| Titre : |
Collagenases and their inhibitors : a review |
| Type de document : |
texte imprimé |
| Auteurs : |
Sijin Wu, Auteur ; Xuewei Zhou, Auteur ; Zhicheng Jin, Auteur ; Haiming Cheng, Auteur |
| Année de publication : |
2023 |
| Article en page(s) : |
20 p. |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antienzymes
CollagénasesLes collagénases sont des enzymes capables de rompre les liaisons peptidiques du collagène. Elles facilitent la destruction des structures extracellulaires lors de la pathogenèse bactérienne. Ce sont des exotoxines.
La production de collagénases peut être induite lors d'une réponse immunitaire, par les cytokines qui stimulent les cellules telles que les fibroblastes et les ostéoplastes et occasionnent indirectement des lésions tissulaires.
Cuirs et peaux
Enzymes microbiennes
Epilage enzymatique
Métalloprotéinases
|
| Index. décimale : |
675 Technologie du cuir et de la fourrure |
| Résumé : |
Hide and skin are complex tissue where the most abundant component is collagen. Matrix metalloproteinases and bacterial collagenases are two kinds of collagenases that can cleave the triple-helical domain of native fibrillar collagens. In this paper, the family members and domain composition of matrix metalloproteinases and bacterial collagenases are summarized. The catalytic mechanism of collagen hydrolysis by collagenases is described, and the methods adopted to date for investigating and regulating collagenases and their inhibitors are reviewed. Furthermore, the applications of collagenases and their inhibitors in biomedicine, food processing and the enzymatic unhairing process in the leather-making industry are presented. |
| Note de contenu : |
- PROGRESS OF RESEARCH ON COLLAGENASES : research on collagenases - MMPs - Bacterial collagenases - Applications of collagenases
- REGULATORY APPROACHES USING COLLAGENASE INHIBITORS : Zinc-binding inhibitors - Non zinc-binding inhibitors - Applications of collagenase inhibitors
- Table 1 : Classification of MMP family with their domain organization and substrates preference
- Table 2 : Applications of collagenases in the biomedical field
- Table 3 : List of inhibitors with different inhibitory principles
- Table 4 : List of MMP-13 inhibitors for the treatment of OA
- Table 5 : List of bacterial collagenases (ColH) inhibitors |
| DOI : |
https://doi.org/10.1186/s42825-023-00126-6 |
| En ligne : |
https://link.springer.com/content/pdf/10.1186/s42825-023-00126-6.pdf |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=40069 |
in COLLAGEN AND LEATHER > Vol. 5 (2023) . - 20 p.
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Collagenases and their inhibitors : a review in COLLAGEN AND LEATHER, Vol. 5 (2023)
