| Titre : |
Design of leather footwear for diabetics containing chlorhexidine digluconate microparticles |
| Type de document : |
texte imprimé |
| Auteurs : |
Fatih Yalcin, Auteur ; Huseyin Ata Karavana, Auteur ; Seda Rencber, Auteur ; Sinem Yaprak Karavana, Auteur |
| Année de publication : |
2020 |
| Article en page(s) : |
p. 79-86 |
| Note générale : |
Bibliogr. |
| Langues : |
Américain (ame) |
| Catégories : |
Antiseptiques
Caractérisation
Chaussures -- Conception et construction
Cuir
Diabète
Digluconate de chlorhexidine
Encapsulation
Ethylcellulose
Formulation (Génie chimique)
Matériaux -- Imprégnation
Microbiologie
Particules (matières)
Pieds -- Soins et hygiène
Système de libération contrôlée (technologie)
|
| Index. décimale : |
675 Technologie du cuir et de la fourrure |
| Résumé : |
ChlorHexidine Digluconate [CHD] was encapsulated inside an ethylcellulose shell material [Aquacoat ECD], and then spray dried to produce mixed microparticles (MPs). The validity and functional quality of the resultant [CHD-MPs] were analyzed on vamp and lining leather which are used to manufacture shoes for diabetics. The morphology, efficiency of encapsulation and in vitro release characteristics of the [CHD-MPs] were optimized in order to impregnate [CHD-MPs] onto leather footwear for diabetics. Scanning electron microscopy (SEM) was used to characterize the [CHD-MPs] and the leathers treated with it. SEM images illustrated that the [CHD-MPs] were spherical, smooth in shape and adhered well to leather. In vitro CHD-release studies from its MPs, and for leather treated with it were performed in phosphate buffer saline at pH =7.2. There was an inherently controlled release behaviour of CHD for all the formulations on leather. Finally, microbiologic studies on leather treated with [CHD-MPs] were done. This study suggested that footwear containing [CHD- MPs] is/will improve the quality of daily life for diabetics. |
| Note de contenu : |
- EXPERIMENTAL : Materials
- METHODS : Prepration of MPs - Particle morphology of the MPs - Conditions of Ultra-Performance Liquid Chromatography (UPLC) - Encapsulation efficiency of the MPs - FT-IR analysis - In vitro drug release of the MPs - Application of the MPs on the leathers - Scanning Electron Microscopy (SEM) of the leathers with the MPs - In vitro drug release of the leathers with MPs - Microbiologic studies on leathers with MPs
- RESULTS AND DISCUSSION : Particle morphology - UPLC conditions - Encapsulation efficiency - Fourier Transform Infrared Spectroscopy (FT-IR) - In vitro drug release of the MPs - SEM of the leathers with the MPs - In vitro drug release of the leathers impregnated with MPs - Microbiologic studies on leathers with MPs |
| DOI : |
https://doi.org/10.34314/jalca.v115i03.1625 |
| En ligne : |
https://drive.google.com/file/d/1bMgMmBeb608l3LTX7OTST1S0mMdLW9-K/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=33885 |
in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA) > Vol. CXV, N° 3 (03/2020) . - p. 79-86
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Design of leather footwear for diabetics containing chlorhexidine digluconate microparticles in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA), Vol. CXV, N° 3 (03/2020)
