Agastache mexicana counteracts the effects of psychological stress on skin / Laura Gallego in SOFW JOURNAL, Vol. 142, N° 5 (05/2016)  

[article]  inSOFW JOURNAL > Vol. 142, N° 5 (05/2016) . - p. 8-16 Titre : Agastache mexicana counteracts the effects of psychological stress on skin Type de document : texte imprimé Auteurs : Laura Gallego, Auteur ; Blanca Martinez-Teipel, Auteur ; Ricard Armengol, Auteur Année de publication : 2016 Article en page(s) : p. 8-16 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anti-inflammatoires Biomolécules actives Cosmétiques Extraits de plantes:Extraits (pharmacie) Peau -- Soins et hygiène Stress -- Effets physiologiques Index. décimale : 668.5 Parfums et cosmétiques Résumé : Nowadays, psychological stress is a very relevant aspect in daily life. lt occurs as a result of a stimulus, which leads to the activation of several physiological systems among them the activation of the HPA axis. Once activated it causes the release of key stress molecules which leads further to a profound alteration of immune responses. The inflammatory reaction itself is managed by the nuclear factor (NF)-kappa B, which is able to translocate to the cell nucleus once psychological stress is detected. In the nucleus it binds to the DNA inside the cell to regulate the expression of numerous components of the immune system. if stress becomes a chronic situation our organism reaches a phase of exhaustion with adverse consequences. Related to our skin, such consequences could be the outbreak or worsening of several disorders such as rosacea, psoriasis and other inflammatory events like acne. Our laboratory has developed an active, derived from Agastache mexicana, capable of counteracting the consequences that psychological stress can unleash on the skin. It has been successfully demonstrated that this natural active is able to inhibit the translocation of NF-KB to the nucleus in Keratinocytes. lt has also been confirmed that the active inhibits the release of highly up-regulated cytokines. In vivo studies have shown a reduction of continued vasodilation by between 25 and 30 %. It also enables capillaries to recover their ability to contract and improve their strength and integrity, reducing skin redness. By using a thermal camera it was shown that this active reduces skin temperature by 0.4 degrees in subjects with stress and/or skin prone to develop rosacea. Chromameter measurements showed a reduction of skin redness by 9%. The active also confirmed a positive impact on the skin barrier as it reduced skin water loss by 13 % and an improvement of skin hydration by 6 %. The natural active AgascalmTM derived from Agastache mexicana can be strongly recommended as an active ingredient with excellent anti-inflammatory activity that modulates the biochemical mechanisms that link psychological stress with skin deterioration. Note de contenu : - INTRODUCTION : The brain-skin link - Consequences and signs of psychological stress in skin - Natural options to counteract psychological effects on skin - MATERIALS AND METHODS : In vitro : NF-κB translocation - In situ immunolabeling - Transcriptional effects - RtqPCR array - Cytokines release - Cytometric bead array - Instrumental analysis - Evaluation of the skin microvascular tonicity - Evaluation of the anti-redness efficacy - Color analyzer - Imagine analysis - Evaluation of the skin barrier and moisturizing - Skin barrier by transepidermal water loss - Skin moisturizing by corneometry - Statistical data analysis - RESULTS AND DISCUSSION : In vitro : NF-κB translocation - In situ immunolabeling - Transcriptional effect - RT-qPCR array - Cytokines release - Cytometric bead array - In vivo : Evaluation of the skin microvascular tonicity - Evaluation of the anti-redness efficacy - Evaluation of the skin barrier and moisturizing improvement En ligne : https://drive.google.com/file/d/1BqB_D4yi6Sc3b4AYSfk8DYKRINGQcLqV/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=26315 [article]

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Combined forces work to restore skin firmness / Ricard Armengol in PERSONAL CARE EUROPE, Vol. 3, N° 4 (11/2010)  

[article]  inPERSONAL CARE EUROPE > Vol. 3, N° 4 (11/2010) . - p. 23-26 Titre : Combined forces work to restore skin firmness Type de document : texte imprimé Auteurs : Ricard Armengol, Auteur ; Blanca Martinez-Teipel, Auteur ; Emilio Rubio, Auteur Année de publication : 2010 Article en page(s) : p. 23-26 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge Biomolécules actives Cosmétiques Vieillissement cutané Index. décimale : 668.5 Parfums et cosmétiques Résumé : Zirhafirm stregthens the internal skin structure with active ingredients that cooperate to synergistically enhance dermo-epidermal communication and cohesion thus reducing flaccidity. It recovers the firmness of the skin providing a more defined facial contour. En ligne : https://drive.google.com/file/d/1jUWfJQ-lOuWFaopy5u3u6-IF3-sFJfxt/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10258 [article]

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Mitophagy activation - a novel anti-ageing cosmetic target / Emilio Rubio in SOFW JOURNAL, Vol. 143, N° 6 (06/2017)  

[article]  inSOFW JOURNAL > Vol. 143, N° 6 (06/2017) . - p. 2-9 Titre : Mitophagy activation - a novel anti-ageing cosmetic target Type de document : texte imprimé Auteurs : Emilio Rubio, Auteur ; Miguel Perez-Aso, Auteur ; Jordi Bosch, Auteur ; Ricard Armengol, Auteur ; Blanca Martinez-Teipel, Auteur ; Hagen Döring, Auteur ; Esther Seco, Auteur ; Ana Serrano-Puebla, Auteur ; Patricia Boya, Auteur Année de publication : 2017 Article en page(s) : p. 2-9 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge Dermo-cosmétologie Mitophagie Peau -- Soins et hygiène Index. décimale : 668.5 Parfums et cosmétiques Résumé : Mitophagy is a selective quality control process that targets and degrades damaged mitochondria. Mitophagy is impaired with age, contributing to mitochondrial and cellular dysfunction. Therefore, we hypothesized that boosting mitophagy would keep oxidative toxicity in check and recover function in aged skin cells, thus leading to a visible rejuvenation effect in vivo. Compounds were screened for mitophagy in SH-SY5Y cells with a nove] flow cytometry-based approach. We identified a combination of Paeoniflorin and Trehalose (PF/TH) that synergisticaily induced mitochondrial renewal through mitophagy activation. This activity was confirmed in Normal Human Dermal Fibroblasts (NHDF). A set of assays on NHDF and senescent human dermal fibroblasts were designed to explore cellular responses to mitophagy activation by PF/TH. Our results revealed an anti-ageing activity profile, via restoring collagen to levels found in young cells and reversing other characteristic ageing signs : ATP decrease, MMP-1 release and 8-galactosidase positive cells. Fibroblasts also became more resilient towards mitochondrial damage and oxidative stress, as showed by insults with CCCP and pyrogallol. Finally, a clinical study on aged volunteers confirmed rejuvenating effects achieved by FP/TH active. These results support mitophagy activation as a target for cosmetic anti-ageing applications. Note de contenu : - EXPERIMENTAL : In vitro studies - Clinical study - RESULTS : Mitochondrial recycling : mitophagy - Mitochondrial quality : mitochondrial membrane potential - Mitochondrial function AT° - Oxidative stress - Senescence in ageing models - Ageing markers - In vivo rejuvenating effects En ligne : https://drive.google.com/file/d/1_B4ZN6mvGEsUbrczqA5DjXlEoyp-ZKT2/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=28726 [article]

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Natural solution for damaged and weakened hair / Ricard Armengol in PERSONAL CARE EUROPE, Vol. 4, N° 2 (06/2011)  

[article]  inPERSONAL CARE EUROPE > Vol. 4, N° 2 (06/2011) . - p. 67-70 Titre : Natural solution for damaged and weakened hair Type de document : texte imprimé Auteurs : Ricard Armengol, Auteur ; Blanca Martinez-Teipel, Auteur ; Aurora Benaiges, Auteur Année de publication : 2011 Article en page(s) : p. 67-70 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cheveux -- Propriétés mécaniques Cheveux -- Soins et hygiène Microscopie électronique à balayage Perméabilité Produits capillaires Index. décimale : 668.5 Parfums et cosmétiques Résumé : Keratrix increases hair strength and elasticity, improves dry and weak hair, and repairs the damage caused by mechanical, thermal and chemical processes. Its sustained release system allows it to remain on the hair fibre for a prolonged action. Note de contenu : - HAIR FIBRE - HAIR PROPERTIES : permeability - Elasticity - Tensile strength - COMPOSITION - EX VIVO EFFICACY : Methodology - SEM microscopy - Mechanical properties - Sorption experiments En ligne : https://drive.google.com/file/d/1dE5dSiw-E-cmrCCn-hxD_SofUarGeP4b/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=13422 [article]

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Nature's know-how and plant cell technology to combat infrared- and ultraviolette-induced photoaging / Hagen Döring in SOFW JOURNAL, Vol. 142, N° 11 (11/2016)  

[article]  inSOFW JOURNAL > Vol. 142, N° 11 (11/2016) . - p. 2-8 Titre : Nature's know-how and plant cell technology to combat infrared- and ultraviolette-induced photoaging Type de document : texte imprimé Auteurs : Hagen Döring, Auteur ; Emilio Rubio, Auteur ; Miguel Perez-Aso, Auteur ; Blanca Martinez-Teipel, Auteur ; Jordi Bosch, Auteur ; Ricard Armengol, Auteur Année de publication : 2016 Article en page(s) : p. 2-8 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anti-inflammatoires Antiâge:Antirides Antioxydants Biomolécules actives Cosmétiques Dermo-cosmétologie Extraits de plantes:Extraits (pharmacie) Peau -- Soins et hygiène Vieillissement cutané -- Prévention Index. décimale : 668.5 Parfums et cosmétiques Résumé : The term Photoaging describes the ageing process of our skin that is caused by ultraviolet (UV) and infrared (IR) solar radiation. UV - and IR - induced damage to our skin includes, but is not limited to, DNA alterations, an increased level of cellular oxidative stress and inflammatory reaction in our skin. All of these processes lead to premature ageing and poor biomechanical characteristics. Our laboratory has developed the active ingredient Lingostem, which is based on a polyphenolrich lingonberry (Vaccinium vitis-idaea) cell line. The anti-oxidative capacity was 11 times higher than that of the natural berries. Lingostem counteracts the negative effects of IR and UV radiation by potentiating the antioxidant response, decreasing the inflammatory reaction and reducing MMP-1 production. Two independent in vivo studies showed the protective and restorative capacity of Lingostem. Especially impressive were the improvement of the sub-epidermal echogenic band and a significant wrinkle reduction relative to placebo. Note de contenu : - PLANT CELL TECHNOLOGY - METHODS : DPPH Free Radical Scavenging activity - Cell Culture and Irradiation Conditions - Quantitative RT-PCR after UV-B Irradiation - Evaluation of p38 phosphorylation after IR-A Irradiation - Evaluation of Hydrogen Peroxide Production after IR-A Irradiation - Quantitative RT-PCR: MMP-1 after IR-A Irradiation - In vivo Photoaging Studies - RESULTS : DPPH Free Radical Scavenging Activity - Anti-inflammatory Effect after UV-B: Quantitative RT-PCR - Effect on p38 Activation Induced by IR-A - Cellular Oxidative Stress: Evaluation of Hydrogen Peroxide after IR-A Irradiation - Effect on Gene Expression after IR-A Irradiation: MMP-1 - In vivo Photoaging Studies En ligne : https://drive.google.com/file/d/1mmwV2v9Rv8QgRNfIXQoI1tfq43a1Pdjf/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=27851 [article]

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Protecting hair fibre and colour from solar radiation / Ricard Armengol in PERSONAL CARE EUROPE, Vol. 4, N° 4 (11/2011)  

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