| Titre : |
Use of computer-generated models in studies of modified collagen |
| Type de document : |
texte imprimé |
| Auteurs : |
Eleanor M. Brown, Auteur ; Gregory King, Auteur |
| Année de publication : |
1996 |
| Article en page(s) : |
p. 161-170 |
| Note générale : |
Bibliogr. |
| Langues : |
Américain (ame) |
| Catégories : |
Collagène
Cuirs et peaux
Molécules -- Modèles
Simulation par ordinateur
|
| Index. décimale : |
675 Technologie du cuir et de la fourrure |
| Résumé : |
Production of leather from cattlehide is accomplished by the introduction of crosslinks between collagen triplehelices, microfibrils and fibrils. Present tanning technology uses chromium complexes to form crosslinks between acidic aminoacid side chains. Pretanning treatments that modify the primary amino groups of collagen have been reported to increase the efficiency of chrome tanning. To aide the effectiveness and efficiency of research leading to improved tanning technology, we have examined a fragment of our previously reported three dimensional model of the collagen microfibril.This 281 residue fragment of the microfibril model contains 15 lysine residues and 28 acidic residues distributed over the microfibril's 15 peptide chains. The effects of reductive alkylation and deamination of the lysine residues were simulated. Five independent binding sites in which carboxyl groups were located 7 to 11 Angström were indentified and a sphere of 8 Angström radius about the midpoint of each pair was isolated. The sites examined provide for the possibility of inter and intra microfibrillar stabilization. |
| En ligne : |
https://drive.google.com/file/d/1tAZW6ISSgdVgJkto4EN_sILi8ZHq3sG0/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=7794 |
in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA) > Vol. LXXXXI, N° 6 (06/1996) . - p. 161-170
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Use of computer-generated models in studies of modified collagen in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA), Vol. LXXXXI, N° 6 (06/1996)
