| Titre : |
SYN-UPâ„¢ bolsters the skin's resilience against environmental stressors |
| Type de document : |
texte imprimé |
| Auteurs : |
Remo Campiche, Auteur ; Peter Wikström, Auteur ; Dominik Imfeld, Auteur ; Volker Rosenberger, Auteur |
| Année de publication : |
2017 |
| Article en page(s) : |
p. 6-12 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Anti-inflammatoires
Biomolécules actives
Peau -- Soins et hygiène
Sécheresse cutanéeUne xérose est un dessèchement de la peau.
Elle peut avoir différentes causes, comme certaines pathologies (dermatite atopique aussi appelé eczéma atopique), des carences, notamment en Vitamine A, ou des facteurs externes, comme les contacts avec des substances irritantes ou le traitement par certains médicaments.
Stress oxydatif
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Dry skin conditions are among consumers' most pressing concerns. These can be caused by decreased skin barrier function resulting from environmental factors. A strong skin barrier with high resilience is required to combat negative environmental influences like UV irradiation, air pollution or dry and cold climate conditions. These can lead to cutaneous inflammatory reactions. We recently demonstrated that plasmin activity was increased on sun-exposed facial stratum corneum. We also showed that the activities of proteases belonging to the plasminogen system, namely plasmin and urokinase, are elevated in facial stratum corneum and correlate with transepidermal water loss (TEWL) , which leads to a weakened skin barrier and dry skin.
In order to help reduce dry skin caused by harsh environmental conditions we developed SYN-UP™ — a peptide-based specific dual inhibitor of urokinase and plasmin (INCI : Benzylsulfone-SerylHornophenylalanine Amidinobenzamide Acetate). It suppresses inflammatory reactions in vitro and strengthens the skin's barrier by improving cornified envelope maturation and normalizing desquamation.
In a 28-day placebo-controlled human study we showed that SYN-UPâ„¢ was able to boost skin resilience and to lower TEWL. The skin condition improved, resisting the detrimental effects of persistent negative environmental influences mimicked by consecutive facial tape strippings. Moreover, expert grading and a self-assessment questionnaire showed that the skin was smoother and more hydrated. |
| Note de contenu : |
- Inhibition of urokinase and plasmin by SYN-UPâ„¢ in keratinocytes in vitro
- Analysis of the down-stream targets of plasmin in vitro
Decreased TEWL and increased skin resilience in vivo
- Enhanced skin smoothness and skin hydration
- Decreased stinging perception after inhibition treatment
- Attractive, great looking skin |
| En ligne : |
https://drive.google.com/file/d/1ekF0Mr_iaa9YjMcoBQWok_xJ4MqhIchi/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=28540 |
in SOFW JOURNAL > Vol. 143, N° 4 (04/2017) . - p. 6-12
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