| Titre : |
Three-dimensional-energy minimized models for calf skin type 1 collagen triple helix and microfibril : 2. The "smith" microfibril |
| Type de document : |
texte imprimé |
| Auteurs : |
James M. Chen, Auteur ; Stephen H. Feairheller, Auteur ; Eleanor M. Brown, Auteur |
| Année de publication : |
1991 |
| Article en page(s) : |
p. 487-497 |
| Note générale : |
Bibliogr. |
| Langues : |
Américain (ame) |
| Index. décimale : |
675 Technologie du cuir et de la fourrure |
| Résumé : |
Molecular modeling methods were applied to the development of a three dimnsional structure for a Type 1 collagen microfibril model. The model was based on the energy minimized "smith" microfibril model containing the consesus plypeptide sequence (Gly-Pro-Hyp). The amido acid sequences of the alpha 1 and 2 chains of calf skin Type 1 collagen were substituted into the "collagen-like" (Gly-Pro-Hyp) "smith" microfibril model. The model was then energy minimized using molecular mechanics and evaluated structurally using graphics. Specific interaction sites which may contribute to the stability of collagen packing can be identified in this model. Computer graphics was used to display the Type 1 "smith" microfibril model to determine specific domains containing sites which would facilitate the evaluation of potential crosslinking agents. The Type 1 model can be used to suggest domains in collagen that contain on size, shape and molecular characteristics are likely to describe the optimum crosslinking agents; and the application of which analytical and spectroscopic techniques to real systems will give the most rigorous test of the computer models. |
| En ligne : |
https://drive.google.com/file/d/1fUzaWSfuzZE6aS7ddhruaqPVy2zZ2Ywy/view?usp=drive [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=8334 |
in JOURNAL OF THE AMERICAN LEATHER CHEMISTS ASSOCIATION (JALCA) > Vol. LXXXVI, N° 12 (12/1991) . - p. 487-497
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