The rational design of biomimetic skin barrier lipid formulations using biophysical methods / P. A. Bulsara in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 39, N° 2 (04/2017)

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 39, N° 2 (04/2017) . - p. 206-216 Titre : The rational design of biomimetic skin barrier lipid formulations using biophysical methods Type de document : texte imprimé Auteurs : P. A. Bulsara, Auteur ; P. Varlashkin, Auteur ; J. Dickens, Auteur ; David J. Moore, Auteur ; Anthony Vincent Rawlings, Auteur ; M. J. Clarke, Auteur Année de publication : 2017 Article en page(s) : p. 206-216 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Barrière cutanée Chimie biomimétique Diffractométrie de rayons X Emulsions -- Emploi en cosmétologie Fourier, Spectroscopie infrarouge à transformée de Peau -- Physiologie Index. décimale : 668.5 Parfums et cosmétiques Résumé : The focus of this communication was to study phospholipid-structured emulsions whose phase behaviour is modified with monoalkyl fatty amphiphiles. Ideally, these systems would mimic key physical and structural attributes observed in human stratum corneum (SC) so that they better alleviate xerotic skin conditions. Phosphatidylcholine-structured emulsions were prepared, and their phase behaviour modified with monoalkyl fatty amphiphiles. The effect of molecular volume, acyl chain length and head-group interactions was studied using a combination of physical methods. Water vapour transmission rate (WVTR) was used as a primary test to assess occlusive character. Changes in the vibrational modes observed in Fourier transform infrared (FTIR) spectroscopy and bilayer spacing measured by X-ray diffraction (XRD) were then applied to elucidate the lateral and lamellar microstructural characteristics in the systems. Water vapour transmission rate demonstrated that as the phosphatidylcholine acyl chain length increased from C14, to C18, to C22, there was a corresponding increase in occlusive character. The addition of monoalkyl fatty amphiphiles such as behenic acid, behenyl alcohol or cetostearyl alcohol to a base formulation incorporating dipalmitoyl and distearoylphosphatidylcholine (C18) was seen to further increase barrier characteristics of the emulsions. FTIR methods used to probe lipid-chain conformational ordering demonstrated that as phosphatidylcholine acyl chain lengths increased, there was a corresponding improvement in acyl chain ordering, with an increase in thermal transition temperatures. The addition of a monoalkyl fatty amphiphile resulted in conformational order and thermal transition temperature improvements trending towards those observed in stratum corneum. FTIR also demonstrated that systems containing behenic acid or behenyl alcohol exhibited features associated with orthorhombic character. X-ray diffraction data showed that addition of monoalkyl fatty amphiphile also resulted in thicker lamellar structures than when those agents are not present. The generalized approach described herein is shown to mechanistically describe the occlusive character of phospholipid-structured formulations in the presence of long-chain fatty acids or alcohols and that they exhibit characteristics mimicking those found in human SC lipids. Note de contenu : - MATERIALS AND METHODS : Formulation of occlusive agents in a simplified emulsion vehicle - Water vapour transmission rate methodology - FTIR methodology - XRD methodology - Statistic - RESULTS : WVTR results - FTIR results - SAXS analysis DOI : 10.1111/ics.12366 Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=28251 [article]

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