[article]
| Titre : |
A new peptide mimicking a good sleep in times of pandemia |
| Type de document : |
texte imprimé |
| Auteurs : |
Miriam Mateu, Auteur ; Patricia Carulla, Auteur ; Marco J. Klein, Auteur ; Ariadna Grau-Campistany, Auteur ; Silvia Pastor, Auteur ; Meritxell Llinas, Auteur |
| Année de publication : |
2020 |
| Article en page(s) : |
p. 14-19 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Glycation
Inflammation
InterleukinesLes interleukines (IL) sont un groupe de cytokines, ainsi nommées car les premières observations semblaient montrer qu'elles étaient exprimées par les globules blancs (leucocytes, d'où -leukin) en guise de moyen de communication (d'où inter-). Les interleukines sont produites par une large variété de tissus et cellules, et que, bien que regroupées sous cette terminologie par commodité, elles ne présentent aucune parenté biochimique ni de fonction entre elles. Elles ont été classées par numéro au gré des découvertes. Au début 2006, 31 cytokines sont connues et dénommées sous l'intitulé IL.
La fonction du système immunitaire dépend en grande partie des interleukines et de rares déficiences de certaines d'entre elles ont été décrites, conduisant à des maladies auto-immunes ou des immunodéficiences.
Mélatonine
Peptides
Sommeil
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Regularly skipping sleep is associated with chronic low inflammation, oxidative stress and weakened immune system. These three factors are interconnected and all of them generate further inflammation, oxidative stress and worsen the immune system.
The alarmin interleukin IL-33 is a pro-inflammatory cytokine released upon cell damage activating the immune response and inducing oxidative stress and further inflammation. IL-33 is over-expressed in conditions of chronic inflammation like a topic dermatitis and obstructive sleep apnea.
Sleep disturbance also presents high levels of glucose which may glycate proteins of the skin and the endothelial and lymphatic vessels, weakening their integrity and producing oxidative stress and more inflammation. In addition, melatonin levels are decreased, which not only affects its circadian role but also as a potent antioxidant and antiglycant.
iPeptideâ„¢ is a peptide that was discovered to down-regulate IL-33 expression through a Big Data analysis. It showed to modulate chronic inflammation and damages induced by hyperglycemia due to sleep deprivation. It also presented a melatonin-like protection effect and reinforced the first line of immune defense. In vivo, it decreased fatigue features, awakened sleepy lookand had a local cool effect. |
| Note de contenu : |
- MATERIALS AND METHODS : Gene expression modulation of sleep deprivation – Modulation of IL-33 release – Regulating hyperpigmentation – De-stressing capillarity – Reinforcing lymphatic integrity – Melatonin-like protection against glycation and lipid peroxidatione – Melatonin-like modulation of the epidermal immune protection – Guarding from hyperglycemia damage – Anti-fatigue efficacy in sleep deprived volunteers – Refreshing effect in sleep deprived volunteers
- RESULTS AND DISCUSSION : Gene expression modulation of sleep deprivation – Modulation of IL-33 release – Regulating hyperpigmentation – De-stressing capillarity – Reinforcing lymphatic integrity – Melatonin-like protection against glycation and lipid peroxidation – Melatonin-like modulation of the epidermal immune protection – Guarding from hyperglycemia damage – Anti-fatigue efficacy in sleep deprived volunteers – Refreshing effect in sleep deprived volunteers
- Fig. 1 : Melatonin-like protection of the peptide against glycationand lipid peroxidation
- Fig. 2 : Protection against glycation of human skin explants treated with MGO and non-treated and treated with 0.005 mg/mL ofpeptide. Fibrillin-1 in green
- Fig. 3 : Increase of the angle of the eye opening (+21%) in a 59-year-old volunteer before applying a cream with 0.015 mg/m/ of peptide and after 28 days
- Fig. 4 : Fatigue features improvement, which is the average of tiredness, dark circles, eyebags and wrinkles
- Fig. 5 : Local cooling effect (-0.7°C) in a volunteer of 35 years old before applying a cream with 0.015 mg/mL of peptide and after 28 days
- Fig. 6 : Dark circles improvement in a 37-year-old volunteer applying a cream with 0.015 mg/mL of peptide and after one week |
| En ligne : |
https://drive.google.com/file/d/1mOAQywzRfktLYNaWWiMLmZWyVYXfSm75/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35002 |
in SOFW JOURNAL > Vol. 146, N° 12 (12/2020) . - p. 14-19
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