| Titre : |
A natural skin anti-ageing serum containing pseudobulb ethanolic extract of Grammatophyllum speciosum : a randomized double-blind, placebo-controlled trial |
| Type de document : |
texte imprimé |
| Auteurs : |
V. Chowjarean, Auteur ; P. P. Phiboonchaiyanan, Auteur ; S. Harikarnpakdee, Auteur ; Parkpoom Tengamnuay, Auteur |
| Année de publication : |
2019 |
| Article en page(s) : |
p. 548-557 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Analyse quantitative (chimie)
Antiâge:Antirides
Antioxydants
Biomolécules actives
Cellules -- Cultures et milieux de culture
Dermo-cosmétologie
Etudes cliniques
Peau -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : Grammatophyllum speciosum is utilized to treat sore throats and bronchitis In Thai folk medicine. This study evaluated the in vitro activity and clinical efficacy of a G. speciosum pseudobulb decoction.
- Methods : Measure of in vitro anti-ageing activity was performed using non-cell based assays as well as in CRL 2097 human fibroblast cells. A prophetic patch test method was used to determine skin irritation in 24 healthy Thai volunteers. A randomized double-blind, placebo-controlled trial was conducted with 24 subjects for 56 days after facial application to evaluate efficacy. The results were measured with Visioface® and Cutometer® MPA 580 as well as by visual observations.
- Results : The total content of the antioxidant polyphenols in G. speciosum ethanolic extract (GSE) was 48.19 ± 0.39 mg EGCG equivalent per gram. The GSE possessed potent and higher anti-elastase activity more than EGCG. The extract was able to protect human fibroblasts against superoxide anion-induced cell death at the concentration of 10 µg mL-1. In a clinical study, facial application of the serum containing 0.5% GSE was found to safely increase skin distensibility in healthy volunteers. Skin viscoelasticity and wrinkle volume were also significantly reduced (P < 0.05).
- Conclusion : Thus, both the in vitro and the clinical studies have illustrated the anti-wrinkle/anti-ageing benefits of GSE on human skin. |
| Note de contenu : |
- MATERIALS AND METHODS : Plant material preparation of G. speciosum pseudobulb extract - Quality control of G. speciosum bulb extract - Non-cell-based assays - Cell-based assay in skin fibroblast cellline - Stability and physicochemicl characteristic of the G. speciosum - Stability of serum containing G. speciosum extract - Clinical trial testing - Sensory and visual assessment - Statistical analysis |
| DOI : |
10.1111/ics.12571 |
| En ligne : |
https://drive.google.com/file/d/1MX3zh0VXFywQ_fHe-7rgmznojbYxjwzm/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33663 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 41, N° 6 (12/2019) . - p. 548-557
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