Biotechnologically produced moss active improves skin resilience / Franziska Wandrey in SOFW JOURNAL, Vol. 144, N° 9 (09/2018)  

[article]  inSOFW JOURNAL > Vol. 144, N° 9 (09/2018) . - p. 34-38 Titre : Biotechnologically produced moss active improves skin resilience Type de document : texte imprimé Auteurs : Franziska Wandrey, Auteur ; Bernhard Henes, Auteur ; Fred Zülli ; Ralf Reski Année de publication : 2018 Article en page(s) : p. 34-38 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge Biomolécules actives Cosmétiques Hydratation Peau -- Soins et hygiène Produits hydratants Index. décimale : 668.5 Parfums et cosmétiques Résumé : Mosses substantially helped changing primitive earth into a green planet before vascular plants even existed. They encode genes and proteins for extraordinary resilience long abandoned by higher plants. Biotechnology offers a sterile production of the moss Physcomitrella patens in a reproducible and sustainable way. MossCellTecTm No. 1 is the first biotechnological moss-based product for cosmetic application. In our research, we have investigated the importance of cell nucleus health as a novel target for anti-aging cosmetics. Interestingly, the moss extract was able to improve the expression of cell nucleus health markers in aged skin cells. Additionally, the active ingredient could improve the hot-humid/cold-dry adaptation of reconstructed skin and improved skin homôgeneity, barrier and hydration despite stressful weather conditions in a placebo-controlled clinicat study. The moss acItive may therefore enhance the general resilience of the skin against environmental changes. Note de contenu : - INTRODUCTION : Moss produced by biotechnology - Cell nucleus health, a novel anti-aging concept - MATERIALS AND METHODS : Gene expression in old vs. young keratinocytes - Temperature and humidity adaptation of 3D skin model - Skin adaptation in a clinical study - RESULTS AND DISCUSSION : P. patens extract improves cell nucleus health in aged skin cells - Improved skin adaptation to environmental changes En ligne : https://drive.google.com/file/d/1keHgHUnCCzRiVne4B_bexmF761ej5Ao5/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=30957 [article]

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Improved cell nucleus health with moss cell technology / Franziska Wandrey in PERSONAL CARE EUROPE, Vol. 12, N° 2 (04/2018)  

[article]  inPERSONAL CARE EUROPE > Vol. 12, N° 2 (04/2018) . - p. 131-134 Titre : Improved cell nucleus health with moss cell technology Type de document : texte imprimé Auteurs : Franziska Wandrey, Auteur ; Daniel Schmid, Auteur ; Bernhard Henes, Auteur ; Fred Zülli, Auteur Année de publication : 2018 Article en page(s) : p. 131-134 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge Biotechnologie Cellules végétales Cosmétiques Extraits de plantes:Extraits (pharmacie) Hydratation Mousses (plantes) Peau -- Soins et hygiène Perte insensible en eau Index. décimale : 668.5 Parfums et cosmétiques Résumé : Mosses were among the first plants that conquered the land and they used their extraordinary adaptation abilities to survive from the prehistoric age until the present day. To harvest the resilient properties of moss, an innovative moss cell technology was used to grow moss cells as a culture in the lab. Latest research has shown triat the moss active contributes to 'cell nucleus health', a novel anti-ageing concept. The cell nucleus does not only contain the cell's DNA but is also involved in regulating important cellular processes. Efficient transport of molecules into and out of the cell nucleus is crucial for adapting to the ever-changing environment. In vitro studies have shown that the moss extract improves expression of cell nucleus health markers in aged cells and helps skin adapt to climatic changes. In a placebo controlled clinical study with women that are exposed to daily temperature changes in the summer, the moss active significantly improved skin hydration, barrier and homogeneity after just two weeks for a more resilient skin. Note de contenu : - Mosses : the first plants on earth - Biotechnology to grow moss in the lab - Materials and methods : Gene expression in old vs. young keratinocytes - Temperature and humidity adaptation of 3D skin model - Skin adaptation in a clinical study - Results and discussion : Moss extract improves cell nucleus health in aged skin cells - FIGURES : 1. Schematic illustration of the components of the cell nucleus - 2. Gene expression of cell nucelus health markers in keratinocytes from a young donor and an ol donor treated with Physcomitrella patens extract - 3. Adaptation of 3D skin models treated with the moss active to climatic changes - 4. Expression of the stress marker LCE1A in 3D skin models determined with immunofluorescence and image analysis - 5. Improvement of skin hydration with the moss active - 6. Improvement of TEWL with the moss active - 7. Improvement of skin tone homogeneity with the moss active - 8. Visible improvement of skin tone with the moss active En ligne : https://drive.google.com/file/d/1ESPk9qQdm_ZotIYuKkGMk5GSu8l7rW2B/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=30463 [article]

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A Swiss glacier bacterium to vitalize tired skin / Christina Pickel in SOFW JOURNAL, Vol. 146, N° 3 (03/2020)  

[article]  inSOFW JOURNAL > Vol. 146, N° 3 (03/2020) . - p. 2-7 Titre : A Swiss glacier bacterium to vitalize tired skin Type de document : texte imprimé Auteurs : Christina Pickel, Auteur ; Franziska Wandrey, Auteur ; Daniel Schmid, Auteur ; Bernhard Henes, Auteur ; Fred Zülli, Auteur Année de publication : 2020 Article en page(s) : p. 2-7 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Actifs anti-fatigue (cosmétique) Antiâge:Antirides Bactéries Cosmétiques Dermo-cosmétologie Extraits de plantes:Extraits (pharmacie) Fibroblastes Molécules chaperonnes Peau -- Soins et hygiène Index. décimale : 668.5 Parfums et cosmétiques Résumé : Today’s society is characterized by demanding jobs, long working hours and an increasingly hectic lifestyle, which frequently results in a lack of sleep. This is often markedly reflected of the skin by a tired appearance of the face. Recent research showed that also on the molecular level, lack of sleep causes stress and leads to premature aging. A major stress mechanism, the unfolded protein response (UPR) of the endoplasmic reticulum (ER), gets compromised by sleep deprivation, leading to the accumulation of misfolded proteins which damage the cell. To target this novel cellular aging mechanism, an extract of the psychrotolerant Swiss glacier bacterium Iodobacter ssp. was developed and analyzed for its efficacy to reduce ER stress and visible signs of tiredness. Treatment of aged fibroblasts with the extract led to an increase in the expression of ER chaperones which mediate the UPR and energized cells through an increase of ATP levels in a cellular model of sleep deprivation. Placebo-controlled randomized clinical studies conducted with sleep-deprived and overworked volunteers demonstrated that treatment with the Iodobacter-derived active ingredient IceAwakeâ„¢ improved several skin parameters associated with skin aging, leading to a vitalized and rejuvenated appearance. Note de contenu : - INTRODUCTION : Lack of sleep impacts on the cellular stress response - Harnessing the potential of extremophile organisms - A freshness kick for tired skin with a swiss glacier bacterium - METHODS AND RESULTS : Iodobacter ssp. extract re-activates chaperone expression in aged fibroblasts - ER stress is reduced by iodobacter ssp. extract in a cellular model of sleep deprivation - IceAwakeTM ameliorate visible signs of tiredness in mixed study population - Fig. 1 : Gene expression of chaperone genes in aged fibroblasts treated with Iodobacter ssp. extract relative to untreated cells - Fig. 2 : ATP levels in AD fibroblasts upon treatment with Iodobacter ssp. extract relative to untreated cells - Fig. 3 : Quantification of MAM contact points in healthy cells or AD fibroblasts treated with the Iodobacter active or left untreated - Fig. 4 : Immunofluorescence staining of MAM contact points in healthy cells or AD fibroblasts treated with the Iodobacter active or left untreated - Fig. 5 : Decrease of wrinkle depth upon treatment with IceAwakeâ„¢ - Fig. 6 : Reduction of tired appearance upon treatment with IceAwakeâ„¢ - Fig. 7 : Visible improvement of wrinkle depth and dark circles with IceAwakeâ„¢ - Fig. 8 : Increase in radiance with IceAwakeâ„¢ En ligne : https://drive.google.com/file/d/1loBLI9V-EftSW37JaxNslSg-kvYiOCzi/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33820 [article]

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