| Titre : |
Peptide inspired by sea anemone venom comforts sensitive skin |
| Type de document : |
texte imprimé |
| Auteurs : |
Franziska Wandrey, Auteur ; Daniel Schmid, Auteur ; Fred Zülli, Auteur |
| Année de publication : |
2018 |
| Article en page(s) : |
p. 20-24 |
| Langues : |
Anglais (eng) |
| Catégories : |
Biomolécules actives
Etude in vivo
Neurocosmétique
Peau -- Soins et hygiène
Peptides
Sensibilité cutanée
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
A novel neurocosmetic soothing active, a biomimetic peptide inspired by the analgesic component of sea anemone venom, immediately comforts sensitive skin after the first application. An in vitro assay showed that the peptide reduced the ac¬tivation of the TRPV1 pain receptor. To ensure improved skin uptake, the peptide was incorporated into a soft sphere carrier system based on shea butter. In clinical studies, the soothing active increased the electrical current perception threshold of the skin, which is an indicator for reduced skin reactivity and decreased skin sensitivity by reducing the response to skin irritation. |
| Note de contenu : |
- INTRODUCTION : Environmental factors lead to uncomfortable skin - The molecular cause of sensitive skin - A solution for sensitive skin derived from sea anemone venom
- MATERIALS AND METHODS : Whole-cell patch clamp technique - Current perception threshold measurements - Lactic acid stinging test
- RESULTS AND DISCUSSION : Peptide derived from sea anemone inhibits TRPV1 - Single treatment with the soothing active reduces skin reactivit - Reduction of skin sensitivity by the soothing active
- FIGURES : 1.Schematic illustration of the presence of TRPV1 receptors in the skin - 2. Heteractis crispa sea anemone specimen - 3. Schematic illustration of the whole-cell patch clamp technique - 4. Inhibition of TRPV1 receptor activation by the pentapeptide - 5. Increase of the CPT after a single application of the soothing active - 6. Reduction of skin sensitivity by the soothing active measured by the lactic acid stinging test |
| En ligne : |
https://drive.google.com/file/d/1bTqGQXa_R2aIeHMVmBtcp2ebEYypuU6b/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=30333 |
in SOFW JOURNAL > Vol. 143, N° 1/2 (01-02/2018) . - p. 20-24
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Peptide inspired by sea anemone venom comforts sensitive skin in SOFW JOURNAL, Vol. 143, N° 1/2 (01-02/2018)
