Combining science with nature for a new concept in skin fillers / Caverzan da Silva Jeanifer in SOFW JOURNAL, Vol. 146, N° 9 (09/2020)  

[article]  inSOFW JOURNAL > Vol. 146, N° 9 (09/2020) . - p. 18-23 Titre : Combining science with nature for a new concept in skin fillers Type de document : texte imprimé Auteurs : Caverzan da Silva Jeanifer, Auteur ; Patricia da Luz Moreira, Auteur ; Lilian Mussi, Auteur ; Wagner Magalhàes, Auteur Année de publication : 2020 Article en page(s) : p. 18-23 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Adipogenèse L'adipogenèse est le processus de différenciation cellulaire selon lequel des pré-adipocytes deviennent des adipocytes. Physiologiquement, il désigne aussi la fabrication du tissu adipeux et le stockage de lipides par les adipocytes. Elle est stimulé par l'hydroxycortisone. Il faut néanmoins le distinguer du terme lipogenèse qui désigne le processus biochimique. Antiâge Antiâge:Antirides Cosmétiques Etudes cliniques Evaluation Hyaluronane Thymus vulgaris Vieillissement cutané Visage -- Soins et hygiène Index. décimale : 668.5 Parfums et cosmétiques Résumé : Over time, physiological changes like the reduction of collagen and elastin production, as well as an overall decrease in skin metabolism and redox imbalance, result in significant aesthetic changes that include increased skin roughness, wrinkles, loss of elasticity and firmness, thinning of the skin, and the appearance of age spots. Additionally, bone retraction and the loss of adipose tissue (lipoatrophy) are also factors in the appearance of aging skin. Several studies have shown that the greater the facial lipoatrophy, the older it appears. To restore a more youthful appearance, dermal fillers are injected into the dermis to re-establish the volume lost to lipoatrophy. Seeking a non-invasive alternative to injectable fillers, Cellfie was developed as a plant-based ingredient that offers a precise and efficient delivery system that activates adipogenesis by stimulating adiponectin and PPARγ to ease the signs of aging. Both mediators were evaluated in vitro as well as the adipogenesis effect. A clinical study was performed using the Bio3D Structured-light Scanner to evaluate area, length, and depth of wrinkles on perioral, nasolabial, periorbital wrinkles and smile regions. Cellfie was found to effectively induce adipogenesis – stimulating skin filling and reducing the signs of aging. Note de contenu : - In vitro evaluation of adipogenesis - Clinical study - Fig. 1 : Life cycle of adipocytes – determination and differentiation throughout adipogenesis. Scheme from Lee MJ - Fig. 2 : Scheme showing the areas evaluated for wrinkles : perioral wrinkles, nasolabial lines, crow’s feet (periorbital wrinkles) and smile lines - Fig. 3 : Assessment on the induction of adipogenesis in the culture of predipocytes. Microscopy images at 40x magnification - Fig. 4 : Effect in the depth of perioral wrinkles - Fig. 5 : Effect in the depth of periorbital wrinkles (crow's feet) - Fig. 6 : Effect in the depth of smile lines - Fig. 7 : Effect in the depth of nasolabial lines - Fig. 8 : Effect on perioral, periorbital, smile line and nasola-bial wrinkles after 60 days of treatment En ligne : https://drive.google.com/file/d/18fdftx98nXqXBSIAt89I8B3k8jC86CWx/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=34624 [article]

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