Stimulating Nrf2 and inhibiting NF-kB to help skin combating pollution / E. Bony in SOFW JOURNAL, Vol. 144, N° 3 (03/2018)  

[article]  inSOFW JOURNAL > Vol. 144, N° 3 (03/2018) . - p. 16-22 Titre : Stimulating Nrf2 and inhibiting NF-kB to help skin combating pollution Type de document : texte imprimé Auteurs : E. Bony, Auteur ; I. Renimel-Krolkiewicz, Auteur ; Jean-Yves Berthon, Auteur ; C. Leduc, Auteur ; Philippe Bedos, Auteur ; P. Schlegel, Auteur Année de publication : 2018 Article en page(s) : p. 16-22 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Actifs anti-pollution Cosmétiques Peau -- Effets de la pollution atmosphérique Peau -- Soins et hygiène Index. décimale : 668.5 Parfums et cosmétiques Résumé : The skin is routinely exposed to stresses from environmental pollution. These repeated and regular exposures can profoundly affect skin physiology, and may lead to irreversibie consequences. We studied the potential of a Schisandra chinensis (S.C.) extract, particularly ennched in lignans, to enhance skin defense mechanisms involved in pollution stress response, with the main pathways involved in skin being Nuclear Factor Kappa B (NF-kB), DJ-1, the nuclear factor erythroid 2-related factor 2 (Nrf2) and aryl hydrocarbon receptor (AhR) signaling pathways. Using an in vitro model, we showed that co-treatment with Urban dust and S.C. extract was able to stimulate the expression of Nrf2 and DJ-1, as well as the decrease of NF-kB and AhR, suggesting that this active extract may provide wide protection for skin against daily environmental insults. In a skin equivalent model stressed by Urban dust, the extract provided a global protection of skin components as shown by key proteins involved in the epidermal barrier. Even if further investigations are needed, we speculate that S.C. extract can be used to butter the harmful effects.of free radicals and enhance the skin barrier,due to air pollutant interactions with the skin, allowing a global preservation of cutaneous structures. Note de contenu : - Fig. 1. Summarizes the molecular mechanisms for pollutant-induced ROS generation and pro-inflammatory cytokines such as IL-1α, IL-8, and TNF-α, resulting i increased skin aging. Mitogen-activated protein kinases (MAPK) ; NF-KB : nuclear factor KB ; AP-A : activator protein-1 ; PI3K : phosphoinositide 3-kinase - Fig. 2. Polycyclic aromatic hydrocarbons (PAHs) and particulate matter (PM) induce ROS generation and pro-inflammatory cytokines. Upon ligation by PAHs and PM, the activated AhR translocates form the cytoplasm into the nucleus. This translocated AhR binds with ANRT, resulting in the activation of cytochrome P450, family 1, member A1 (CYP1A1) transcription. ROS generated by CYP1A1 stimulates the production of TNF-α and IL-8 - Fig. 3. NK-KB cytoplasm expression after Urban dust exposure or co-treatment with Urban dust and S.C. extract ***p<0.001 versus Urban dust - Fig. 4. AhR cytoplasm expression after Urban dust exposure or co-treatment with Urban dust and S.C. extract ***p<0.001 versus Urban dust - Fig. 5. NrF2 cytoplasm expression after Urban dust exposure or co-treatment with Urbandust and S.C. extrct - Fig. 6. DJ-1 expression after Urban dust exposure or co-treatment with Urban dust and S.C. extract ***p<0.001 versus Urban dust - Fig. 7. Secretion of PGE2 and il-6 in polluted or non-reconstructed skin supernatant treated or not with S.C. extract. Analysis has been done 24h after pollutant stress. ***p<0.001 versus Urban dust - 8. MDA expression in epidermis of skin equivalent model. Analysis has been done 24h after pollutant stress En ligne : https://drive.google.com/file/d/1YZRvsU-82xTpVPt-JfmooGJlU2VaVl8w/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=30351 [article]

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