A new delivery strategy to create effective cosmetics / Eva Rodriguez Hortelano in PERSONAL CARE EUROPE, Vol. 11, N° 4 (09/2017)  

[article]  inPERSONAL CARE EUROPE > Vol. 11, N° 4 (09/2017) . - p. 18-20 Titre : A new delivery strategy to create effective cosmetics Type de document : texte imprimé Auteurs : Eva Rodriguez Hortelano, Auteur ; Alfredo Brisac Canales, Auteur ; Marc Prieto, Auteur ; Aina Arbos, Auteur ; Maria Alonso Sande, Auteur Année de publication : 2017 Article en page(s) : p. 18-20 Langues : Anglais (eng) Catégories : Dermo-cosmétologie Diffusion (physique) Emulsions -- Emploi en cosmétologie Ingrédients cosmétiques Liposomes Nanoémulsions Nanotechnologie Peau -- Soins et hygiène Index. décimale : 668.5 Parfums et cosmétiques Résumé : Presently, a significant array of cosmetic ingredients fail to exercise their intended action because they are not able to pass through the stratum corneum and epidermis. A good example may be the use of ingredients designed to promote collagen generation by fibroblasts that never act as expected, since they are not able to reach the dermis where fibroblasts are located. Hence, the in vitro testing results never become a reality. In the search of new levels of efficacy, to bring ingredients under the stratum corneum has always been a necessity in dermocosmetology, to reach the deep layers of the skin without the need for injectables and avoid the risk of becoming systemic, suitable for the cosmetic industry. BioDan's thorough knowledge of skin generation, epithelial modelling and 3D bioprinted skin has allowed the development of a new generation of nanocarriers capable of delivering ingredients without the need for injectables deep into the skin's dermis and epidermis, trespassing the stratum corneum, and capable of modulating their penetration capabilities. The new nanocarriers are at least twice as deformable as previous technologies, built with 100% vegetable structures, 100% clean and made with no use of parabens, synthetic chemicals and non-covalent technologies. Extremely biocompatible and biodegradable, Biodan's nanotechnological platform is made of GRAS-listed or organic naturel compounds and tailored with a customised composition to the needs of each individual ingredient. Biodan's new nanostructures are based on the use of new ultradeformable design principles on traditional architectures, such as nanoparticles, micelles, nanocapsules, nanoemulsions or liposomes. In the present study, we will present how two different nanostructures, presenting identical mass compositions and both capable of preserving the integral qualities of active ingredients, bath significantly differ in their behaviour, such as physicochemical properties, toxicity, permeation and delivery. Note de contenu : - Question of structure - Characterisation matters - Toxicity / cell viability in vitro - Vesicle transport and internalisation in vitro - TABLES : 1. Physicochemical characterisation - 2. Deformation ability ratios of the different structures - 3. Transport measurements. Measurement of the fluorimetry of the vesicles present of the culture medium of the BioDan model skin - FIGURES : 1. Transmission Electronic Microscopy micrograph showing the liposome and nanoemulsion morphology - 2. Cell viability of LPs and NEs structures - 3. Transport assay diagram - 4. Graphical disposition of data shown in table 2 - 5. Cell monolayer observed by fluorescence microscopy - 6. Measurement of the fluorescent vesicles present in the monolayer En ligne : https://drive.google.com/file/d/169Had9NtgEcdXPMxIL0jEFWhZIW9XcQG/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=29306 [article]

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