| Titre : |
Effects of watercress extract fraction on R-spondin 1-mediated growth of human hair |
| Type de document : |
document électronique |
| Auteurs : |
Masakazu Hashimoto, Auteur ; Yuka Kawai, Auteur ; Teruaki Masutani, Auteur ; Kiyotaka Tanaka, Auteur ; Kenichi Ito, Auteur ; Arunasiri Iddamalgoda, Auteur |
| Année de publication : |
2022 |
| Article en page(s) : |
p. 154-165 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Alopécie
Cheveux -- Croissance
Cheveux -- Soins et hygiène
Cheveux gris
Cresson et constituants
Cuir chevelu -- Soins et hygiène
Extraits de plantes:Extraits (pharmacie)
Produits capillaires
Tests de sécurité
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : Hair loss and greying affect men and women of all ages, often causing psychosocial difficulties. Dickkopf-1 (DKK1), a major hair loss factor secreted from dermal papilla (DP) cells in response to the secretion of dihydrotestosterone (DHT), has been reported to induce and accelerate androgenetic alopecia (AGA). In addition, DKK1 acts as a potent suppressor of melanogenesis and is closely related to hair colour. R-spondin 1 (RSPO1) is a secretory agonist of Wnt signalling known to antagonize the effects of DKK1, including DKK1-mediated hair follicle suppression. In this study, we investigated the effect of watercress extract (WCE) on the secretion of RSPO1 and DKK1 from DP cells as well as its anti-hair loss effect in human hair follicles and patients.
- Methods : The in vitro secretion of RSPO1 and DKK1 was measured by ELISA. Human hair follicles were collected from the scalp of a female donor and used for ex vivo organ culture to investigate the effects of WCE on human hair loss. Finally, a 6-month human clinical trial was conducted to examine the effect of WCE-containing lotion on hair growth in a male panel.
- Results : WCE significantly upregulated RSPO1 secretion and suppressed DKK1 secretion in a dose-dependent manner, even in the presence of DHT. WCE-treated hair follicles elongated 1.6-fold compared with the control, and the level of RSPO1 production in DP as well as RSPO1 bound to the outer root sheath (ORS) increased. In the clinical trial, the hair lotion containing 2% WCE increased hair thickness and density to improve against hair loss symptoms.
- Conclusion : WCE exhibited a strong anti-androgenic effect through its ability to suppress DKK1 secretion and antagonize DKK1 via RSPO1. These findings highlighted the potential use of WCE for the treatment of hair loss. |
| Note de contenu : |
- MATERIALS AND METHODS : Fractionation and identification of WCE components - Treatment with RSPO1, DKK1 and Wnt-3a - Measurements of protein secretion from DP cells - Elongation and immunohistochemistry of hair follicle ex vivo - Statistical analyses
- RESULTS : Enhancement of Wnt signalling by RSPO1 - Effect of WCE on RSPO1 and DKK1 secretion in DP cells - Hair follicle elongation ex vivo - Clinical trial |
| DOI : |
https://doi.org/10.1111/ics.12764 |
| En ligne : |
https://drive.google.com/file/d/1mEtlNb-0EHtJAaI-UEiACOIUsnbeQepv/view?usp=shari [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=37719 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 44, N° 2 (04/2022) . - p. 154-165
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