Investigation on release of highly water soluble drug from matrix-coated pellets prepared by extrusion–spheronization technique / Muhammad Iqbal Nasiri in JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH, Vol. 13, N° 2 (03/2016)  

[article]  inJOURNAL OF COATINGS TECHNOLOGY AND RESEARCH > Vol. 13, N° 2 (03/2016) . - p. 333-344 Titre : Investigation on release of highly water soluble drug from matrix-coated pellets prepared by extrusion–spheronization technique Type de document : texte imprimé Auteurs : Muhammad Iqbal Nasiri, Auteur ; Rabia Ismail Yousuf, Auteur ; Muhammad Harris Shoaib, Auteur ; Muhammad Fayyaz, Auteur ; Faaiza Qazi, Auteur ; Kamran Ahmed, Auteur Année de publication : 2016 Article en page(s) : p. 333-344 Note générale : Bibliogr. Langues : Américain (ame) Catégories : Cellulose La cellulose est un glucide constitué d'une chaîne linéaire de molécules de D-Glucose (entre 200 et 14 000) et principal constituant des végétaux et en particulier de la paroi de leurs cellules. Diffusion (physique) Enrobage pharmaceutique Ethylcellulose Extrusion sphéronisation Hydroxypropyl méthylcellulose Médicaments Polymères cristallins Polymères en médecine Index. décimale : 667.9 Revêtements et enduits Résumé : The objective was to formulate itopride HCl (ITP) extended release matrix-coated pellets by extrusion–spheronization and to investigate the influence of concentration and viscosity grade of different polymers on release of a highly water soluble drug. The matrix pellet formulations consisted of polymers (10–30%) like hydroxypropyl methylcellulose (HPMC K4M, K15M, and K100M), ethyl cellulose (EC-7 cps), microcrystalline cellulose (10–30%) and a fixed quantity of lactose (10%). The initial fast drug release from the matrix pellets was effectively controlled by coating with 5% ethyl cellulose (10 cps) dispersion. The dissolution studies of coated formulations were carried out at different pH, and data were analyzed for drug release kinetics. Scanning electron microscope was used to examine the surface morphology and cross section of pellets. Kinetics of all coated formulations were best explained by Higuchi model (R 2 = 0.94–0.99). However, HPMC matrix-coated pellets (F1, F4 and F7) also followed Baker and Lonsdale model (R 2 = 0.96–0.99), whereas, EC matrix-coated pellets (F10) followed zero-order kinetics (R 2 = 0.99). Release mechanism of all coated formulations was non-fickian. Both uncoated and coated pellets were found to be spherical. Fourier transform infrared spectroscopy was conducted on the coated formulations and no drug–excipients interaction was found. Note de contenu : - Physical and chemical evaluation of uncoated ITP matrix pellet formulation - Image analysis - Scanning electron microscopy (SEM) - Fourier transform infrared spectroscopy (FTIR) - In vitro drug release studies - Drug release kinetics - Drug release mechanism - Stability studies DOI : 10.1007/s11998-015-9749-1 En ligne : https://link.springer.com/content/pdf/10.1007%2Fs11998-015-9749-1.pdf Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=26118 [article]

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