Design of leather footwear for diabetics containing chlorhexidine digluconate microparticles / Fatih Yalcin in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA), Vol. CXV, N° 3 (03/2020)  

[article]  inJOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA) > Vol. CXV, N° 3 (03/2020) . - p. 79-86 Titre : Design of leather footwear for diabetics containing chlorhexidine digluconate microparticles Type de document : texte imprimé Auteurs : Fatih Yalcin, Auteur ; Huseyin Ata Karavana, Auteur ; Seda Rencber, Auteur ; Sinem Yaprak Karavana, Auteur Année de publication : 2020 Article en page(s) : p. 79-86 Note générale : Bibliogr. Langues : Américain (ame) Catégories : Antiseptiques Caractérisation Chaussures -- Conception et construction Cuir Diabète Digluconate de chlorhexidine Encapsulation Ethylcellulose Formulation (Génie chimique) Matériaux -- Imprégnation Microbiologie Particules (matières) Pieds -- Soins et hygiène Système de libération contrôlée (technologie) Index. décimale : 675 Technologie du cuir et de la fourrure Résumé : ChlorHexidine Digluconate [CHD] was encapsulated inside an ethylcellulose shell material [Aquacoat ECD], and then spray dried to produce mixed microparticles (MPs). The validity and functional quality of the resultant [CHD-MPs] were analyzed on vamp and lining leather which are used to manufacture shoes for diabetics. The morphology, efficiency of encapsulation and in vitro release characteristics of the [CHD-MPs] were optimized in order to impregnate [CHD-MPs] onto leather footwear for diabetics. Scanning electron microscopy (SEM) was used to characterize the [CHD-MPs] and the leathers treated with it. SEM images illustrated that the [CHD-MPs] were spherical, smooth in shape and adhered well to leather. In vitro CHD-release studies from its MPs, and for leather treated with it were performed in phosphate buffer saline at pH =7.2. There was an inherently controlled release behaviour of CHD for all the formulations on leather. Finally, microbiologic studies on leather treated with [CHD-MPs] were done. This study suggested that footwear containing [CHD- MPs] is/will improve the quality of daily life for diabetics. Note de contenu : - EXPERIMENTAL : Materials - METHODS : Prepration of MPs - Particle morphology of the MPs - Conditions of Ultra-Performance Liquid Chromatography (UPLC) - Encapsulation efficiency of the MPs - FT-IR analysis - In vitro drug release of the MPs - Application of the MPs on the leathers - Scanning Electron Microscopy (SEM) of the leathers with the MPs - In vitro drug release of the leathers with MPs - Microbiologic studies on leathers with MPs - RESULTS AND DISCUSSION : Particle morphology - UPLC conditions - Encapsulation efficiency - Fourier Transform Infrared Spectroscopy (FT-IR) - In vitro drug release of the MPs - SEM of the leathers with the MPs - In vitro drug release of the leathers impregnated with MPs - Microbiologic studies on leathers with MPs DOI : https://doi.org/10.34314/jalca.v115i03.1625 En ligne : https://drive.google.com/file/d/1bMgMmBeb608l3LTX7OTST1S0mMdLW9-K/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33885 [article]

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