Enlarged rete pegs with excessive accumulation of melanosomes leading to darker aging spots revealed by histomorphological measurements of internal structures of the epidermis / Tatsuo Yamamura in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 3 (06/2023)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 45, N° 3 (06/2023) . - p. 387-399 Titre : Enlarged rete pegs with excessive accumulation of melanosomes leading to darker aging spots revealed by histomorphological measurements of internal structures of the epidermis Type de document : document électronique Auteurs : Tatsuo Yamamura, Auteur ; Soko Kobayashi, Auteur ; Ikuyo Yoshida, Auteur ; Ken-ichi Kuriyama, Auteur Année de publication : 2023 Article en page(s) : p. 387-399 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Cellules basales Chevilles de rete Les chevilles de rete (également appelées processus de rete ou crêtes de rete ) sont les extensions épithéliales qui se projettent dans le tissu conjonctif sous-jacent de la peau et des muqueuses. Épithélium cutané (violet) avec lamina propria (tissu conjonctif sous-jacent) (rose) - l'épithélium présente des chevilles rete. Les chevilles Rete protègent le tissu contre le cisaillement. Dans l'épithélium de la bouche, la gencive attachée présente des rete pegs, contrairement aux épithéliums sulculaire et jonctionnel. Le tissu cicatriciel manque de chevilles et les cicatrices ont tendance à se cisailler plus facilement que les tissus normaux. Aussi connues sous le nom de papilles, ce sont des épaississements vers le bas de l'épiderme entre les papilles dermiques. (Wikipedia) Dermatologie Mélanosome Microscopie confocale à balayage laser Peau -- Physiologie Taches pigmentaires (dermatologie) Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Various histological studies of facial pigmented spot sites such as solar lentigo have been reported, but few studies have used quantitative indices by histomorphometric analysis of the internal structure of pigmented spot sites using non-invasive methods. In the present study, to quantitatively elucidate morphological changes in the epidermis in male, darker-pigmented spots and female, light-pigmented spots, indices that characterize the internal structure of the epidermis in pigmented spot sites were measured using in vivo confocal laser scanning microscopy (CLSM). - Methods : The darkness of pigmented spots on the cheeks of 69 women and 43 men was analysed using image analysis software. The L* value was calculated from RGB values obtained from facial images. The internal structures of pigmented spots on the cheeks of 13 subjects were observed by CLSM. Various parameters were measured using CLSM images from the surface of the stratum corneum to the bottom of the dermal papillae, including the thickness of the epidermis, melanosome content, and shape of the dermal papillae. - Results : Mean ΔL* values between pigmented spots and non-pigmented areas of male subjects were significantly increased in the 40s and 50s compared with those of female subjects. Conspicuous pigmented spots increased in the 40s in male subjects and the 50s in female subjects. In CLSM observations, significant increases in the thickness of the epidermis and melanosome content were confirmed in pigmented spots compared with surrounding non-pigmented areas. In particular, melanosome content in the male subject group with dark-coloured pigmented spots increased significantly to about eight times that of non-pigmented areas, and more than double that of the male subject group with light-coloured pigmented spots. - Conclusion : From the measurements of quantitative parameters, morphological changes in the epidermis were clearly related to the surface colour tone of pigmented spots. Darker pigmented spot sites tended to show longer rete pegs in the epidermis. Accumulation of melanosomes in epidermal basal cells could be considered to increase with the degree of elongation of rete pegs at pigmented spot sites and, thus, induce darker pigmented spots. Note de contenu : - Darkness of pigmented spots - Classification of pigmented spots by facial images - In vivo confocal laser scanning microscopy imagin - Image analysis - Plasmin-like activity measurement - Table 1 : Skin internal structure parameters of pigmented spot sites DOI : https://doi.org/10.1111/ics.12846 En ligne : https://drive.google.com/file/d/1N7kURDEzzTsv7rwPy1lezdamlIsgqbi6/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=39569 [article]

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Melanosome transportation control via innovative active / Kiyotaka Tanaka in PERSONAL CARE EUROPE, Vol. 8, N° 6 (11/2015)  

[article]  inPERSONAL CARE EUROPE > Vol. 8, N° 6 (11/2015) . - p. 41-44 Titre : Melanosome transportation control via innovative active Type de document : texte imprimé Auteurs : Kiyotaka Tanaka, Auteur ; Arunasiri Iddamalgoda, Auteur Année de publication : 2015 Article en page(s) : p. 41-44 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Agents de blanchiment Biomolécules actives Kinésine Mélanosome Index. décimale : 668.5 Parfums et cosmétiques Résumé : Various biological parts and structures are formed within cells and transported to parts of the body by driving proteins called motor proteins. For example, melanin pigment that influences skin tone is produced in melanocytes and passed to keratinocytes through dendrites. Keratinocytes absorb melanin from surrrounding areas (or tips of dendrites including melanin) and darken. Usually, melanin generated in melanocytes is transported to the end of dendrites. In this process, melanosomes are transported by kinesin, a type of motor protein. Melanin is transported along dendrites while it is synthesised in sacks called melanosomes. Kinesin is involved in the transport of melanosomes to the end of dendrites (Fig. 1). Kinesin is a protein with limb-like strutures. Kinesin holds up melanosome using hand-like strutures (light chains) and walks on microtubules using leg-like structures (heavy chains). Kinesins travel in a specific direction, always toward the end of dendrites, namely keratinocytes. They move leg-like structures alternately as though they are walking; Since they look like micro robots, they are also know as 'biological nanomachines'. Note de contenu : - Kinesin as a new target of skin lightening - Development of a plant based kinesin inhibitor - Inhibition of melanin transportation - Skin lightening effect on 3D skin model - Clinical study on human skin - Identifying active molecule - Relationship between skin lightening and 'Cinderella time' - New skin lightening theory En ligne : https://drive.google.com/file/d/1PfSLWr4J3wXvuzO_h1qWuqxOgrx7Ohl4/view?usp=drive [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=24936 [article]

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UV-melanogenesis and cosmetic whitening / Masamitsu Ichihashi in IFSCC MAGAZINE, Vol. 6, N° 4 (10-11-12/2003)

[article]  inIFSCC MAGAZINE > Vol. 6, N° 4 (10-11-12/2003) . - p. 279-286 Titre : UV-melanogenesis and cosmetic whitening Type de document : texte imprimé Auteurs : Masamitsu Ichihashi, Auteur ; Yoko Funasaka, Auteur ; Masahiro Oka, Auteur ; Keishi Araki, Auteur ; Hideya Ando, Auteur Année de publication : 2003 Article en page(s) : p. 279-286 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Agents de blanchiment Mélanocytes Mélanogénèse Mélanosome Peau Rayonnement ultraviolet Index. décimale : 668.5 Parfums et cosmétiques Résumé : Pigmented spots that develop in sun-exposed skin, particularly on the face and the dorsa of the hands, are one of the major problems to be treated or prevented by common and functional cosmetics for Asian women having moderate constitutive pigmentation. Recent scientific advances in the understanding of the mechanisms of hyper- and hypo-melanogenesis in animal and human skin have been contributing to the development of novel topical whitening agents as cosmetics. The same applies for the systemic use of drugs and supplements that are expected to regulate melanin synthesis via up-and down-regulation of mRNA of enzymes and oter factors involved, and/or modulating the function of enzymes pivotal in melanogenesis. In this review, we describe the mechanisms of melanogenesis in relevance to melanosomes, and their transportation and transfer from melanocytes to keratinocytes based on the recent evidence. Further, a role of alphamelanocyte stimulating hormone (α-MSH) and reactive oxygen species (ROS) in UV-melanogenesis is explained focusing on intracellular signal transduction. Finally, future strategy to develop lightening agents for the pigmented skin is discussed, in addition to the introduction of whitening agents previously developed in Japan. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10545 [article]

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