Assessment of penetration and permeation of caffeine by confocal Raman spectroscopy in vivo and ex vivo by tape stripping / Ghaith Kourbaj in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 1 (02/2023)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 45, N° 1 (02/2023) . - p. 14-28 Titre : Assessment of penetration and permeation of caffeine by confocal Raman spectroscopy in vivo and ex vivo by tape stripping Type de document : document électronique Auteurs : Ghaith Kourbaj, Auteur ; Annette Gaiser, Auteur ; Stephan Bielfeldt, Auteur ; Dominique Lunter, Auteur Année de publication : 2023 Article en page(s) : p. 14-28 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Caféine Décapage Pénétration cutanée Perméation Rubans adhésifs Spectroscopie Raman Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : Tape stripping is an often-used non-invasive destructive method to investigate the skin penetration of a substance. In recent years, however, the suitability of confocal Raman spectroscopy (CRS) as a non-invasive method of non-destructive examination of the skin has become increasingly apparent. In this study, we compared invasion and depletion penetration and permeation kinetics of a 2% caffeine solution with and without 1,2-pentanediol as a penetration enhancer measured with CRS and tape stripping. - Methods : Porcine skin was used for tape stripping and human skin for CRS. 2% caffeine solution was applied to the skin for different incubation times. Human skin was then examined by CRS while caffeine was extracted from porcine skin and quantified via reverse-phase HPLC. Fluxes were also measured and calculated by sum of the total amounts of caffeine penetrated into the skin. - Results : Without penetration enhancers, there is hardly any difference between the penetration profiles of the two measurement methods for invasion, but the curves for depletion are different. Furthermore, the calculated flux values for the invasion are almost identical, but for the depletion the tape stripping values are about twice as high as the CRS values. - Conclusion : The relevance of conducting invasion and depletion studies became clear and was able to show the still existing problems in the comparability of CRS and tape stripping. Note de contenu : - MATERIALS AND METHODS : Materials - Test solutions - Ex vivo tape stripping - In vivo confocal Raman spectroscopy - Statistics - RESULTS : Results of ex vivo tape stripping - Results of in vivo CRS measurements - DISCUSSION : Tape stripping results - DISCUSSION OF THE CRS RESULTS : Comparing tape stripping results to CRS results - Table 1 : Make-up of test solutions - Table 2 : Incubation times - Table 3 : Flux from different experimental setups - Table 4 : Flux from different experimental setups. Flux over 1 h from different experimental setups DOI : https://doi.org/10.1111/ics.12820 En ligne : https://drive.google.com/file/d/144nCOFKEh8YNpyXDssgQ2dBq7xZHp7Ff/view?usp=share [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=38816 [article]

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Caffeine improves barrier function in male skin / J. M. Brandner in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 28, N° 5 (10/2006)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 28, N° 5 (10/2006) . - p. 343-347 Titre : Caffeine improves barrier function in male skin Type de document : texte imprimé Auteurs : J. M. Brandner, Auteur ; M. J. Behne, Auteur ; B. Huesing, Auteur ; I. Moll, Auteur Année de publication : 2006 Article en page(s) : p. 343-347 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Caféine Peau masculine Perte insensible en eau Testostérone Index. décimale : 668.5 Parfums et cosmétiques Résumé : L'influence des androgènes, en particulier de la testostérone et de son effecteur la dihydro-testostérone, constitue un inconvénient pour la peau des hommes, comme la réduction de la viabilité des cheveux et la réduction de la capacité de réparation de la perméabilité de la barrière épidermique. La dihydro-testostérone peut agir, entre autre, comme un inhibiteur d'adenyl cyclase. D'un autre côté, la caféine est une substance peu chère et sans danger (aux concentrations normales) utilisée dans de nombreux produits cosmétiques. Elle peut agir comme inhibiteur de la phosphodiestérase. Pour prouver l'hypothèse que la caféine, en tant qu'inhibiteur de phosphodiestéarase est capable de réduire les effets induits par la testostérone sur la fonction barrière, nous avons réalisé une étude en double aveugle (avec placebo) sur des volontaires en bonne santé. Dans cette étude, on applique pendant sept jours une préparation constituée d'un gel d'HEC contenant 0,5% de caféine sur l'un des avant-bras d'hommes et de femmes volontaires et un gel d'HEC sans caféine sur l'autre avant-bras, et on mesure la perte trans-épidermique d'eau avant et à la fin de la période de traitement La TEWL basique n'est pas différente entre les hommes et les femmes, mais l'application de caféine réduit significativement la TEWL de la peau des hommes par rapport à celles des femmes. Nous concluons que la caféine est bénéfique à la fonction barrière de la peau des hommes. DOI : 10.1111/j.1467-2494.2006.00346.x En ligne : https://onlinelibrary.wiley.com/doi/10.1111/j.1467-2494.2006.00346.x Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=26424 [article]

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Caffeine microspheres an attractive carrier for optimum skin penetration / Sandrine Bourgeois in IFSCC MAGAZINE, Vol. 12, N° 4 (10-11-12/2009)

[article]  inIFSCC MAGAZINE > Vol. 12, N° 4 (10-11-12/2009) . - p. 359-363 Titre : Caffeine microspheres an attractive carrier for optimum skin penetration Type de document : texte imprimé Auteurs : Sandrine Bourgeois, Auteur ; Marie-Alexandrine Bolzinger, Auteur ; Jocelyne Pelletier, Auteur ; Jean-Pierre Valour, Auteur ; Stéphanie Briançon, Auteur Année de publication : 2010 Article en page(s) : p. 359-363 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Absorption cutanée Caféine Cosmétiques Microsphères Index. décimale : 668.5 Parfums et cosmétiques Résumé : Caffeine is an effective slimming agent used for topical administration or in cosmetic products. The formulation must be such that caffeine reaches the adipocytes in the hypodermis. Biodegradable caffeine-loaded microspheres were evaluated for the transport of caffeine to its site of action for 24 h and upto 72 h. The mean diameter of the microspheres was 2.8 μm and their caffeine loading was 2.3 mg g-1 of particles. The permeation of caffeine from microspheres applied in aqueous suspension or from solution was evaluated through in vitro diffusion measurements with static Franz cells (n = 6) over 24 h or 72 h. The first experiments carried out on full-thickness skin without hypodermis showed that after 24 h the total amount of caffeine was twice as high from microspheres as from aqueous solution (22.6% vs. 9.99%). The results suggested that microspheres could easily penetrate through the skin and accumulate in the receptor compartment, ensuring continuous caffeine release. When the hypodermis was retained, microsphere penetration was only slightly decreased. After 72 hours of exposure the receptor fluid contained 15.3% free caffeine and 27.8% encapsulated fraction. The hypodermis hindered solution permeation, and therefore the free caffeine content was lower. Permeation of microspheres was not stopped by the presence of hypodermis. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10139 [article]

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Deformable liposomes as enhancer of caffeine penetration through human skin in a Franz diffusion cell test / E. Abd J. Gomes in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 43, N° 1 (02/2021)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 43, N° 1 (02/2021) . - p. 1-10 Titre : Deformable liposomes as enhancer of caffeine penetration through human skin in a Franz diffusion cell test Type de document : document électronique Auteurs : E. Abd J. Gomes, Auteur ; C. C. Sales, Auteur ; S. Yousef, Auteur ; F. Forouz, Auteur ; K. C. Telaprolu, Auteur ; M. S. Roberts, Auteur ; J. E. Grice, Auteur ; P. S. Lopes, Auteur ; V. R. Leite-Silva, Auteur ; N. Andréo‐Filho, Auteur Année de publication : 2021 Article en page(s) : p. 1-10 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Barrière cutanée Caféine Essais (technologie) Formulation (Génie chimique) Liposomes Pénétration (physique) Perméation Polypropylène glycol Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : The permeation of hydrophilic molecules through the skin is still a challenge due to the barrier posed by stratum corneum, the outermost layer of the skin. Liposomes have frequently been used as carriers for different types of drugs and may also function as permeation enhancers. Propylene glycol has also been used as an edge activator in liposomes to increase the permeation. The aim of this work was to prepare liposomes containing an edge activator and loaded with caffeine to evaluate the potential of caffeine reaching the deeper layers in the skin. - Methods : The formulations were prepared by a top-down process using high-pressure homogenization at 200 00 psi for 10 min. They were characterized by size, polydispersity index (PI), zeta potential (ZP), pH, caffeine content and encapsulation efficiency (EE%) on preparation (time zero) and after 30 days. Cytotoxicity of blank and loaded liposomes was assessed by MTT proliferation assay with a normal keratinocyte cell line (HaCaT). In vitro permeation tests were performed with human skin in Franz cells over 24 h, and caffeine concentration was determined in the skin surface, stratum corneum, dermo-epidermal fraction and receptor medium by HPLC. - Results : The caffeine liposomes with (DL-Caf) or without propylene glycol (CL-Caf) showed, respectively, mean size 94.5 and 95.4 nm, PI 0.48 and 0.42, ZP + 1.3 and + 18.1 mV and caffeine content of 78.57 and 80.13%. IC50 values of caffeine in DL-Caf (3.59 v/v %) and CL-Caf (3.65 v/v %) were not significantly different from conventional blank liposome (3.27 v/v %). The DL-Caf formulation presented the best capability to enhance the caffeine permeation through the skin, resulting 1.94-folds higher than caffeine solution. Furthermore, the caffeine flux from DL-Caf was 1.56- and 3.05-folds higher than caffeine solution and CL-Caf, respectively. On the other hand, CL-Caf showed the lowest caffeine penetration revealing the importance of edge activator to aid hydrophilic drug penetration to all skin layers. - Conclusion : The DL-Caf formulation tested was able to improve the permeation of caffeine through the stratum corneum and dermo-epidermal layers, suggesting that this delivery system may be effective for deep skin delivery of hydrophilic drugs. Note de contenu : - MATERIALS AND METHODS : Materials - Preparation of liposomes - Characterization of liposome formulations - Caffeine quantification and encapsulation efficiency (EE%) - Cell culture studies - Treatment solutions - Cytotoxicity assay : MTT test - Caffeine skin permeation studies - Sample analysis - Data analysis and statistics - RESULTS AND DISCUSSION : Characterization of liposomes - Encapsulation Efficiency (EE%) - Cytotoxicity tests - Permeation of Caffeine from Liposomes and Controls - Table 1 : Liposome formulations and controls composition - Table 2 : Characterization of liposomes formulations data. Measurements were done at zero and thirtieth days. All data are results of three analyses (n = 3) - Table 3 : Content of caffeine in liposomes formulation and encapsulation efficiency (EE%) - Table 4 : IC50 values of conventional liposome and caffeine encapsulated on HaCaT cell line - Table 5 : Permeation parameters following 24-h application of caffeine from liposome formulations and controls to full-thickness human skin (mean SD, n = 3) DOI : https://doi.org/10.1111/ics.12659 En ligne : https://drive.google.com/file/d/1xwcDoaHKMJNtr-XBVeV4cz__-o2pSCsZ/view?usp=share [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=35438 [article]

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Development of SEDDS formulation containing caffeine for dermal delivery / Igor de Andrade Assunção de Almeida in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 2 (03-04/2023)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 45, N° 2 (03-04/2023) . - p. 255-265 Titre : Development of SEDDS formulation containing caffeine for dermal delivery Type de document : document électronique Auteurs : Igor de Andrade Assunção de Almeida, Auteur ; Thiago da Silva Honório, Auteur ; Flavia Almada do Carmo, Auteur ; Zaida Maria Faria de Freitas, Auteur ; Lucio Mendes Cabral, Auteur ; Letícia Coli Louvisse de Abreu, Auteur Année de publication : 2023 Article en page(s) : p. 255-265 Note générale : Bibliogr. Langues : Anglais (eng) Catégories : Amincissants Caféine Caractérisation Cellules -- Cultures et milieux de culture Cellulite Dermo-cosmétologie Emulsions -- Emploi en cosmétologie Essais (technologie) Formulation (Génie chimique) Médicaments -- Administration par voie cutanée Nanoémulsions Peau -- Soins et hygiène Perméation Potentiel zeta Solubilité Taille des gouttelettes Index. décimale : 668.5 Parfums et cosmétiques Résumé : - Objective : The objective of this work was to develop a self-emulsifying drug delivery system (SEDDS) containing caffeine for the treatment of cellulite. - Methods : SEDDS were prepared using the solution method. 0.5% (w/v) caffeine was added to the previously selected excipients. The system was characterized by droplet size, zeta potential, emulsification time and long-term stability. In vitro release and skin permeation were investigated using Franz-type diffusion cells. The cytotoxicity was evaluated on normal human keratinocytes. - Results : Caffeine SEDDS were thermodynamically stable, with a zeta potential less than - 22 mV and droplet size around 30 nm, and were long-term stable. The permeation study showed that the formulation promoted caffeine accumulation in the skin layers, suggesting an increase in local circulation. Cytotoxicity studies on HaCaT cells were not conclusive as the surfactant used indicated false-positive results due to its high molar mass. - Conclusion : It was possible to obtain a stable SEDDS that could cause an increase in blood flow in the applied area, resulting in cellulite reduction. Note de contenu : - MATERIALS AND METHODS : Preparations of self-emulsifying drug delivery systems - Characterization of self-emulsifying drug delivery systems - Measurement of droplet size, polydispersity index and zeta potential - Cytotoxicity evaluation in HaCaT cells - Statistical analysis - RESULTS AND DISCUSSION : Preparation of SEDDS caffeine formulations - Characterization of SEDDS - Evaluation of the permeation profile - Formulation safety - Table 1 : SEDDS formulations - Table 2 : Nanoemulsion classification system - Table 3 : Solubility tests - Table 4 : Droplet size results - Table 5 : Initial zeta potential and after 6 months - Table 6 : Stability study T0 and T6 months DOI : https://doi.org/10.1111/ics.12841 En ligne : https://drive.google.com/file/d/1-ASq7IknoSSPuChlSeOqGI4aCCpdvrOi/view?usp=share [...] Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=39175 [article]

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Efficiency of emulsifier-free emulsions in delivering caffeine and a-tocopherol to human skin / Hichem Kichou in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 45, N° 3 (06/2023)  

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Evaluation of the efficacy of a topical cosmetic slimming product combining tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol, In vitro, ex vivo and in vivo studies / R. Roure in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 33, N° 6 (12/2011)  

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Preparation and evaluation of caffeine bioadhesive emulgels for cosmetic applications based on formulation design using QbD tools / Y. de Lafuente in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 42, N° 6 (12/2020)  

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Synergistic effects of taurine and caffeine on regulation of the hair cycle : composition of bioactives against premature hair loss / Thomas Welss in IFSCC MAGAZINE, Vol. 15, N° 2 (04-05-06/2012)

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Transepidermal UV radiation of scalp skin ex vivo induces hair follicle damage that is alleviated by the topical treatment with caffeine / Jennifer Gherardini in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 41, N° 2 (04/2019)  

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Use of caffeine-containing MIL-100 (Fe) metal organic framework as a high-performance smart anticorrosion coating to protect stainless steel in 3.5 wt% NaCl solution / Zahra Akhavan-Bahabadi in JOURNAL OF COATINGS TECHNOLOGY AND RESEARCH, Vol. 20, N° 3 (05/2023)  

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