Development of computational models for the risk assessment of cosmetic ingredients / Soheila Anzali in IFSCC MAGAZINE, Vol. 15, N° 4 (10-11-12/2012)

[article]  inIFSCC MAGAZINE > Vol. 15, N° 4 (10-11-12/2012) . - p. 249-255 Titre : Development of computational models for the risk assessment of cosmetic ingredients Type de document : texte imprimé Auteurs : Soheila Anzali, Auteur ; Michael R. Berthold, Auteur ; Elena Fioravanzo, Auteur ; Daniel Neagu, Auteur ; Alexandre RR Péry, Auteur ; Andrew P. Worth, Auteur ; Chihae Yang, Auteur ; Mark T. D. Cronin, Auteur ; Andrea-Nicole Richarz, Auteur Année de publication : 2012 Article en page(s) : p. 249-255 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Bases de données Evaluation du risque Ingrédients cosmétiques Inventaires Toxicologie Index. décimale : 668.5 Parfums et cosmétiques Résumé : The COSMOS Project (Integrated in Silico Models for the Prediction of Human Repeated Dose Toxicity of COSMetics to Optimise Safety, www.cosmostox.eu) is a unique international collaboration addressing the safety assessment needs of the cosmetics industry, without the use of animals. COSMOS is developing an integrated suite of computational workflows including models based on the threshold of toxicological concern (TTC) approach, innovative toxicity prediction strategies based on chemical categories based on chemical categories, read-across and quantitative structure-activity relationships (QSARs) related to key events in adverse outcome pathways and multi-scale modeling based on physiologically-based pharmacokinetics to predict target organ concentrations and extrapolate from in vitro to in vivo exposure scenarios. The KNIME technology is being used to integrate access to databases and modeling approaches into flexible computational workflows that will be made publicly accessible and provide a transparent method for use in the safety assessment of cosmetics. First results include establishing the COSMOS chemical inventory of cosmetic ingredients and their associated chemical structures ; a new dataset for TTC analysis for assessment of the applicability of the TTC approach to cosmetics ; developing the COSMOS database for repeated dose toxicity data ; as well as KNIME workflows to identify structural rules, fragments and properties associated with particular mechanisms of toxicity. Note de contenu : - An inventory of cosmetic ingredients - COSMOS database - Threshold of Toxicological Concern (TTC) adapted to cosmetic ingredients - Prediction of toxicity : from mechanism to model Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=16883 [article]

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Elucidation of the anti-aging effects of ectoine using cdna microarray analysis and signaling pathway evaluation / Soheila Anzali in IFSCC MAGAZINE, Vol. 12, N° 4 (10-11-12/2009)

[article]  inIFSCC MAGAZINE > Vol. 12, N° 4 (10-11-12/2009) . - p. 381-385 Titre : Elucidation of the anti-aging effects of ectoine using cdna microarray analysis and signaling pathway evaluation Type de document : texte imprimé Auteurs : Soheila Anzali, Auteur ; Anja von Heydebreck, Auteur ; Thomas Herget, Auteur Année de publication : 2010 Article en page(s) : p. 381-385 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge Cosmétiques Ectoine Index. décimale : 668.5 Parfums et cosmétiques Résumé : A human three-dimensional skin model was treated with ectoine in two different concentrations for four days. Gene expression profiling was performed using cDNA microarray analysis. A network analysis of the deregulated genes yields hypotheses regarding potential molecular mechanisms leading to anti-aging effects of ectoine. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10142 [article]

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In vivo anti-aging efficacy of a cyclic peptide composition / Ruediger Graf in IFSCC MAGAZINE, Vol. 15, N° 1 (01-02/2012)

[article]  inIFSCC MAGAZINE > Vol. 15, N° 1 (01-02/2012) . - p. 23-27 Titre : In vivo anti-aging efficacy of a cyclic peptide composition Type de document : document électronique Auteurs : Ruediger Graf, Auteur ; Karl-August Reiffen, Auteur ; Soheila Anzali, Auteur ; Ulrike Heinrich, Auteur ; Hagen Tronnier, Auteur ; Hansjürgen Driller, Auteur ; Frank Pfluecker, Auteur Année de publication : 2012 Article en page(s) : p. 23-27 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Antiâge:Antirides Intégrine Matrice extracellulaire Peptides cycliques Index. décimale : 668.5 Parfums et cosmétiques Résumé : Aging affects the composition and morphological structure of the different compartments of the skin. Integrins, as an important family of transmembrane receptors, play a key role in cell-matrix interactions and are involved in cell signaling. Binding of specific ligands within the extracellular matrix to these receptors is a crucial step to maintain a vital tissue structure. For this reason a selective cyclic peptide containing an arginine-glycine-aspartic acid (RGD) sequence was designed for cosmetic applications. The objective of the present work was to evaluate the binding efficiency of different RGD peptides to specific integrins. The cyclic RGD peptide was tested in a placebo-controlled study with human volunteers with respect to its anti-aging efficacy in vivo. The results of the ligand inhibition assay with immobilized integrins clearly demonstrated that only the cyclic conformation of the RGD motif motively binds to the integrin receptors In terms of anti-aging properties, this in vivo trial confirmed the results of previous in vitro investigations where a positive effect on wrinkle reduction was observed. Our present work again supports the hypothesis that this specific RGD peptide composition successfully mimics the biological function of extracellular matrix proteins by activating signaling pathways and targets involved in the prevention of aging. Note de contenu : - EXPERIMENTAL : Ligand inhibition assay with immobilized integrins - Statistical evaluation of the in vivo data - RESULTS AND DISCUSSION : Ligand inhibition assay - In vivo volunteer study : impact on wrinkle volume and anti-aging efficacy Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=13671 [article]

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