| Titre : |
High wavelength high blue light induced damages in human skin |
| Type de document : |
texte imprimé |
| Auteurs : |
Hanane Chajra, Auteur ; David Garandeau, Auteur ; Mathilde Fréchet, Auteur ; Francine Joly, Auteur |
| Année de publication : |
2020 |
| Article en page(s) : |
p. 26-33 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Dermatologie
Diodes électroluminescentes
Extraits de plantes:Extraits (pharmacie)
Lumière artificielle -- Effets physiologiques
Lumière bleue
Peau -- Histologie
Photodétérioration
Photovieillissement (dermatologie)
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
In our hyper-connected world, we spend countless hours in front of digital screens emitting blue light (BL) with the general perception that this is safe for our skin, but the infiltration of electronic devices in our daily lives does not come without consequence. There is scarce data that touches on the effects of BL on human skin. Moreover, the data available so far has been performed on basic cellular models that are far from the complexity of human skin. This study focuses on the identification of the BL induced damage using 3D models. We found that direct BL exposure to the skin generates ROS leading to oxidative stress marker generation including protein carbonylation, nitrotyrosine, 4-hydroxynonenal. In addition, the expression of matrix metalloproteinase-1 which is responsible for extracellular matrix degradation during chronological aging and photoaging processes is increased. These data show that blue light emitted by electronic devices affect skin health and may be involved in premature aging. |
| Note de contenu : |
- RESULTS AND DISCUSSION : LED-BL induces intracellular reactive oxygen species generation in human keratinocytes - LED-BL induces oxidative damage in human skin - Oxidative stress induced by LED-BL leads to protein damage in dermis and epidermis via the release of 4-Hydroxy-2-Nonenal (4-HNE) - LED-BL is a potent inducer of skin damage through
MMP-1 overexpression and protein oxidation - LED-BL induces similar effects as UVB irradiation in skin suggesting a potential role in triggering premature aging - Skin damage induced by blue light can be easily prevented or limited by the use of cosmetic products
- MATERIALS AND METHODS : Description of light-emitting diode generated blue light (LED-BL) device used in the experimental studies - Plant extract description - Monolayer keratinocyte's model exposed to blue light - Human skin explants - Histological processing of skin samples - Image acquisition and quantification
- Fig. 1 : Light emitting diode emission spectra
- Fig. 2 : Measurement of intracellular reactive oxygen species generated using H2DCF-DA fluorescent probe
- Fig. 3 : Visualization and quantification of oxidative stress markers in human skin explants exposed or not to blue light |
| En ligne : |
https://drive.google.com/file/d/18XwQGr3LZVYDLSJgU9Xs82tQNvO9PlmR/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33756 |
in SOFW JOURNAL > Vol. 146, N° 1-2 (01-02/2020) . - p. 26-33
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