[article]
| Titre : |
Elongated microparticles tuned for targeting hyaluronic acid delivery to specific skin strata |
| Type de document : |
document électronique |
| Année de publication : |
2021 |
| Article en page(s) : |
p. 738-747 |
| Note générale : |
Bibliogr. |
| Langues : |
Anglais (eng) |
| Catégories : |
Cosméceutique
Hyaluronique, acideL'acide hyaluronique est un type de polysaccharide (plus précisément une glycosaminoglycane) non fixé à une protéine centrale et largement réparti parmi les tissus conjonctifs, épithéliaux et nerveux animaux.
Il se trouve notamment dans l'humeur vitrée et le liquide synovial. Il est l'un des principaux composants de la matrice extracellulaire ainsi que de certaines mucoprotéines lorsqu'il est associé à une fraction protéique.
Depuis les années 1990, il est très utilisé dans divers dispositifs médicaux, médicamenteux et cosmétiques (présenté dans ce dernier cas comme "antistatique, humectant, hydratant, conditionneur cutané, anti-âge, etc."), bénéficiant d'un effet de mode grandement soutenu par une large publicité commerciale.
Contribuant de façon significative à la prolifération et à la migration des cellules, l'acide hyaluronique est aussi impliqué dans la progression de certains cancers. (Wikipedia)
Médicaments -- Administration par voie transcutanée
Micro-aiguilles
Particules (matières)
|
| Index. décimale : |
668.5 Parfums et cosmétiques |
| Résumé : |
- Objective : Microneedle or fractional laser applications are the most common topical delivery enhancement platforms. However, these methods of drug delivery are not skin strata specific. Drug delivery approaches which could target specific stratum of the skin remains a challenge. Elongated microparticles (EMPs) have been used in enhancing drug delivery into the skin. The aim of this study was to evaluate, for the first time, elongated silica microparticles with two different length profiles to enhance delivery of hyaluronic acid into different strata of human skin.
- Methods : Two types of EMPs—long (milled EMPs) or short (etched EMPs) length ranges were characterized. A prototypical liquid formulation (Fluorescent hyaluronic acid) with and without EMP enhancement were evaluated for hyaluronic acid delivery in ex-vivo human skin. High performance liquid chromatography, Typhoon fluorescence scanning system, laser scanning confocal microscopy and reflectance confocal microscopy (RCM) were used to validate F-HA stability, visualize fluorescein in the skin, image the depth of F-HA delivery in the skin and define EMP penetration in skin strata, respectively. Statistical analysis was conducted using GraphPad Prism 6 software (GraphPad Software Inc, USA).
- Results : Fluorescein-hyaluronic acid was stable and EMP enhanced skin penetration. RCM revealed that ‘etched EMP’ penetrated the skin to the stratum spinosum level. The vast majority (97.8%; p < 0.001) of the etched EMP did not penetrate completely through the viable epidermis and no obvious penetration into the dermis. In contrast, milled EMP showed 41-fold increase in penetration compared to the etched EMP but penetrated beyond the dermoepidermal junction.
- Conclusion : EMPs can enhance delivery of hyaluronic acid. Using EMPs with defined length distributions, which can be tuned for a specific stratum of the skin, can achieve targeted hyaluronic acid delivery. |
| Note de contenu : |
- MATERIALS AND METHODS : Materials - Methods - Statistical analysis
- RESULTS : Fluorescein-hyaluronic acid stability evaluation by HPLC - Microscopic characterization of milled and etched EMP morphologies - Evaluation of EMP-enhanced F-HA delivery in ex-vivo human skin - Depth of F-HA delivery in ex vivo human skin with and without EMP - Penetration and distribution of etched EMPs versus milled EMPs in different skin strata |
| DOI : |
https://doi.org/10.1111/ics.12749 |
| En ligne : |
https://drive.google.com/file/d/1rI_PBk-fp2RlBwfxGg4kX6PKSLPQns4r/view?usp=shari [...] |
| Format de la ressource électronique : |
Pdf |
| Permalink : |
https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=37054 |
in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° 6 (12/2021) . - p. 738-747
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