| Titre : |
Toxicological testing of cosmetic ingredients using alternative methods - The supplier's perspective |
| Type de document : |
texte imprimé |
| Auteurs : |
Tzutzuy Ramirez, Auteur ; Susanne N. Kolle, Auteur ; Stefan Schulte, Auteur ; Markus Schulz, Auteur ; Annette Mehling, Auteur ; Marcus Kleber, Auteur ; Wera Teubner, Auteur ; Ben van Ravenzwaay, Auteur ; Robert Landsiedel, Auteur |
| Année de publication : |
2013 |
| Article en page(s) : |
p. 263-274 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Absorption
Evaluation
Expérimentation non animale
Ingrédients cosmétiques
Oeil -- Inflammation
Peau -- Inflammation
Relations structure-activité
Sensibilité cutanée
Tests de toxicité
Toxicologie
Toxicologie génétique
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
The use of alternatives to animal studies in toxicology is an ethical imperative and hence strongly recommended by current EU regulations.Particularly the 7th amendment of the cosmetic directive represents a major challenge to the chemical and cosmetics industry, since the safety of cosmetic ingredients is of paramount importance and must be ensured. Herein, we present examples of methods and strategies that are in accordance with the 3R principle and could be applicable today. Unfortunately, no validated replacement alternatives are available yet for several toxicological areas relevant to the cosmetic regulation and none are expected to become available in the near future. |
| Note de contenu : |
- Some aspect of the safety assessments of cosmetic products
- Evaluation of physical and chemical properties of cosmetic ingredients
- Use of the (Quantitative) structure-activity relationship (Q)SAR and "Read-across" from structurally related compounds
- Toxicological testing
- Acute (systemic) toxicity
- Eye irritation and corrosion
- Skin irritation and corrosion
- Skin sensitization
- Genotoxicity
- Alternatives for other toxicological endpoints : repeated dose toxicity and reproductive/developmental toxicity
- Skin absorption
- Exposure to cosmetic ingredients
- Concept of threshold of toxicological concern (TTC)
- Concluding remarks |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=20160 |
in IFSCC MAGAZINE > Vol. 16, N° 4 (10-11-12/2013) . - p. 263-274
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Toxicological testing of cosmetic ingredients using alternative methods - The supplier's perspective in IFSCC MAGAZINE, Vol. 16, N° 4 (10-11-12/2013)
