Influence of surfactants on release of chlorhexidine from hydrogels / Zuzana Vitkovà in TENSIDE, SURFACTANTS, DETERGENTS, Vol. 48, N° 1/2010 (01-02/2011)

[article]  inTENSIDE, SURFACTANTS, DETERGENTS > Vol. 48, N° 1/2010 (01-02/2011) . - p. 48-52 Titre : Influence of surfactants on release of chlorhexidine from hydrogels Type de document : texte imprimé Auteurs : Zuzana Vitkovà, Auteur ; Jarmila Oremusovà, Auteur ; Anton Vitko, Auteur ; Z. Bezàkovà, Auteur Année de publication : 2011 Article en page(s) : p. 48-52 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Chlorhéxidine Concentration micellaire critique hydrocolloïdes Surfactants Index. décimale : 668.1 Agents tensioactifs : savons, détergents Résumé : In Slovakia chlorhexidine is available in dosage forms of solutions, creams and pastes but not in the form of hydrogels, though they are modern drug forms with many positive properties. Therefore, in this article possibilities of its formulation into hydrogels are studied. In particular, two research aims were followed. The first consisted in study of an influence of surface active agents on the release of chlorhexidine dihydrochloride from chitosan hydrogels and the second one was to design a formulation of hydrogels for local delivery of chlorhexidine to the oral cavity. To this end, surfactants from the group of alkyltrimethylammonium bromides with the length of alkyl chain C6–C18 which occupy a dominant position in the indication group of antiseptics and disinficients were analyzed with intention to use them in preparation of hydrogels. Hydrogels were prepared with 2.5% (w/w) gel-forming agent chitosan. Both the active agent and surfactants were used in 0.1% (w/w) concentration. It is shown that the surface active agents with short alkyl chain are suitable for development of chlorhexidine dihydrochloride hydrogels with controlled release. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10670 [article]

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Study of micelle properties and thermodynamics of micellization of the benzethonium chloride / Jarmila Oremusovà in TENSIDE, SURFACTANTS, DETERGENTS, Vol. 49, N° 4 (07-08/2012)

[article]  inTENSIDE, SURFACTANTS, DETERGENTS > Vol. 49, N° 4 (07-08/2012) . - p. 322-329 Titre : Study of micelle properties and thermodynamics of micellization of the benzethonium chloride Type de document : texte imprimé Auteurs : Jarmila Oremusovà, Auteur ; Zuzana Vitkovà, Auteur ; Anton Vitko, Auteur Année de publication : 2012 Article en page(s) : p. 322-329 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Chlorure de benzéthonium Concentration micellaire critique Conductimétrie Densitométrie Potentiométrie Résonance magnétique nucléaire Spectrophotométrie UV-Visible Spectroscopie de fluorescence Surfactants Index. décimale : 668.1 Agents tensioactifs : savons, détergents Résumé : The self-association of benzethonium chloride (BZCl) in aqueous solution has been analyzed as a function of temperature. The critical micelle concentration (CMC.), the degree of counterion binding (β) and thermodynamic parameters of micellization (molar Gibbs energy, enthalpy and entropy of micellization) were determined using six experimental methods (conductometry, potentiometry, UV spectrophotometry, spectrofluorimetry, NMR and densitometry) within the temperature range 20 – 50 °C. All methods used gave very similar values for CMC. Changes in the thermodynamic parameters on micellization were determined by applying a mass action model. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=15552 [article]

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