La progérine, un nouveau biomarqueur du vieillissement cutané / Estelle Loing in EXPRESSION COSMETIQUE, N° Hors série (12/2012)  

[article]  inEXPRESSION COSMETIQUE > N° Hors série (12/2012) . - p. 335-339 Titre : La progérine, un nouveau biomarqueur du vieillissement cutané Type de document : texte imprimé Auteurs : Estelle Loing, Auteur ; Thierry Suère, Auteur ; Elisabeth Lamarque, Auteur Année de publication : 2012 Article en page(s) : p. 335-339 Note générale : Bibliogr. Langues : Multilingue (mul) Catégories : Antiâge Cellules -- Vieillissement Cosmétiques Etudes cliniques Inhibiteurs (chimie) Peptidases Peptides -- Synthèse Progérine Index. décimale : 668.5 Parfums et cosmétiques Résumé : De récents travaux montrent que la progérine joue un rôle important dans le processus de sénescence cellulaire. En réponse, Progeline TM (INCI : trifluoroacetyl-tripeptide-2), un tripeptide de synthèse, a été développé pour en diminuer sa production, et ainsi réguler les mécanismes biologiques impliqués dans le processus de vieillissement. Note de contenu : - La progérine offre-t-elle des pistes sur le vieillissement normal ou le processus de senescence ? - Accélération ou vieillissement et expression de progérine - Etudes cliniques En ligne : https://drive.google.com/file/d/1ty-0Cyih_7uFAKROyAvzl0FUJYw_MvW_/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=16871 [article]

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Protection of human epidermal cells from UV-induced DNA damage by acetyl hexapeptide-1, a biomimetic peptide analog of α-melanocyte-stimulating hormoneα / Estelle Loing in IFSCC MAGAZINE, Vol. 15, N° 2 (04-05-06/2012)

[article]  inIFSCC MAGAZINE > Vol. 15, N° 2 (04-05-06/2012) . - p. 89-95 Titre : Protection of human epidermal cells from UV-induced DNA damage by acetyl hexapeptide-1, a biomimetic peptide analog of α-melanocyte-stimulating hormoneα Type de document : texte imprimé Auteurs : Estelle Loing, Auteur ; Thierry Suère, Auteur Année de publication : 2012 Article en page(s) : p. 89-95 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : ADN -- Réparation Hexapeptides Protection cutanée Index. décimale : 668.5 Parfums et cosmétiques Résumé : Cutaneous pigmentation by melamins represents the main pathway to protect skin cells against the carcinogenic and ageing effects resulting from UV exposure. α-melanocyte-stimulating hormone (α-MSH) induces epidermal pigmentation upon binding to the melanocortin-1 receptor, which in turn activates the signal transduction pathway taht leads to the induction of tyrosinase and other key players for melanin synthesis. In addition, it has been proven that α-MSH directly reduces UV-induced DNA damage and enhances DNA repair in epidermal melanocytes and keratinocytes by modulating the function of DNA repair molecules. Therefore, there has been increasing interest from skincare companies in developing α-MSH analogs that induce sunless tanning, with a particular emphasis on small peptide analogues for their ability to activate the melanocortin-1 receptor, reduce UV-induced DNA damage and easili penetrate across the stratum corneum after topical application. In this study we demonstrate that acetyl hexapeptide-1, a biomimetic peptide analogue of α-MSH, reduces the genotoxic adverse effects of both UVA and UVB in epidermal melanocytes, and that it protects human epidermal keratinocytes from DNA oxidative damages induced by UVA. Furthemore, using an ex vivo skin model, we show that acetyl hexapeptide-1 significantly reduces the appearance of cyclobutane pyrimidine dimers after UV challenge and that it blocks UV-induced caspase-3 activation and apoptosis. Note de contenu : - EXPERIMENTAL : Cell and tissue culture - Comet assay - Detection of 8-oxo-2'-deoxyguanosine (8-oxo-dG) - Immunohistochemical detection of cyclobutane pyrimidine dimers and caspase-3 - Image quantification by picture analysis - Evaluation of the anti-erythemal properties of acetyl hexapeptide-1 in human volunteers - RESULTS AND DISCUSSION : Acetyl hexapeptide-1 prevents UV-induced genotoxic effects in primary human melanocytes - Acetyl hexapeptide-1 protects human keratinocytes from UVA-induced oxidative damage to DNA - Acetyl hexapeptide-1 protects human skin ex vivo from UV-induced pyrimidine dimers and apoptosis - Anti-erythemal properties of acetyl hexapeptide-1, a clinical study Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=14957 [article]

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Targeting inflammation and pro-resolving mediators with Anetholea anisita extract to improve scalp condition / Romain Duroux in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 44, N° 6 (12/2022)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 44, N° 6 (12/2022) . - p. 614-624 Titre : Targeting inflammation and pro-resolving mediators with Anetholea anisita extract to improve scalp condition Type de document : document électronique Auteurs : Romain Duroux, Auteur ; Vincent Baillif, Auteur ; Fabien Havas, Auteur ; Morgane Farge, Auteur ; Alban Maurin, Auteur ; Thierry Suère, Auteur ; Emeline VanGoethem, Auteur ; Joan Attia, Auteur Année de publication : 2022 Article en page(s) : p. 614-624 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anti-inflammatoires Antioxydants Barrière cutanée Cellules -- Cultures et milieux de culture Cheveux -- Soins et hygiène Cuir chevelu -- Soins et hygiène Extraits de plantes:Extraits (pharmacie) Produits capillaires Index. décimale : 668.5 Parfums et cosmétiques Résumé : - OBJECTIVE : A critical and often-overlooked factor that may give rise to dandruff and oily hair is the intrinsic quality of the scalp stratum corneum (SC), which is often unbalanced and susceptible to external aggressions. Addressing the inflammation element of unhealthy scalp plays an important role in promoting healthy-looking and feeling hair. Although specialized pro-resolving lipid mediators (SPMs) have been studied in the skin to end the inflammation process and promote tissue regeneration, no studies have been provided in the scalp. This study aims to investigate SPMs expression and its role in improving scalp integrity and consequently improving hair appearance using an Anetholea anisita extract. - METHODS : The effect of Anetholea anisita extract was investigated in vitro on human follicle dermal papilla cells (HFDPC), evaluating its antioxidant and anti-inflammatory properties by fluorescence staining and ELISA, respectively. Ex vivo measurement of the volume of human scalp sebaceous glands was performed using X-ray microtomography (micro-CT). The extract was then clinically tested on a population of dandruff sufferers presenting oily hair. Volunteers' sebum was collected on the scalp and analysed by LC–MS/MS or ELISA to identify SPMs and pro-inflammatory markers. Scalp integrity was assessed by measuring the pH and the TEWL. Sebum production, dandruff and hair gloss were also evaluated. - RESULTS : Anetholea anisita extract reduced IL-8 and reactive oxygen species (ROS) generation in HFDPC. Interestingly, this extract also decreased the volume of sebaceous glands as revealed by micro-CT. This result was confirmed in vivo by a decrease in sebum production in volunteers. Moreover, SPMs were analysed and detected in the scalp for the first time. An increase in Lipoxin B4 (LxB4) and Resolvin D1 and D2 (RvD1 and RvD2) was observed after Anetholea anisita treatment as well as decrease in pro-inflammatory sebum mediators expression such as PGE2, LTB4 and IL-8. Consequently, the scalp barrier was reinforced as observed through improved transepidermal water loss (TEWL) and skin surface pH, reducing dandruff and improving hair health. - CONCLUSION : The present results suggest the potential of cosmetic applications of Anetholea anisita extract to improve scalp health by targeting inflammation pathways to decrease dandruff and improve hair condition. Note de contenu : - MATERIALS AND METHODS : Materials - In vitro cell studies - Ex vivo study - Clinical trial - RESULTS : Anetholea anisita extract decreases oxidative stress and inflammation in HFDPC cultures - Anetholea anisita extract decreases the volume of sebaceous glands from scalp - Anetholea anisita extract clinically decreases pro-inflammatory markers and increases SPMs in scalp sebum - Anetholea anisita extract clinically improves scalp condition and decreases dandruff - Table 1 : Clinical trial formulations DOI : https://doi.org/10.1111/ics.12813 En ligne : https://drive.google.com/file/d/1w3tBFMwD4mmgtIGsOpjfcLJw4_DrCVt1/view?usp=share [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38386 [article]

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