[article]
| Titre : |
Potential anti-ageing effect of chondroitin sulphate through skin regeneration |
| Type de document : |
document électronique |
| Auteurs : |
D. Min, Auteur ; S. Park, Auteur ; H. Kim, Auteur ; S. H. Lee, Auteur ; Y. Ahn, Auteur ; W. Jung, Auteur ; H.-J. Kim, Auteur ; Y. W. Cho, Auteur |
| Année de publication : |
2020 |
| Article en page(s) : |
p. 520-527 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge
Cicatrisation
Ingrédients cosmétiques
Peau -- Physiologie
Peau -- Soins et hygiène
Peau âgée
Régénération (biologie)
Sulfate de chondroïtine
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : Skin ageing is inevitably exposed through its typical features such as wrinkles and sagging. Therefore, skin anti-ageing is a major issue in cosmetic research to prevent and improve ageing symptoms using effective ingredients. Chondroitin sulphate (CS), a type of glycosaminoglycan, is an important structural component of the extracellular matrix (ECM) and is involved in various biological processes, such as cell proliferation, differentiation and migration. Here, we aimed to investigate the effects of CS on skin regeneration and examine its efficacy as a potential safe and effective skin anti-ageing ingredient.
- Methods : We investigated the effects of CS on cell proliferation in normal human keratinocytes and fibroblasts. Then, cell migration, ECM synthesis and related signalling pathways were examined in fibroblasts through gene and protein expression analysis. Finally, the effect on skin wound healing and regeneration was validated using a full-thickness skin wound model and an aged skin model.
- Results : Chondroitin sulphate treatment increased the proliferation of keratinocytes and fibroblasts. It also stimulated the migration and synthesis of ECM components of fibroblasts. Further analysis revealed that CS induced the expression of type I procollagen by activating the extracellular signal-regulated kinase pathway. Using a full-thickness skin wound model and an aged skin model, we confirmed that CS treatment promoted skin wound healing and regeneration.
- Conclusion : Together, our results indicated that CS has the potential to facilitate skin regeneration, implying that CS could be clinically applied to improve skin ageing. |
| Note de contenu : |
- MATERIALS AND METHODS : Cell culture - Cell proliferation assay - Cell motility assay - Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) - Measurement of type I procollagen synthesis - Western blotting - Wound healing assay using skin wound model and swept-source optical coherence tomography (SS-OCT) imaging - Evaluation of skin regeneration efficacy using an aged skin model - Statistical analysis
- RESULTS AND DISCUSSION : CS enhances the proliferation of keratinocytes and fibroblasts, and facilitates migration of fibroblasts - CS promotes the synthesis of ECM components in fibroblasts - ERK activation by CS contributes to increases in type I procollagen levels in fibroblasts - CS promotes skin wound healing and regeneration in a fullthickness skin wound model - CS promotes epidermal regeneration in the aged skin model |
| DOI : |
https://doi.org/10.1111/ics.12645 |
| En ligne : |
https://drive.google.com/file/d/1BFMCz7i42nJJ8sSCST3Mx-jj8-F3QZ6L/view?usp=shari [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35417 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 42, N° 5 (10/2021) . - p. 520-527
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