| Titre : |
The youth protein klotho : new target for anti-ageing |
| Type de document : |
texte imprimé |
| Auteurs : |
Gabrielle Moro, Auteur ; Pierre-Yves Morvan, Auteur ; Romuald Vallée, Auteur |
| Année de publication : |
2014 |
| Article en page(s) : |
p. 62-64 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Antiâge
Biomolécules actives
Cosmétiques
Extraits de plantes:Extraits (pharmacie)
Fibroblastes
Peau -- Soins et hygiène
Protéine klotho
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
The klotho gene was identified for the first time in 1997 in mice.i Its mutation causes a premature apparition of all the traditional signs of ageing and leads to premature death. On the other hand, when it is overexpressed, this gene leads to a 20% to 30% increase in mice lifespan. The skin of klotho-deficient mice is thin and atrophic. Histological examination shows reduced number of hair follicles and reduced thickness of the dermal and epidermal layers.
The klotho protein is available in two forms : the transmembrane form and the secreted forme which have distinct functions but can collectively affect ageing processes. Secreted klotho is involved in a large number of signalling pathways leading to the re-establishment of optimal cellular function, among them it has been suggested that klotho may inhibit the insulin/IGF-1 signalling pathway (Fig. 2) and thus participate in the suppression of oxidative stress via Forkhead box (FOXO). FOXOs up-regulate expression of multiple genes, including antioxidant enzymes such as catalase. These FOXO are negatively regulated by insulin/IGF-1 signalling. Indeed, activation of insulin/IGF-1 signalling increases activity of a serine-threonine kinase Akt, which in turn phosphorylates FOXOs. Phosphorylated FOXOs are excluded from the nucleus and are unable to function as transcription factors. By inhibiting the insulin/IGF-1 signalling pathway, klotho down-regulate AKT and promote the predominance of the unphosporylated FOXOs.
Codif International laboratories have demonstrated a direct link between klotho expression and fibroblast ageing (Fig. 3). The decrease in klotho expression starts very early during the ageing process : from roughly 30 years. Then its expression gradually decreases with fibroblast ageing. Increasing klotho synthesis in the fibroblasts thus represents a new strategy to combat skin ageing.
We demonstrate here the capacity of a liposoluble extract of Tears of Chios (Fig. 1): Lakesis, to up-regulate klotho synthesis in ageing fibroblasts for global anti-ageing applications. |
| Note de contenu : |
- Activation of youth proteins and antioxidant enzymes
- Use of 3D models to visualise dermis redensification process
- In vivo anti-ageing efficacy |
| En ligne : |
https://drive.google.com/file/d/1WH_pNHe2MVf-6zdDy7cs7Vnpl4CVUX_H/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=21598 |
in PERSONAL CARE EUROPE > Vol. 7, N° 4 (06/2014) . - p. 62-64
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