| Titre : |
Water-in-oil microemulsions composed of monoolein enhanced the transdermal delivery of nicotinamide |
| Type de document : |
document électronique |
| Auteurs : |
Momoko Kitaoka, Auteur ; Trung Cong Nguyen, Auteur ; Masahiro Goto, Auteur |
| Année de publication : |
2021 |
| Article en page(s) : |
p. 302-310 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Absorption cutanée
Barrière cutanée
Caractérisation
Dermo-cosmétologie
Formulation (Génie chimique)
Microémulsions
Nicotinamide
Peau -- Anatomie
Peau -- Physiologie
Peau -- Soins et hygiène
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : Nicotinamide, also known as niacinamide, is a water-soluble vitamin that is used to prevent and treat acne and pellagra. It is often found in water-based skin care cosmetics because of its high water solubility. Nicotinamide is a small molecule with a molar mass of 122.1 g/mol. However, it has a hydrophilic nature that becomes an obstacle when it penetrates through the skin. The topmost layer of the skin, the stratum corneum, acts as a strong hydrophobic barrier for such hydrophilic molecules. The oil-based formulations are expected to enhance the transdermal delivery efficiency of nicotinamide.
- Methods : We have developed oil-based microemulsion formulations composed of a squalane vehicle. Monoolein was used as an emulsifier that has a potential to enhance the nicotinamide delivery through the stratum corneum.
- Results : Because the mean size of the emulsions measured by dynamic light scattering was 20.9 ± 0.4 nm, the microemulsion formulation was stable under the long-term storage. Monoolein acted as a skin penetration enhancer, and it effectively enabled the penetration of nicotinamide through human abdominal skin, compared with nicotinamide in a phosphate-buffered saline solution. The flux was increased 25-fold. Microscopic imaging revealed that the hydrophilic bioactive compounds penetrated through the intercellular spaces in the epidermis.
- Conclusion : The monoolein-based microemulsion was transparent and stable, suggesting that it is a promising formulation for a transdermal nicotinamide delivery.
|
| Note de contenu : |
- MATERIALS AND METHODS : Materials - Preparation of microemulsions carrying nicotinamide - Particle size analysis - Reversed-phase high-performance liquid chromatography (HPLC) - Nicotinamide release test from the microemulsion formulation - In vitro skin penetration experiment - Fluorescence confocal laser scanning microscopy
- RESULTS AND DISCUSSION : Preparation and characteristics of microemulsions - In vitro penetration of nicotinamide - Histology analysis
- Table 1 : Compositions of 1 mL of the water-in-oil microemulsion formulations containing nicotinamide (5 mg/mL)
- Table 2 : Particle z-average and polydispersity index (PDI) of the microemulsions as measured through dynamic light scattering
- Table 3 : Skin penetration parameters of nicotinamide from a microemulsion formulation and PBS |
| DOI : |
https://doi.org/10.1111/ics.12695 |
| En ligne : |
https://drive.google.com/file/d/1S_tMLxYvVTqhDv2nBvZ_b9VETyVgpjaL/view?usp=shari [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35897 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° 3 (06/2021) . - p. 302-310
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Water-in-oil microemulsions composed of monoolein enhanced the transdermal delivery of nicotinamide in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° 3 (06/2021)
