Anti-inflammatory and scalp care efficacy of a multi-herb extraction against malassezia furfur / Yina Lu in SOFW JOURNAL, Vol. 147, N° 11 (11/2021)  

[article]  inSOFW JOURNAL > Vol. 147, N° 11 (11/2021) . - p. 6-11 Titre : Anti-inflammatory and scalp care efficacy of a multi-herb extraction against malassezia furfur Type de document : texte imprimé Auteurs : Yina Lu, Auteur ; Jun Tian, Auteur Année de publication : 2021 Article en page(s) : p. 6-11 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anti-inflammatoires Biomolécules actives Cosmétiques Cuir chevelu -- Soins et hygiène Dermatite sébhorrhéique Dermatites fongiques Dermo-cosmétologie Eczéma constitutionnel Essais (technologie) Malassezia Index. décimale : 668.5 Parfums et cosmétiques Résumé :  Malassezia furfur is a lipophilic and dermatological pathogenic yeast, which normally exists on human skin, and causes tinea versicolor, seborrhoeic dermatitis, and atopic dermatitis, especially on human scalp. The multi-herb extraction VGP which consists of Vitex trifolia fruit, Gentiana scabra, and Polygonum multiflorum root extract was used to study its effect of anti-inflammation, controlling sebum and dandruff on scalp care. Results showed that on the model of NHEK and THP1 cell inflammation induced by Malassezia furfur, VGP can inhibit the expression of interleukin 6 (IL-6), prostaglandin E2 (PGE-2), monocyte chemoattractant protein 1 (MCP-1) and interleukin 1β (IL-1β) in a dose-dependent manner under 0.01% to 0.125% concentration. On the inflammatory model of 3D reconstructed skin induced by H2O2, VGP significantly improved the cell viability and skin structure, and reduced the production of interleukin 8 (IL-8), PGE-2, and leukotriene B4 (LTB4). During 4 week’s treatment with test shampoo contained 0.5% VGP thrice a week on 16 subjects met with different symptom, VGP reduced the sebum content and TEWL, improved the redness, itching and dandruff on human scalp skin. Therefore, as a natural active ingredient VGP can play a role in scalp care and skin care by targeting inflammation. Note de contenu : - MATERIALS AND METHODS : VGP preparation - Maintenance of cells - Anti-inflammatory experiments on cells - Anti-inflammatory experiments on 3D reconstructed skin - Scalp care test in vivo - Statistical analysis - RESULTS : Anti-inflammatory efficacy of VGP against M. furfur on cells - VGP inhibited the inflammation and cell damage on reconstructed skin - VGP reduced the itching and redness of human scalp skin En ligne : https://drive.google.com/file/d/1fHsMXBQzG3UwovFof_wsjz_WoYMRYdbR/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=36987 [article]

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Antibacterial, anti-keratinized and anti-inflammatory effects of the GMP, a multi-herb extraction on acne vulgaris / Yi-Na Lu in SOFW JOURNAL, Vol. 147, N° 9 (09/2021)  

[article]  inSOFW JOURNAL > Vol. 147, N° 9 (09/2021) . - p. 26-31 Titre : Antibacterial, anti-keratinized and anti-inflammatory effects of the GMP, a multi-herb extraction on acne vulgaris Type de document : texte imprimé Auteurs : Yi-Na Lu, Auteur ; Guang-Yin Wang, Auteur ; Jun Tian, Auteur Année de publication : 2021 Article en page(s) : p. 26-31 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Acné L'acné (nom féminin) est une dermatose (maladie de la peau) inflammatoire des follicules pilosébacés (glandes sécrétant le sébum, à la racine des poils) avec formation de comédons. Cette maladie de la peau est représentée dans sa forme la plus fréquente par l'acné polymorphe juvénile qui touche les adolescents, mais qui ne résume pas toutes les acnés. Il existe aussi des acnés exogènes d'origine professionnelle, médicamenteuse, cosmétique... Anti-inflammatoires Antibactériens Dermo-cosmétologie Kératinisation La kératinisation est la transformation des couches superficielles de la peau (épiderme), ou d'une muqueuse (couche de cellules recouvrant l'intérieur des organes creux en contact avec l'air) qui s'enrichissent progressivement de kératine. Peau -- Soins et hygiène Statistique Index. décimale : 668.5 Parfums et cosmétiques Résumé : Recently reports showed that the pathobiology of acne vulgaris was arising from the exploration of sebaceous gland biology, hormonal factors, hyper-keratinization, and the role of bacteria, sebum, nutrition, cytokines and toll-like receptors (TLRs). Propionibacterium acnes (P. acnes) has a strong proinflammatory activity and targets molecules involved in the innate cutaneous immunity on keratinocytes by acting on TLR-2, leads to the development of comedones. GMP, a multi-herb extraction, targeted most of the major pathogenic features of acne with desired physicochemical traits. It strongly suppressed P. acnes growth, and reduced inflammation by suppressing the TLR-2/NF-κB pathway in SZ-95 sebocytes and HaCaT keratinocytes. GMP exhibited a marginal effect on cell viability and may have modulated hyper-keratinization of the epidermis. These results demonstrate the clinical feasibility of applying GMP for the treatment of acne. Note de contenu : - MATERIALS AND METHODS : Microbial experiments - Cell culture and stimulation - Cell viability test - mRNA expression measurement in HaCaT cells - mRNA expression measurement in SZ-95 cells - ELISA experiments - Statistical analysis - RESULTS : GMP inhibits the growth of P. acnes - GMP promoted the viability of HaCaT cells when stimulated with P. acnes - GMP decreases inflammation induced by P. acnes through the TLR-2 and NF-KB - GMP inhibited the mRNA expression levels related to hyper keratinization En ligne : https://drive.google.com/file/d/1HpLBN6Kcp8YYIvzmLJqBdPHs2cmjfvor/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=36330 [article]

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Promoting effect of a gene expression related moisturizer on skin hydration and barrier function / Yi-Na Lu in SOFW JOURNAL, Vol. 144, N° 9 (09/2018)  

[article]  inSOFW JOURNAL > Vol. 144, N° 9 (09/2018) . - p. 28-32 Titre : Promoting effect of a gene expression related moisturizer on skin hydration and barrier function Type de document : texte imprimé Auteurs : Yi-Na Lu, Auteur ; Ya-Di Yang, Auteur ; Zhi-Yong Xie ; Jun Tian Année de publication : 2018 Article en page(s) : p. 28-32 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Barrière cutanée Cosmétiques Expression génique Peau -- Soins et hygiène Produits hydratants Index. décimale : 668.5 Parfums et cosmétiques Résumé : The moisturizing performance of Gmoist® Sea-Gel was evaluated based-upon 14 healthy volunteers. It was found that skin moisture content markedly increased and TEWL effectively decreased after Gmoist® Sea-Gel applied for 7d. Then using real-time fluorescence quantitative PCR technology, HaCaT cells were cultured with Gmoist® Sea-Gel to study six genes ex¬pression level related to skin hydration and barrier function. Results showed Gmoist® Sea-Gel significantly promoted the INV, TG-1, FLG and CASP-14 mRNA's expression after 24 hour's treatment. Gmoist® Sea-Gel can upregulate cornified cell envelope related genes expression, promote the degradation of filaggrin into natural moisturizing factors to strengthen skin hydration and barrier function. Note de contenu : - In vivo studies - Cell viability test - Gene expression measurement - Gmoist Sea-Gel increased the CM and reduced the TEWL - HaCaT cell toxicity of Gmoist Sea-Gel - Gmoist Sea-Gel regulated the CE formation related gene expression - Gmoist Sea-Gel promoted the FLG degradation - Gmoist Sea-Gel slightly upregulated AQP-3 gene expression En ligne : https://drive.google.com/file/d/1jKk5IrgdBk7as-IStqhBFFLX9mav1AMs/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=30956 [article]

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Scalp care efficacy of a multi-herb extract / Yina Lu in GLOBAL PERSONAL CARE, Vol. 22, N° 6 (06/2021)  

[article]  inGLOBAL PERSONAL CARE > Vol. 22, N° 6 (06/2021) . - p. 33-36 Titre : Scalp care efficacy of a multi-herb extract Type de document : texte imprimé Auteurs : Yina Lu, Auteur ; Zhang Heng, Auteur ; Jun Tian, Auteur Année de publication : 2021 Article en page(s) : p. 33-36 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anti-inflammatoires Cosmétiques Cuir chevelu -- Soins et hygiène Extraits de plantes:Extraits (pharmacie) Malassezia Produits capillaires Statistique Index. décimale : 668.5 Parfums et cosmétiques Résumé : Malassezia furfur is a lipophilic and dermatological pathogenic yeast, which normally exists on human skin, and causes tinea versicolor, seborrhoeic dermatitis, and atopic dermatitis, especially on human scalp. The multi-herb extraction, VGP, which consists of Vitex trifolia fruit, Gentiana scabra, and Polygonum multiflorum root extract was used to study its effect of anti-inflammation, controlling sebum and dandruff on scalp care. Results showed that on the model of NHEK and THP1 cell inflammation induced by Malassezia furfur, VGP can inhibit the expression of interleukin 6 (IL-6), prostaglandin E2 (PGE-2), monocyte chemoattractant protein 1 (MCP-1) and interleukin 1β (IL-1β) in a dose-dependent manner under 0.01% to 0.125% concentration. On the inflammatory model of 3D reconstructed skin induced by H2O2, VGP significantly improved the cell viability and skin structure, and reduced the production of interleukin 8 (IL-8), PGE-2, and leukotriene B4 (LTB4). During 4 week’s treatment with test shampoo containing 0.5% VGP thrice a week on 16 subjects met with different symptoms, VGP reduced the sebum content and TEWL, improved the redness, itching and dandruff on human scalp skin. Therefore, as a natural active ingredient VGP can play a role in scalp care and skin care by targeting inflammation. Note de contenu : - MATERIALS AND METHODS : VGP preparation - Maintenance of cels - Anti-inflammatory experiments on cells - Anti-inflammatory experiments on 3D reconstructed skin - Scalp care test in vivo - Statistical analysis - RESULTS : Anti-inflammatory efficacy of VGP against M. furfur on cells - VGP inhibited the inflammation and cell damage on reconstructed skin - VGP reduced the itching and redness of human scalp skin - Table 1 : Effect of VGP on the viability of two cells - Table 2 : The effect of VGP on scalp redness, dandruff and itching En ligne : https://drive.google.com/file/d/1nlf8RoLehtbFeYtKSvSnZ-81El45gOIT/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=36118 [article]

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