In vitro human nail penetration and kinetics of panthenol / X. Hui in INTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Vol. 29, N° 4 (08/2007)  

[article]  inINTERNATIONAL JOURNAL OF COSMETIC SCIENCE > Vol. 29, N° 4 (08/2007) . - p. 277-282 Titre : In vitro human nail penetration and kinetics of panthenol Type de document : texte imprimé Auteurs : X. Hui, Auteur ; Howard I. Maibach, Auteur ; Y. Appa, Auteur ; S. Barbadillo, Auteur ; R. C. Wester, Auteur ; S. B. Hornby, Auteur Année de publication : 2007 Article en page(s) : p. 277-282 Note générale : Bibliogr. Langues : Anglais (eng) Tags : Human  nail  In  vitro  transungual  delivery  Kinetics  Non-lacquer  film  formulation  Penthanol Index. décimale : 668.5 Parfums et cosmétiques Résumé : The in vitro absorption of panthenol into and through the human nail was examined in this study. Panthenol, the alcohol form of pantothenic acid (vitamin B5), is believed to act as a humectant and improve the flexibility and strength of nails. A liquid nail treatment formulated with panthenol (2%) was compared to a solution of panthenol (2%) in water. Fingernail specimens were dosed daily for 7 days with either the nail treatment (non-lacquer film forming) formulation or aqueous solution with sampling performed every 24 h. Panthenol concentrations were determined in the dorsal surface, interior (by drilling and removal) and in the supporting bed under the human nail. Panthenol levels in the dorsal nail (R2 = 0.87 ; P < 0.001), nail interior (R2 = 0.94 ; P < 0.001) and nail supporting bed (R2 = 0.79 ; P < 0.003) showed a significant linear increase with each day of dosing. Significantly more panthenol was delivered into the interior nail and supporting bed by a nail treatment formulation than from an aqueous solution. The film acts not only as a reservoir of panthenol, but also acts to increase the hydration of the nail and the thermodynamic activity of panthenol as well, thereby enhancing diffusion. DOI : 10.1111/j.1467-2494.2007.00373.x En ligne : http://onlinelibrary.wiley.com/doi/10.1111/j.1467-2494.2007.00373.x Format de la ressource électronique : Pdf Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=4604 [article]

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New Technique to Capture Viscoelastic Changes in Hair Induced by Mechanical Stress / S. B. Hornby in IFSCC MAGAZINE, Vol. 5, N° 2 (04-05-06/2002)

[article]  inIFSCC MAGAZINE > Vol. 5, N° 2 (04-05-06/2002) . - p. 93-97 Titre : New Technique to Capture Viscoelastic Changes in Hair Induced by Mechanical Stress Type de document : texte imprimé Auteurs : S. B. Hornby, Auteur ; Nigel J. P Winsey, Auteur ; Stephen P. Bucknell, Auteur Année de publication : 2002 Article en page(s) : p. 93-97 Note générale : Bibliogr. Langues : Anglais (eng) Tags : 'Cyclic  testing'  Fatigue  'Elastic  modulus'  Resiliency  'Tensile  stress'  'Hair  breakage' Index. décimale : 668.5 Parfums et cosmétiques Résumé : In a previous article [1], we have described the mechanical fatigue behaviour of hair fibers subjected to intermitted tensile deformations using the Cyclic Tester (Dia-Stron, Ltd., Andover, UK) in order to mimic stresses encountered during grooming procedures. The instrument imparts repeated tensile load cycles to the hair and records the numbers of cycles at the break point of each hair fiber. The distributions of the number of cycles required to cause hair fiber breakage were analyzed using the Weibull distribution and the beneficial effect of certain conditioners was discussed. The Cyclic Tester is also capable of recording load-elongation data for the hair fiber during the load cycles. In this study, we captured the load elongation data at selected load cycles of very damaged tip ends of single hair fibers and compared this data to that obtained for the undamaged root end of the same fiber using the Cyclic Tester. The changes in the hair fiber elastic and viscoelastic characteristics of very damaged and unaltered hair as a function of a number of prior deformations were compared. The instrument was enable to give a portrait of the viscoelastic changes in hair during repetitive stress. Permalink : https://e-campus.itech.fr/pmb/opac_css/index.php?lvl=notice_display&id=10651 [article]

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