A novel epigenetic-regulating active for repairing weakened and damaged skin / Snow Hsieh in SOFW JOURNAL, Vol. 145, N° 3 (03/2019)  

[article]  inSOFW JOURNAL > Vol. 145, N° 3 (03/2019) . - p. 16-22 Titre : A novel epigenetic-regulating active for repairing weakened and damaged skin Type de document : texte imprimé Auteurs : Snow Hsieh, Auteur ; Kuan-Yi Yeh, Auteur Année de publication : 2019 Article en page(s) : p. 16-22 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anti-inflammatoires Biomolécules actives Cicatrisation Cosmétiques Dermo-cosmétologie Peau -- Soins et hygiène Régénération (biologie) Index. décimale : 668.5 Parfums et cosmétiques Résumé : Skin lesions not only have negative social and psychological ramifications on both men and women but may also cause irritation, discomfort, burn and even pain. Uneven skin tone, pigmentation, fine lines and wrinkles as well as scaling and flaky skin are all considered signs of imperfect skin, but one of the more permanent types of skin damage is skin lesions that may potentially lead to severe scarring. These scars are typically punctured deep and can only be removed through a series or combination of clinical procedures. Even to a less severe extent, skin lesions may leave skin with temporary pigmentation, marks and blemishes. If appropriate treatment is not applied on the damaged skin site, skin lesions, especially those resulting from inflamed acnes, may leave large surface of skin rough and bumpy. Besides naturally occuring skin damage, there are numerous clinical procedures, such as laser treatment, skin needling or microdermabrasion, aiming at weakening or destroying the stratum corneum or slightly deeper skin layer to trigger the innate rejuvenating and healing mechanism of skin. This post-procedure skin undergoing dermabrasion or laser treatment is slightly inflamed on the surface and typically sensitive, as the skin barrier was dwindled and enfeebled. Regardless of the perpetual tendency for human to pursue beauty defined by flawless skin or the contemporary concept of wellness and healthy living, the marks and scars as well as the weakened, damaged or disfigured surface left on the skin instigate negative psychological impacts and sequelae in the forms of embarrassment, impaired self-image, low self-esteem or even anxiety. Therefore, soothing and repairing weakened skin as well as damaged skin has been an important area for cosmetic development. Note de contenu : - MECHANISM OF SKIN REPAIR & SCARRING - EPIGENIC REGULATION & PROPERTIES OF EPI-ON - IN VITRO STUDIES:SKIN REPAIR AND PROTECTIVE EFFECT VIA EPIGENIC PATHWY : Epi-On upregulates expression of growth factor and accelerates tissue regeneration throught epigenetic regulation - Epi-On promotes profiferation and migration of both Keratinocytes and Fibroblasts - IN VITRO STUDIES:ANTI-INFLAMMATORY & 5α-REDUCTASE INHIBITION : Epi-On attenuates inflammatory reactions - Epi-On reduces 5α-reductase activity - EX VIVO STUDY:SKIN REPAIR AND BARRIER STRENGTHENING ACTIVITIES ON HUMAN SKIN EXPLANTS - Fig. 1 : The cutaneous wound healding is a complex and dynamic process, comprising three major overlapping phases: (A) inflammation phase, where blood clot starts forming and leukocytes triggers inflammatoty responses; (B) cell proliferation, phase, where new fibroblast grows contributing to tissue formation; and (C) matrix remodeling, where the contraction and closure of wound site can be observed as neoepidermis and/or scar tissue forms. - Fig. 2 : Epi-On attenuated HDAC activity of HaCaT (crude nuclear extract) in dose-depend manner. An effective HDAC inhibitor Trichostatin A (TsA) was used as positive control of this HDAC activity. - Fig. 3 : Epi-On up-regulated the acetylation of (A) HAK16 in HaCaT cell line and (B) Hs68 cell line. Trichostain A (TsA) was used as the positive control of the western blot assay. - Fig. 4 : (A) Representative western blot bands of H4K16ac and β-actin of H2O2-induced NHDF after Epi-On treatment. (B) H2O2 was used to remove the acetyl group from H4K16, and Epi-On inhibit H2O2-triggered H4K16ac deacetylation in NHDF in dose-dependent manner. - Fig. 5 : (A) Microscopic images of wounded monolayer keratinocytes (HaCaT) after Epi-On treatment (24hr) and (B) 5,05% Epi-On (Al) significantly promoted proliferation and migration on keratinocytes cell line (+153,9%) - Fig. 6 : (A) Microscopic images of wounded monolayer fibroblasts (Hs68) after Epi-On treatment (18hr) and (B) 0,05% Epi-On (Al) significantly promoted proliferation and migration on fibroblasts cell line (+84,4%) - Fig. 7 Epi-On significantly reduced two inflammatory cytokines IL-6 and IL-8 proteins on LPS-treated HaCaT cell line to 72,7% and 73,5%, respectively - Fig. 8 : 0,6%, 0,4% and 0,2% Epi-On decreased 5alpha-reductase activity to 66,6%, 81,5% and 91,7% respectively. 5alpha-reductase is an enzyme responsible for converting testosterone to dihydrotestosterone (DHT), which can potentially inhibit re-epitheliazation. - Fig. 9 : The application of 4% Epi-On progressively and significantly promoted the thickening of stratum corneum as protective barrier on Day 3 and Day 10, as shown by the top-layered red stains. - Table 1 : Summary of growth factor gene expression result - these genes are involved in the proliferation and differentiation of keratinocytes and fibroblast. En ligne : https://drive.google.com/file/d/1p3Tm7SHQsTUhuJnIg3sBm8dtyu63ocsF/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=32000 [article]

Réservation

Réserver ce document

Exemplaires (3)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
20809	-	Périodique	Bibliothèque principale	Documentaires	Disponible
20688	-	Périodique	Bibliothèque principale	Documentaires	Disponible
20697	-	Périodique	Bibliothèque principale	Documentaires	Disponible

A novel patented ingredient targeting multifaceted mechanism for healthy scalp / Emily Yi in SOFW JOURNAL, Vol. 147, N° 4 (04/2021)  

[article]  inSOFW JOURNAL > Vol. 147, N° 4 (04/2021) . - p. 10-14 Titre : A novel patented ingredient targeting multifaceted mechanism for healthy scalp Type de document : texte imprimé Auteurs : Emily Yi, Auteur ; Debby Kuo, Auteur ; Snow Hsieh, Auteur Année de publication : 2021 Article en page(s) : p. 10-14 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antipelliculaires Biomolécules actives Cosmétiques Cuir chevelu -- Soins et hygiène Dermo-cosmétologie Homéostasie L'homéostasie (du grec "hómoios", "similaire", et "stásis", "stabilité, action de se tenir debout") est la capacité que peut avoir un système quelconque (ouvert ou fermé) à conserver son équilibre de fonctionnement en dépit des contraintes qui lui sont extérieures. L'homéostasie est la maintenance de l'ensemble des paramètres physico-chimiques de l'organisme qui doivent rester relativement constants (glycémie, température, taux de sel dans le sang, etc.). Malassezia Index. décimale : 668.5 Parfums et cosmétiques Résumé : Ahealthy scalp also means healthy hair and is free from troubling scalp conditions, like itchiness, redness, oiliness, flakiness, burning or painful sensation, hair damage and hair thinning. Good scalp health is closely associated with sebum normalization, microbiota balance and low inflammation. The latest proprietary ingredient Epi-Onâ„¢ developed by Corum aims to promote healthier scalp condition through its multifaceted properties to reduce sebum secretion, inhibit scalp yeast Malassezia, mitigate inflammation and downregulate 5-alpha reductase activity. 2% Azelamidopropyl Dimethyl Amine in serum delivered outstanding performance in clinical trial to significantly reduce sebum, redness, and dandruff after 14 days and 28 days. Advance research further indicates Azelamidopropyl Dimethyl Amine not only acts as an ideal solution for hair care formulation to help maintain scalp health and tackle scalp problems but also act as a cosmetic active to enhance skin recovery through epigenetic pathway. Note de contenu : - Fig. 1 : Three major mechanisms of scalp problem: sebum secretion, Malassiezia spp. proliferation and Inflammation - Fig. 2 : The detail mechanism of lipids degradation via Malassezia spp. growth and dandruff production - Fig. 3 : Epi-Onâ„¢ decreased intracellular lipid droplets in human primary sebocytes in a dose-dependent manner - Fig. 4 : Epi-Onâ„¢ inhibits amount of Malassezia spp. in 24hr and 48hr at 0.1% and 0.5% treatment - Fig. 5 : Epi-Onâ„¢ decreased two inflammatory cytokines IL-6 and IL-8 proteins on squalene peroxides stimulation - Fig. 6 : 0.6%, 0.4%, and 0.2% Epi-Onâ„¢ decreased 5-alpha reductase activity to 67%, 81%, and 92%, respectively - Fig. 7 : Epi-Onâ„¢ has a much better performance to significantly decrease the sebum level, decrease the redness and dandruff score - Fig. 8 : A dandruff score standard criteria: 1 - VERY SLIGHT (observe carefully to see the microscale), 2 - SLIGHT (Mild dandruff on the scalp), 3 - MODERATE (more dandruff on the scalp), 4 - SEVERE (much dandruff, spread on scalp and hair) and 5 - VERY SEVERE (b) Compared to placebo, 4% Epi-Onâ„¢ significantly decrease the redness after 14 and 28 days En ligne : https://drive.google.com/file/d/1JCJoWWJJXOve6gNVY7bR-3rUDj5YHDzj/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35567 [article]

Réservation

Réserver ce document

Exemplaires (1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
22654	-	Périodique	Bibliothèque principale	Documentaires	Disponible

---

1 (1 - 2 / 2)