Biohacking sleep for a restored eye area / Miriam Mateu in GLOBAL PERSONAL CARE, Vol. 22, N° 5 (05/2021)  

[article]  inGLOBAL PERSONAL CARE > Vol. 22, N° 5 (05/2021) . - p. 59-60 Titre : Biohacking sleep for a restored eye area Type de document : texte imprimé Auteurs : Miriam Mateu, Auteur ; Patricia Carulla, Auteur ; M. J. Klein, Auteur ; Ariadna Grau-Campistany, Auteur ; Silvia Pastor, Auteur ; Meritxell Llinas, Auteur Année de publication : 2021 Article en page(s) : p. 59-60 Langues : Anglais (eng) Catégories : Anti-inflammatoires Cernes Contour des yeux -- Soins et hygiène Cosmétiques Dermo-cosmétologie Glycation Peptides Pigmentation, Troubles de la Index. décimale : 668.5 Parfums et cosmétiques Résumé : It is well known that an adequate amount and quality of sleep is key to repairing the damage inflicted to the body during the day. However, it is difficult to really enjoy a regularly undisturbed sleep of 7-9 hours per night. A survey conducted among adults in 13 countries revealed that on average, people sleep 6.8 hours per weeknight and 7.5 hours per weekend night. Hence, the amount of sleep lost during the working week is not compensated over the weekend. Moreover, only 49% of adults are satisfied with their sleep. The recent COVID-19 pandemic has only worsened our sleep quality. Another recent survey among US adults displayed that 98% have developed new sleep problems, and 68% feel it is harder to sleep even after measures were lifted. An additional survey showed that 60% of adults are interested in strategies to sleep better, what is known as biohacking sleep. Note de contenu : - A new tool to 'biohack' sleep - Efficacy studies : Opening the eyes - Attenuation of inflammation - Prevent damage caused by glucose levels - Providing melatonin-like protection - Restoring lymphatic integrity - Capillary de-stressing - Improving hyperpigmentation - Self-assessment - Fig. 1 : Eye-opening effect - Fig. 2 : Efficacy on dark circles - Fig. 3 : Efficacy on hyperpigmentation En ligne : https://drive.google.com/file/d/1RDRoovN5h4MpZK3p6VNSXO-dk_LluOVk/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35818 [article]

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Novel peptide acting on both the pre- and post-synaptic pathways / Miriam Mateu in SOFW JOURNAL, Vol. 145, N° 1-2 (01-02/2019)  

[article]  inSOFW JOURNAL > Vol. 145, N° 1-2 (01-02/2019) . - p. 22-26 Titre : Novel peptide acting on both the pre- and post-synaptic pathways Type de document : texte imprimé Auteurs : Miriam Mateu, Auteur ; Ariadna Grau-Campistany, Auteur ; M. J. Klein, Auteur ; Silvia Pastor, Auteur ; Patricia Carulla, Auteur ; J. A. Boras, Auteur ; Mikel Gorostiaga, Auteur Année de publication : 2019 Article en page(s) : p. 22-26 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge:Antirides Cosmétiques Peau -- Soins et hygiène Peptides Index. décimale : 668.5 Parfums et cosmétiques Résumé : An excess of repeated contraction of the muscles involved in facial expressions results in the appearance of fine lines known as expression wrinkles. Neurotransmission that precedes contraction has been widely studied both in the pre-synaptic neuron and its effects on the post-synaptic muscle. Botulinum toxin treatments have lived together with cosmetic ingredients acting in the pre-synaptic or the post-synaptic pathways to relax muscle contraction and improve the fine lines. Here, we present a peptide, born from in silico design, able to work on both the pre- and post-synaptic pathways and on a new protein in the Cosmetics field Munc 18-1. Munapsys efficacy was tested in vivo against a combination of benchmarks covering both pathways. The peptide demonstrated similar or even better results at a lower concentration. Note de contenu : - MATERIALS AND METHODS : Munc 18-1/Syntaxin-1 binding assay - Pre-synaptic neurotransmitter release - Post-synaptic gene expression modulation - Calcium mobilization in the sarcoplasm - Myosin quantification - Human neuron-muscle contraction - Double-blind assessment of anti-wrinkles efficacy - Proof-of-concept sad smile - RESULTS AND DISCUSSION : Munc 18-1/Syntaxin-1 binding assay - Pre-synaptic neurotransmitter release - Post-synaptic gene expression modulation - Calcium mobilization in the sarcoplasm - Myosin quantification - Human neuron-muscle contraction - Double-blind assessment of anti-wrinkles efficacy - Proof-of-concept sad smile En ligne : https://drive.google.com/file/d/1WxQyw5Fb6uq3I-hisxcN-t4LbSctjrkb/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=31712 [article]

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