu : |
- INTRODUCTION : Effect and efficacy - a small but crucial difference - Active availability selectively as far as the cell level
- METHODS AND RESULTS : Proven increase of efficacy through improved penetration and specific cell bindings - One technology, many actives - X50 capsules as universal delivery system
- Table 1 : Overview of the INFINITEC X50 capsules with various active ingredients, cell selectivity and cosmetic application
- Fig. 1 : Schematic description of the X50 capsule structure and function as well as the "Schlüssel-Schloss-Prinzip" (lock and key principle)
- Fig. 2 : Selective active delivery as far as the inside of the target cell
- Fig. 3 : In vitro skin penetration studies of X50 capsules with and without steering peptides (Franz cell, OECD 428 guideline, fluorescence analysis)
- Fig. 4 : Confocal microscope images of skin tissue cross-sections taken in the same time frame (in vitro skin penetration studies, Franz cell, fluorescent labelling of the X50 capsules). X50 capsules without steering peptides and X50 capsules with steering peptides
- Fig. 5 : Cell selectivity of the X50 capsules with steering peptides for fibroblasts (in vitro fluorescence labelling)
- Fig. 6 : Increased efficacy due to X50 capsules with steering peptides (fibroblast cultures ; quantitative measurement of collagen type I snthesis via ELISA assay)
- Fig. 7 : Selected test results of the in vivo study on the reduction of expression lines (crow's feet). Before and after four weeks of application of the test product and corresponding fringe projections |
| En ligne : |
https://drive.google.com/file/d/18CcLCbGOZ3E1VKBzx7ts8uZVUDdOSEoJ/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=34222 |
in SOFW JOURNAL > Vol. 146, N° 6 (06/2020) . - p. 8-14
Aller sur edunet
Accueil
Ajouter le résultat dans votre panier Affiner la recherche
