[article]
| Titre : |
Bicontinuous microemulsion as reaction medium for ω-transaminase catalysed biotransformations |
| Type de document : |
texte imprimé |
| Auteurs : |
M. Laupheimer, Auteur ; S. Engelskirchen, Auteur ; K. Tauber, Auteur ; W. Kroutil, Auteur ; C. Stubenrauch, Auteur |
| Année de publication : |
2011 |
| Article en page(s) : |
p. 28-33 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Aminoacyltransférases
Biotransformation (métabolisme)
Catalyse enzymatique
Microémulsions
Réactions chimiques
|
| Tags : |
'Microémulsion bi-continue' Métabolisation 'Réaction enzymatique' 'Incompatibilité enzyme/substrat' de milieu' |
| Index. décimale : |
668.1 Agents tensioactifs : savons, détergents |
| Résumé : |
Due to their high enantioselectivity biotransformations, i.e. enzyme-catalysed conversion of organic compounds, are extremely attractive reactions. However, a limiting factor for choosing substrates is the enzyme-substrate incompatibility. This occurs when a hydrophilic enzyme which naturally resides in the aqueous cell cytoplasm is supposed to convert a hydrophobic substrate. In this context bicontinuous microemulsions appear to be a beneficial reaction medium for biotransformations, particularly due to their large interfacial area between a hydrophilic and a hydrophobic compound. As a "proof of concept" we performed ω-transaminase (EC 2.6.1.18) catalysed model reactions in a bicontinuous microemulsion of the type phosphate buffer/NaCl – n-octane – pentaethylene glycol monodecyl ether. |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10667 |
in TENSIDE, SURFACTANTS, DETERGENTS > Vol. 48, N° 1/2010 (01-02/2011) . - p. 28-33
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