| Titre : |
Three-dimensional-energy minimized models for calf skin type 1 collagen triple helix and microfibril : 1. The triple helical models |
| Type de document : |
texte imprimé |
| Auteurs : |
James M. Chen, Auteur ; Stephen H. Feairheller, Auteur ; Eleanor M. Brown, Auteur |
| Année de publication : |
1991 |
| Article en page(s) : |
p. 475-486 |
| Note générale : |
Bibliogr. |
| Langues : |
Américain (ame) |
| Index. décimale : |
675 Technologie du cuir et de la fourrure |
| Résumé : |
Molecular modeling methods were applied to the development of three dimensional structures of typ 1 collagen triple helices. The initial model was based on a triple helix of (Gly-Pro-Hyp). The amino acid sequences of the alpha 1 and 2 chains of calf skin Type 1 structure was nergy minimized to form all possible stabilizing interactions within the protein. Specific intraction sites which may contribute to the stability of the collagen molecule can be identified in the triple helical modls. The models may be used to target potential domains in collagen that contain sites for crosslinking reactions with chronium and other agents; determine what constraints on size, shape and molecular characteristics are likely to describe the optimum crosslinking agents; and suggest the application of which analytial and spectroscopic will give the most rigorous test of the computer models. |
| En ligne : |
https://drive.google.com/file/d/18kTOW6lP6Lr1yGyAdYw8jURC0V0eAo3P/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=8333 |
in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA) > Vol. LXXXVI, N° 12 (12/1991) . - p. 475-486
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Three-dimensional-energy minimized models for calf skin type 1 collagen triple helix and microfibril : 1. The triple helical models in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA), Vol. LXXXVI, N° 12 (12/1991)
