Accueil
Catégories
Ajouter le résultat dans votre panier Affiner la recherche
Etendre la recherche sur niveau(x) vers le bas
Innovative active fights zombie cells for well-ageing / Pascale Prouheze in PERSONAL CARE EUROPE, Vol. 14, N° 3 (06/2020)
[article]
Titre : Innovative active fights zombie cells for well-ageing Type de document : texte imprimé Auteurs : Pascale Prouheze, Auteur ; Jessica Guglielmi, Auteur ; Barbara Morand, Auteur ; Frédéric Maccario, Auteur ; Pierre-Gilles Markioli, Auteur ; Noëlle Garcia, Auteur ; Mélanie Mollet, Auteur ; Lionel Valenti, Auteur ; Emmanuel Coste, Auteur Année de publication : 2020 Article en page(s) : p. 21-24 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Anti-inflammatoires
Antiâge
Biomolécules actives
Peau -- Soins et hygiène
Polyphénols
ScutalineIndex. décimale : 668.5 Parfums et cosmétiques Résumé : Senescence is a cellular response characterised by morphological changes, a stable growth arrest (in order to prevent tumoral proliferation) and a change in the cell’s secretome.
Indeed, senescent cells, called Zombie cells, produce a large amount of senescence-associated secretory phenotype (SASP) which is responsible for a pro-inflammatory response, for collagen degradation, for free radical production, and for the transmission of the senescent state.1 As a result, senescent cells tend to accumulate with age and 20 to 60% of the skin cells are actually senescent.
The senescence process may be induced by several causes. Ageing is the most common phenomenon (after a certain number of division, a cell may go into senescence), but another frequent cause is stress, especially oxidative stress that induces inflammation. The combination of ageing and moderated inflammation caused by stress is called inflamm’aging, also known as “secret killer”. This progressive and insidious phenomenon has visible effects in the long term and prevents the skin from ageing well.
When a cell is exposed to stress, there are a few possible outcomes. It can be repaired, it can undergo apoptosis (the programme cell death) if it is too severely damaged, or it can undergo senescence.
Apoptosis will induce a high energy expenditure since the cell will have to be replaced and requires the division of a healthy cell. The same is true for necrosis, which consumes less energy but also requires the remaining healthy cells to replace the eliminated cell. These two processes cause a significant energy impact for the body, and therefore for the skin.
Senescent cells still maintain their production activities although in a degraded form. Senescence thus seems to be an acceptable compromise at a lower energy cost. However, senescence is a source of extensive and chronic inflammation as described before, the inflamm’aging.
Scutaline (INCI name : Scutellaria baicalensisroot extract) is an active ingredient made from the dried roots of the Scutellaria baicalensis, a plant traditionally used in Chinese medicine and naturally rich in two polyphenols: Baicalein and Wogonin that have been described to reduce SASP .3 Baicalein is an activator of the Nrf2 pathway. It thus provides strong antioxidative benefits by stimulating the production of anti-oxidants such as NADP(H): Quinone oxidoreductase 1 (NQO1) and glutathione.4 Baicalein is also a COX-2 inhibitor.5 It therefore inhibits prostaglandin (PGE2) synthesis and participates in reducing inflammatory symptoms like redness and pain.
Wogonin is a NFkB inhibitor that provides potent anti-inflammatory benefits.6 It is also responsible for degrading HIF-1a (hypoxia inducible factor-1a) that is key for regulating the angiogenesis process that may limit inflammation and redness.7 Using a patented extraction method, the concentration of these two molecules was maximised for stronger benefits to the skin.
We focused on a strategy consisting of slowing the entry of cells into senescence during ageing and also decreasing the ability of senescent cells to affect nearby healthy cells and to cause a chronic lowgrade inflammation leading to skin premature ageing.
In this paper, we will present how Scutaline (referred to as ‘Scutellaria baicalensis root extract’) is able to meet our strategy to help the skin to age well.Note de contenu : - Preventing stress-induced senescence
- Decreasing the ability of senescent cells to promote senescence and to cause inflamm'aging
- Benefits for the skinEn ligne : https://drive.google.com/file/d/1V1MeuLBm2ZcUdoj9bhdSUeDewqnXSBvo/view?usp=drive [...] Format de la ressource électronique : Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=34274
in PERSONAL CARE EUROPE > Vol. 14, N° 3 (06/2020) . - p. 21-24[article]Réservation
Réserver ce document
Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité 21749 - Périodique Bibliothèque principale Documentaires Disponible