Prebiotic effect of galacto-oligosaccharides on the skin microbiota and determination of their diffusion properties / Anja Petrov in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 44, N° 3 (06/2022)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 44, N° 3 (06/2022) . - p. 309-319 Titre : Prebiotic effect of galacto-oligosaccharides on the skin microbiota and determination of their diffusion properties Type de document : document électronique Auteurs : Anja Petrov, Auteur ; Marija Corovic, Auteur ; Milica Simovic, Auteur ; Katarina Banjanac, Auteur ; Rada Pjanovic, Auteur ; Dejan Bezbradica, Auteur Année de publication : 2022 Article en page(s) : p. 309-319 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Absorption cutanée Cosmétiques Dermo-cosmétologie Formulation (Génie chimique) Galacto-oligosaccharides Un galacto-oligosaccharide est un élément naturel présent dans les graines et dans les organes souterrains des légumes secs (haricots, pois chiches...). Ils jouent un rôle de réserves et de protection contre le gel. (Wikipedia) Microbiote cutané Peau -- Soins et hygiène Prébiotiques Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Recently, prebiotics are attracting plenty of attention in the field of skin care, since it is found that they are able to support the balance of beneficial and harmful microorganisms on the skin, and accordingly prevent several skin conditions associated with microbial imbalance. Topical application of prebiotics, although insufficiently investigated, holds great promise in improving skin health. The purpose of this research was to determine the prebiotic potential of galacto-oligosaccharides (GOS) for skin microbiota and suitability for incorporation in different topical formulations, and finally, provide insights into their diffusion properties. - Methods : The prebiotic effect of GOS was evaluated through the influence on the growth of Staphylococcus epidermidis and Staphylococcus aureus, the most common resident and pathogenic bacterium of the skin microbiota, respectively. Also, with the future use of GOS in cosmetic products in mind, the diffusion of GOS molecules from two different topical formulations, hydrogel and oil-in-water (O/W) gel emulsion, was monitored employing Franz diffusion cell and two systems—with cellulose acetate membrane and transdermal diffusion test model, Strat-M® membrane. Course of fermentation and the amount of diffused GOS molecules were monitored using high-performance liquid chromatography (HPLC). - Results : The in vitro results revealed that GOS at a concentration of 5% (w/v) has a pronounced stimulatory effect on S. epidermidis, while simultaneously showing an inhibitory effect on S. aureus, both in nutrient broth and cosmetic formulations. GOS trisaccharide and tetrasaccharide diffusion coefficients from O/W gel emulsion were calculated to be 5.61·10−6 cm2 s−1 and 1.41·10−8 cm2 s−1, respectively. The diffusion coefficient of GOS trisaccharides from hydrogel was 3.22·10−6 cm2 s−1, while it was not determined for tetrasaccharides due to low diffused concentration. Transdermal diffusion tests revealed that GOS incorporated in two formulations stays at the surface of the skin even after 24 h. - Conclusion : When applied in adequate concentration, GOS has the potential to be used as a skin prebiotic. Novel GOS enriched formulations, Aristoflex® AVC-based hydrogel and Heliogelâ„¢-based O/W gel emulsion, provided efficient diffusion and delivery of prebiotic GOS molecules to the skin surface. Note de contenu : - MATERIALS AND METHODS : Materials - Bacterial strains and growth conditions - Preparation of cosmetic formulation - GOS prebiotic activity assay - Diffusion experiments - HPLC analysis - Calculation of the effective diffusion coefficients - Data processing and statistical analysis - RESULTS AND DISCUSSION : Study of the effect of GOS on the bacterial growth - Diffusion study of GOS from topical formulations - Table : Calculated effective diffusion coefficients of GOS from two different cosmetic formulations DOI : https://doi.org/10.1111/ics.12778 En ligne : https://drive.google.com/file/d/1GjfCRr_PxGlFjG2RqWlBkMdQX7msKHKi/view?usp=shari [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38133 [article]

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