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Improving cellular function through modulation of energy metabolism / D. Maes in IFSCC MAGAZINE, Vol. 7, N° 2 (04-05-06/2004)
[article]
Titre : Improving cellular function through modulation of energy metabolism Type de document : document électronique Auteurs : D. Maes, Auteur ; Donald Collins, Auteur ; Lieve Declercq, Auteur ; Reyhaned Foyouzi-Youssefi, Auteur ; David Gan, Auteur ; Thomas Mammone, Auteur ; Edward Pelle, Auteur ; Ken Marenus, Auteur ; Harvey Gedeon, Auteur Année de publication : 2004 Article en page(s) : p. 121-126 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Adénosine triphosphate' Energie 'Métabolisme énergétique' Mitochondrie Senescence 'exposition aux UV' Index. décimale : 668.5 Parfums et cosmétiques Résumé : The ambivalent consequences of mitochondrial stimulation on cellular activity have been well established. Mitochondria supply the cell with energy through a process of oxidative phosphorylation but thereby generate free radicals, resulting in the accumulation of hydrogen peroxide in the cytoplasm. We have investigated the impact of cellular senescence as well as UV irradiation, on the balance between these two activities.
The adenosine triphosphate (ATP) level, DNA and protein synthesis in fibroblasts obtained from donors between 30 and 90 years of age appeared to be significantly influenced by the aging process. Both DNA and protein synthesis could be stimulated by increasing intracellular ATP levels. In-vitro senescent fibroblasts showed a reduction in the level of ATP as well as a shift in mitochondrial membrane potential. At the same time, there was an increase in intracellular hydrogen peroxide with increasing population doubling, indicating a clear dysfunction of the metabolic machinery in the mitochondria of senescent cells. To counteract this degradation of the energy pool, we treated cells with creatine, which is known to restore the pool of phosphocreatine in the mitochondria. Creatine treatment significantly increased cell survival after UV exposure, stimulated the repair of UVB-induced DNA damage in keratinocytes and caused a significant reduction in the number of sunburn cells in a UVB-exposed reconstituted skin model. These results clearly indicate that restoration of the energy pool in mitochondria increased cellular self-defense mechanism. These data show the important role played by the mitochondrial energy metabolism on the aging process, and indicate a possible therapy that can be used to counteract this negative effect. Treatment with creatine seems to provide the necessary boost to the cellular metabolism, which leads to an induction of a significant amount of protection and repair to human skin cells.Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10526
in IFSCC MAGAZINE > Vol. 7, N° 2 (04-05-06/2004) . - p. 121-126[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 003883 - Périodique Bibliothèque principale Documentaires Disponible Cell-activating effects of a viniferin-enriched grapevine extract / Olaf Holtkötter in IFSCC MAGAZINE, Vol. 12, N° 2 (04-05/2009)
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Titre : Cell-activating effects of a viniferin-enriched grapevine extract Type de document : texte imprimé Auteurs : Olaf Holtkötter, Auteur ; Claudia Jassoy, Auteur ; Andreas Bock, Auteur ; Marianne Waldmann-Laue, Auteur ; Frank JanBen, Auteur Année de publication : 2009 Article en page(s) : p.101-105 Note générale : Bibliogr. Langues : Anglais (eng) Tags : Fibroblast Collagen contraction Confocal laser microscopy Resveratrol Senescence Index. décimale : 668.5 Parfums et cosmétiques Résumé : Extracts of grapevine, especially in the fermented form of wine, are reported to exert beneficial effects to human health. Grapevine polyphenols are considered to be the main compounds responsible for this beneficial activity, and of these, resveratrol has been studied in most detail. Because of its antioxidant properties, resveratrol demonstrates cell protective characteristics, but it is also able to reduce cell proliferation and induce apoptosis, especially in cancer cells. Investigations on the effects of resveratrol on UVB irradiated primary keratinocytes and HaCats have demonstrated protective properties also in skin cells.
Although grapevine extracts are routinely used as an active ingredient in skincare cosmetics, the activity of these extracts on skin, apart from that of resveratrol, is only poorly understood. Here the effects on skin cells of a grapevine extract enriched with the resveratrol dimer (epsilon)-viniferin were analyzed in vitro and in vivo.Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=6099
in IFSCC MAGAZINE > Vol. 12, N° 2 (04-05/2009) . - p.101-105[article]Réservation
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Code-barres Cote Support Localisation Section Disponibilité 011489 - Périodique Bibliothèque principale Documentaires Disponible