Blackberry leaf extract : a multifunctional anti-aging active / Martina Herrmann in IFSCC MAGAZINE, Vol. 10, N° 1 (01-02/2007)

[article]  inIFSCC MAGAZINE > Vol. 10, N° 1 (01-02/2007) . - p. 41-45 Titre : Blackberry leaf extract : a multifunctional anti-aging active Type de document : texte imprimé Auteurs : Martina Herrmann, Auteur ; Susanne Grether-Beck, Auteur ; Imke Meyer, Auteur ; Helge Franke, Auteur ; Holger Joppe, Auteur ; Jean Krutmann, Auteur ; Gabriele Vielhaber, Auteur Année de publication : 2007 Article en page(s) : p. 41-45 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Extrait  de  feuille  Blackberry'  'Balayage  radical'  'Rubus  fructicosus'  'Anti-âge'  'Mmp-1'  'Il-1?' Index. décimale : 668.5 Parfums et cosmétiques Résumé : Matrix metalloproteinases (MMPs) play a major role in wrinkle formation. Their expression increases with aging and is further enhanced by UV irradiation. Blackberry (Rubus fruticosus) leaf extract has been shown to suppress MMP-1, -2 and -9 in cell-free assays. We have now further explored the activity of this extract. The effect on MMP-1 expression at the protein and the mRNA level was investigated using non-irradiated and UVA-irradiated human dermal fibroblasts. The extract showed a dose-dependent reduction of the MMP-1 protein level of both irradiated and non-irradiated cells with an almost complete inhibition at a dosage of 0.1%. MMP-1 mRNA expression of UVA-irradiated cells was decreased after pre-incubation as well as after post-incubation with the extract. Best results were obtained with combined pre- and post-treatment (0.1% extract led to 59% reduction in comparison with the respective control). Moreover, we found that blackberry leaf extract inhibits IL-1α, a cytokine known to induce MMP expression. At a dosage of 0.2% the inhibition was 40% compared with that of the stimulated control. The extract also exhibited a potent radical scavenging activity comparable to that of α-tocopherol as was shown by the ABTS assay. Taken together, these biological activities make blackberry leaf extract a highly efficient multifunctional anti-aging active. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10428 [article]

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Study data confirm global antipollution activity / Silke Schagen in PERSONAL CARE EUROPE, Vol. 11, N° 2 (04/2017)  

[article]  inPERSONAL CARE EUROPE > Vol. 11, N° 2 (04/2017) . - p. 126-128 Titre : Study data confirm global antipollution activity Type de document : texte imprimé Auteurs : Silke Schagen, Auteur ; Sabrina Overhagen, Auteur ; Susanne Grether-Beck, Auteur ; Jean Krutmann, Auteur ; Andreas Bilstein, Auteur ; Eva Galik, Auteur Année de publication : 2017 Article en page(s) : p. 126-128 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anti-inflammatoires Biomolécules actives Peau -- Effets de la pollution atmosphérique Peau -- Soins et hygiène Protection cutanée Index. décimale : 668.5 Parfums et cosmétiques Résumé : Latest scientific evidence confirms, that air pollution contributes to premature skin ageing and may even be the primary cause of ageing in some cases. Especially for particulate matter and polycyclic aromatic hydrocarbons (PAHs) negative influence on skin integrity has been shown. The natural stress-protection molecule Ectoin® is well known to strengthen the skin barrier function, to work against variable stressors such as UVA/UVB radiation, IR-A, visible light or allergens, and for its anti-inflammatory activity. This study demonstrates the global protection and prevention efficacy of Ectoin from air pollution induced skin damage. Ectoin is well suited for topical antipollution products targeting skin pigmentation and accelerated ageing as well as particle stressed and irritated skin. Note de contenu : - FIGURES : Pollution particles to induce POMC expression in keratinocytes - Pollution particles to induce MMP1 expression in keratinocytes - Pollution particles to induce Cyp1A1 expression in keratinocytes - Up-regulation of A) POMC, B) NMP1 ane C) Cym 1A1 mRNA expression in primary human keratinocytes (Asian and Caucasian) by sub-toxic amounts of ultrafine and fine carbon black particles and by two different types of exhaust particulates. 18S ribosomal RNA (rRNA) was used as a POMC overexpression. The remaining response is calculated by setting the pollution induced effect equal 100% B, C) Ectoin reduces MMP1 and Cyp 1A1 up-regulation and protects keratinocytes also from fine carbon black particle and diesel particulate matter - 2. In vivo study design, smoke application with standardised chamber system - 3. Cigarette smoke application on the volar forearm - after only 5 days of application with 1% Ectoin the pollution induced MDA content in the skin was reduced by 48% compared to the placebo treated areas. A strong anti-oxidant (gold standard) was able to reduce the pollution-induced MDA content in the skin by 27% (data not shown) En ligne : https://drive.google.com/file/d/1pyp0JC-G2uNE-LMat0KXsvfe-b7nMp5D/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=28350 [article]

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