| Titre : |
Edelweiss helps to protect against glycation-related skin ageing |
| Type de document : |
texte imprimé |
| Auteurs : |
François Paul, Auteur ; Dominik Imfeld, Auteur |
| Année de publication : |
2021 |
| Article en page(s) : |
p. 14-19 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge
Biomolécules actives
Dermo-cosmétologie
Détoxication métabolique d'une substance
Edelweiss et constituants
Glycation
Ingrédients cosmétiques
Peau -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
Glycation-induced, Advanced Glycation End Products (AGEs) make a significant contribution to signs of skin ageing. In the pro-ageing skin care market, cosmetic antioxidants are often exploited for their ability to protect against free radicals and oxidative stress, but some of these ingredients also have potential to reduce or prevent the effects of glycation. DSM has conducted two new studies to explore the anti-glycation potential in a bioactive with proven antioxidant properties, ALPAFLOR® EDELWEISS CB [INCI Leontopodium alpinum extract] an extract of organically grown and ethically sourced Edelweiss plants. The first study demonstrated the ingredient’s ability to down-regulate accumulation of AGEs by up to 55% in skin cells in vitro and to activate the detoxifying enzyme named Gloxalase-1 (Glo-1), which plays a key role in protecting keratinocyte proteins against oxidative damage during skin ageing, by 65%. The second study demonstrated that the bioactive inhibited Collagen Type IV glycation by 67%. |
| Note de contenu : |
- Antioxidants in pro-ageing skincare - a burgeoning market
- Glycation, AGEs, and their impact on skin
- Could antioxidants counteract the effects of AGEs ?
- Study 1 : in vitro assessment of Leontopodium alpinum extract's anti-glycation potential in human keratinocytes (NHEK) - In vitro cell cultures - Anti-glycation potential - 1) Intracellular accumulation of CMLs - 2) Filaggrin expression - 3) Glyoxalase 1 activity
- Study 2 : Assessment of the modulating effect of Leontopodium alpinum extract on Collagen Type IV Glycation
- Conclusions : Study 1 - Study 2 - Overall conclusion
- About the active |
| En ligne : |
https://drive.google.com/file/d/12wIJFWuR47Tzcl-BlI66HB-t0Kfx-F3p/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=36328 |
in SOFW JOURNAL > Vol. 147, N° 9 (09/2021) . - p. 14-19
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Edelweiss helps to protect against glycation-related skin ageing in SOFW JOURNAL, Vol. 147, N° 9 (09/2021)
